Search Results - "de Souza, Patricia Coutinho"

OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth by Towner, Rheal A., Smith, Nataliya, Saunders, Debra, Brown, Chase A., Cai, Xue, Ziegler, Jadith, Mallory, Samantha, Dozmorov, Mikhail G., Coutinho De Souza, Patricia, Wiley, Graham, Kim, Kyeongsoon, Kang, Shinwook, Kong, Doo-Sik, Kim, Young-Tae, Fung, Kar-Ming, Wren, Jonathan D., Battiste, James

“…Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug…”
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Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts by Coutinho de Souza, Patricia, Mallory, Samantha, Smith, Nataliya, Saunders, Debra, Li, Xiao-Nan, McNall-Knapp, Rene Y, Fung, Kar-Ming, Towner, Rheal A

“…Pediatric glioblastomas (pGBM), although rare, are one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to…”
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928 A translational approach to catalog pancreatic cancer heterogeneity using spatial genomics in large patient cohorts for target validation and rational combination selection by Jabado, Omar, Fan, Li, Souza, Patricia Coutinho de, Harris, Angelo, Chaparro, Arturo, Qutaish, Mohammed, Si, Han, Dannenberg, Jan-Hermen, Sasser, Kate, Couto, Suzana, Fereshteh, Mark

“…BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with short overall survival; the standard of care (SoC) is chemotherapy…”
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238 Molecular dissection of tumor-immune microenvironment factors associated with response to checkpoint inhibitor therapy in non-small cell lung cancer patients using nanostring digital spatial profiling by Jabado, Omar, Couto, Suzana, Blum, Jordan, Franken, Patrick, Souza, Patricia Coutinho de, Jure-Kunkel, Maria, Pencheva, Nora, Higgs, Brandon, Sasser, Kate, Fereshteh, Mark

“…BackgroundUnderstanding the dynamics of immune cells in the lung tumor microenvironment following immune checkpoint inhibitor (ICI) therapy is important for…”
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Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH‐A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR by Varma, Gopal, Seth, Pankaj, Coutinho de Souza, Patricia, Callahan, Cody, Pinto, Jocelin, Vaidya, Manushka, Sonzogni, Olmo, Sukhatme, Vikas, Wulf, Gerburg M., Grant, Aaron K.

“…In many tumors, cancer cells take up large quantities of glucose and metabolize it into lactate, even in the presence of sufficient oxygen to support oxidative…”
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In vivo detection of distal tumor glycolytic flux stimulated by hepatic ablation in a breast cancer model using hyperpolarized 13C MRI by Goodwin, J. Scott, Tsai, Leo L., Mwin, David, Coutinho de Souza, Patricia, Dialani, Svayam, Moon, John T., Zhang, Zheng, Grant, Aaron K., Ahmed, Muneeb

“…Hepatic thermal ablation therapy can result in c-Met-mediated off-target stimulation of distal tumor growth. The purpose of this study was to determine if a…”
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PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation by Dou, Qianhui, Grant, Aaron K., Callahan, Cody, Coutinho de Souza, Patricia, Mwin, David, Booth, Adam L., Nasser, Imad, Moussa, Marwan, Ahmed, Muneeb, Tsai, Leo L.

“…Metabolic reprogramming, in particular, glycolytic regulation, supports abnormal survival and growth of hepatocellular carcinoma (HCC) and could serve as a…”
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ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models by Ziegler, Jadith, Pody, Richard, Coutinho de Souza, Patricia, Evans, Blake, Saunders, Debra, Smith, Nataliya, Mallory, Samantha, Njoku, Charity, Dong, Yunzhou, Chen, Hong, Dong, Jiali, Lerner, Megan, Mian, Osamah, Tummala, Sai, Battiste, James, Fung, Kar-Ming, Wren, Jonathan D, Towner, Rheal A

“…Despite current therapies, glioblastoma is a devastating cancer, and validation of effective biomarkers for it will enable better diagnosis and therapeutic…”
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OKN-007 decreases free radical levels in a preclinical F98 rat glioma model by Coutinho de Souza, Patricia, Smith, Nataliya, Atolagbe, Oluwatomisin, Ziegler, Jadith, Njoku, Charity, Lerner, Megan, Ehrenshaft, Marilyn, Mason, Ronald P., Meek, Bill, Plafker, Scott M., Saunders, Debra, Mamedova, Nadezda, Towner, Rheal A.

“…Free radicals are associated with glioma tumors. Here, we report on the ability of an anticancer nitrone compound, OKN-007 [Oklahoma Nitrone 007; a disulfonyl…”
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OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model by de Souza, Patricia Coutinho, Balasubramanian, Krithika, Njoku, Charity, Smith, Natalyia, Gillespie, David L., Schwager, Andrea, Abdullah, Osama, Ritchey, Jerry W., Fung, Kar-Ming, Saunders, Debra, Jensen, Randy L., Towner, Rheal A.

“…Background Glioblastoma is a malignant World Health Organization (WHO) grade IV glioma with a poor prognosis in humans. New therapeutics are desperately…”
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Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas by Towner, Rheal A., Smith, Nataliya, Saunders, Debra, De Souza, Patricia Coutinho, Henry, Leah, Lupu, Florea, Silasi-Mansat, Robert, Ehrenshaft, Marilyn, Mason, Ronald P., Gomez-Mejiba, Sandra E., Ramirez, Dario C.

“…Free radicals play a major role in gliomas. By combining immuno-spin-trapping (IST) and molecular magnetic resonance imaging (mMRI), in vivo levels of free…”
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Abstract 3585: Probing the relationship between renal carcinoma perfusion, hypoxia, and metabolism during response to VEGFR inhibition and at resistance by Dou, Qianhui, de Souza, Patricia Coutinho, Wang, Xiaoen, Grant, Aaron K., Tsai, Leo L.

“…Clear cell renal cell carcinoma (ccRCC) is the most common primary kidney cancer. VEGF-receptor tyrosine kinase inhibitors remain a second-line or concurrent…”
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PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma ProliferationSummary by Qianhui Dou, Aaron K. Grant, Cody Callahan, Patricia Coutinho de Souza, David Mwin, Adam L. Booth, Imad Nasser, Marwan Moussa, Muneeb Ahmed, Leo L. Tsai

“…Background & Aims: Metabolic reprogramming, in particular, glycolytic regulation, supports abnormal survival and growth of hepatocellular carcinoma (HCC) and…”
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Systemic high-level IDUA enzyme activity with correction of neurologic deficit in mucopolysaccharidosis type I mice by ex vivolentiviral transduction of hematopoietic stem cells by Belur, Lalitha, McKenzie, Jessica, Podetz-Pedersen, Kelly, Karlen, Andrea, de Souza, Patricia Coutinho, LaBarre, Shelby, Smith, Miles, Huber, Avery, Detellis, Jennifer, Gagnidze, Khatuna, Parsons, Geoff, Tsai, Hsing-Chen, McIvor, R. Scott, Bonner, Melissa

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Systemic high-level IDUA enzyme activity with correction of neurologic deficit in mucopolysaccharidosis type I mice by lentiviral transduction of hematopoietic stem cells by Belur, Lalitha, McKenzie, Jessica, Podetz-Pedersen, Kelly, Karlen, Andrea, de Souza, Patricia Coutinho, LaBarre, Shelby, Smith, Miles, Huber, Avery, Detellis, Jennifer, Gagnidze, Khatuna, Parsons, Geoff, Tsai, Hsing-Chen, McIvor, R. Scott, Bonner, Melissa

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Nanoformulations for therapy of pancreatic and liver cancers by de Souza, Patricia Coutinho, Ranjan, Ashish, Towner, Rheal A

“…Pancreatic and liver cancers often have poor prognoses. Clinically, pancreatic and liver cancer requires early diagnosis, and surgery is often associated with…”
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Abstract 205: ELTD1 and Plexin-B2 as novel antibody therapies against glioma biomarkers by Ziegler, Jadith, Pody, Richard, Rodriguez, Landon, Smith, Nataliya, Saunders, Debra, Coutinho de Souza, Patricia, Wren, Jonathan, Towner, Rheal

“…PURPOSE: Gliomas consist of up to 80% of malignant brain tumors that are invasive and typically resistant to radiotherapy and chemotherapy. Finding biomarkers…”
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Abstract 2034: Spatial transcriptomics identifies unique pharmacodynamic effects of checkpoint inhibitor treatment on the tumor microenvironment in NSCLC by Fan, Li, Jabado, Omar, Pencheva, Nora, Coutinho de Souza, Patricia, Higgs, Brandon, Harris, Angelo, Franken, Patrick, Muthuswamy, Anantharaman, Jure-Kunkel, Maria, Couto, Suzana, Sasser, Kate, Fereshteh, Mark

“…Background: Immune checkpoint inhibitor (ICI) therapy has improved outcomes in non-small cell lung cancer (NSCLC), particularly in patients with high tumor…”
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Abstract 3267: Eltd1 as an anti-angiogenic therapy against glioma tumors by Ziegler, Jadith, Smith, Nataliya, Saunders, Debra, Evans, Blake, Battiste, James D., Sughrue, Michael, Tompkins, Paul, Sutton, Jake, Lerner, Megan, Coutinho de Souza, Patricia, Fung, Kar-Ming, Wren, Jonathan, Towner, Rheal

“…Gliomas consist of up to 80% of malignant brain tumors that are invasive and typically resistant to radiotherapy and chemotherapy. Finding biomarkers to…”
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In vivo detection of distal tumor glycolytic flux stimulated by hepatic ablation in a breast cancer model using hyperpolarized 13 C MRI by Goodwin, J Scott, Tsai, Leo L, Mwin, David, Coutinho de Souza, Patricia, Dialani, Svayam, Moon, John T, Zhang, Zheng, Grant, Aaron K, Ahmed, Muneeb

“…Hepatic thermal ablation therapy can result in c-Met-mediated off-target stimulation of distal tumor growth. The purpose of this study was to determine if a…”
Get full text