Profile and Outcomes of Hospitalized COVID-19 Patients during the Prevalence of the Omicron Variant According to the Brazilian Regions: A Retrospective Cohort Study from 2022

Profile and Outcomes of Hospitalized COVID-19 Patients during the Prevalence of the Omicron Variant According to the Brazilian Regions: A Retrospective Cohort Study from 2022

We investigated the clinical-epidemiological profile and outcomes of COVID-19 patients hospitalized in 2022, during the Omicron variant/subvariant prevalence, in different Brazilian regions to identify the most vulnerable subgroups requiring special attention. Data from COVID-19 patients were extrac...

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Bibliographic Details
Published in:Vaccines (Basel) Vol. 11; no. 10; p. 1568
Main Authors: Drummond, Pedro Dutra, de Salles, Daniel Bortot, de Souza, Natália Satchiko Hojo, Oliveira, Daniela Carine Ramires, Guidoni, Daniel Ludovico, de Souza, Fernanda Sumika Hojo
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-10-2023
MDPI
Subjects:
Age
Age groups
Brazil
Care and treatment
Cohort analysis
Comorbidity
Confidence intervals
COVID-19
COVID-19 vaccines
Disease prevention
Drug dosages
Epidemiology
Hospital patients
Hospitalization
Hospitals
Infections
Intensive care
Missing data
Mortality
Older people
outcomes
Pandemics
Patient outcomes
Patients
Population
Public health
Regions
Severe acute respiratory syndrome coronavirus 2
Subgroups
Vaccination
variants of concern
Ventilators
Brazil
China
COVID-19 vaccines
Brazil
outcomes
variants of concern
vaccination
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Summary:We investigated the clinical-epidemiological profile and outcomes of COVID-19 patients hospitalized in 2022, during the Omicron variant/subvariant prevalence, in different Brazilian regions to identify the most vulnerable subgroups requiring special attention. Data from COVID-19 patients were extracted from the national Information System for Epidemiological Surveillance of Influenza (SIVEP-Gripe database), and analyses stratified by region and age group were conducted. The constructed dataset encompassed clinical-epidemiological information, intensive care unit admission, invasive and non-invasive ventilation requirements, vaccination status, and evolution (cure or death). It was observed that there were significant differences in the vaccination rates between regions, in the occurrence of unfavorable outcomes, and in the pattern of comorbidities in young patients. The north region had higher rates of unvaccinated patients and a lower percentage of those vaccinated with three doses in all age groups compared to other regions. The northeast region had the highest rates of patients admitted to the ICU for all age groups, while the north and northeast were the most affected by IMV requirements and in-hospital death in all age groups. This study showed that extended vaccination coverage, especially booster doses, can protect different population segments from developing severe disease since lower vaccination coverage was observed in regions with higher fatality rates.
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ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines11101568