Search Results - "de Souza, Mark S."

A Phase 1/2 Study of a Multiclade HIV-1 DNA Plasmid Prime and Recombinant Adenovirus Serotype 5 Boost Vaccine in HIV-Uninfected East Africans (RV 172) by Kibuuka, Hannah, Kimutai, Robert, Maboko, Leonard, Sawe, Fred, Schunk, Mirjam S., Kroidl, Arne, Shaffer, Douglas, Eller, Leigh Anne, Kibaya, Rukia, Eller, Michael A., Schindler, Karin B., Schuetz, Alexandra, Millard, Monica, Kroll, Jason, Dally, Len, Hoelscher, Michael, Bailer, Robert, Cox, Josephine H., Marovich, Mary, Birx, Deborah L., Graham, Barney, Michael, Nelson L., de Souza, Mark S., Robb, Merlin L.

“…Background. Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multiclade DNA…”
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Reference ranges for the clinical laboratory derived from a rural population in Kericho, Kenya by Kibaya, Rukia S, Bautista, Christian T, Sawe, Frederick K, Shaffer, Douglas N, Sateren, Warren B, Scott, Paul T, Michael, Nelson L, Robb, Merlin L, Birx, Deborah L, de Souza, Mark S

“…The conduct of Phase I/II HIV vaccine trials internationally necessitates the development of region-specific clinical reference ranges for trial enrollment and…”
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Longitudinal Analysis of Peripheral and Colonic CD161 + CD4 + T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation by Lal, Kerri G, Phuang-Ngern, Yuwadee, Suhkumvittaya, Suchada, Leeansyah, Edwin, Alrubayyi, Aljawharah, Dias, Joana, Waickman, Adam, Kim, Dohoon, Kroon, Eugène, Pinyakorn, Suteeraporn, Eller, Leigh Anne, Maciel, Jr, Milton, Rerknimitr, Rungsun, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark S S, Nitayaphan, Sorachai, Ake, Julie A, Vasan, Sandhya, Robb, Merlin L, Ananworanich, Jintanat, Sandberg, Johan K, Schuetz, Alexandra, Eller, Michael A, Paquin-Proulx, Dominic

“…CD161 expression on CD4 T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18…”
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Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand by Robb, Merlin L, Eller, Leigh A, Kibuuka, Hannah, Rono, Kathleen, Maganga, Lucas, Nitayaphan, Sorachai, Kroon, Eugene, Sawe, Fred K, Sinei, Samuel, Sriplienchan, Somchai, Jagodzinski, Linda L, Malia, Jennifer, Manak, Mark, de Souza, Mark S, Tovanabutra, Sodsai, Sanders-Buell, Eric, Rolland, Morgane, Dorsey-Spitz, Julie, Eller, Michael A, Milazzo, Mark, Li, Qun, Lewandowski, Andrew, Wu, Hao, Swann, Edith, O'Connell, Robert J, Peel, Sheila, Dawson, Peter, Kim, Jerome H, Michael, Nelson L

“…Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding of acute HIV-1 infection may be…”
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Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccines by Chung, Amy W, Ghebremichael, Musie, Robinson, Hannah, Brown, Eric, Choi, Ickwon, Lane, Sophie, Dugast, Anne-Sophie, Schoen, Matthew K, Rolland, Morgane, Suscovich, Todd J, Mahan, Alison E, Liao, Larry, Streeck, Hendrik, Andrews, Charla, Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, de Souza, Mark S, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Francis, Donald, Michael, Nelson L, Kim, Jerome H, Bailey-Kellogg, Chris, Ackerman, Margaret E, Alter, Galit

“…The human phase 2B RV144 ALVAC-HIV vCP1521/AIDSVAX B/E vaccine trial, held in Thailand, resulted in an estimated 31.2% efficacy against HIV infection. By…”
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Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations by Akapirat, Siriwat, Karnasuta, Chitraporn, Vasan, Sandhya, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Madnote, Sirinan, Savadsuk, Hathairat, Rittiroongrad, Surawach, Puangkaew, Jiraporn, Phogat, Sanjay, Tartaglia, James, Sinangil, Faruk, de Souza, Mark S, Excler, Jean-Louis, Kim, Jerome H, Robb, Merlin L, Michael, Nelson L, Ngauy, Viseth, O'Connell, Robert J, Karasavvas, Nicos

“…Sexual transmission is the principal driver of the human immunodeficiency virus (HIV) pandemic. Understanding HIV vaccine-induced immune responses at mucosal…”
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Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate by Currier, Jeffrey R, Ngauy, Viseth, de Souza, Mark S, Ratto-Kim, Silvia, Cox, Josephine H, Polonis, Victoria R, Earl, Patricia, Moss, Bernard, Peel, Sheila, Slike, Bonnie, Sriplienchan, Somchai, Thongcharoen, Prasert, Paris, Robert M, Robb, Merlin L, Kim, Jerome, Michael, Nelson L, Marovich, Mary A

“…We conducted a Phase I randomized, dose-escalation, route-comparison trial of MVA-CMDR, a candidate HIV-1 vaccine based on a recombinant modified vaccinia…”
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Estimating HIV-1 incidence in Japan from the proportion of recent infections by Matsuoka, Saori, Nagashima, Mami, Sadamasu, Kenji, Mori, Haruyo, Kawahata, Takuya, Zaitsu, Shuichi, Nakamura, Asako, de Souza, Mark S., Matano, Tetsuro

“…The first step of the UNAIDS/WHO 90-90-90 targets to encourage early diagnosis with treatment for the control of HIV-1 epidemic is to achieve 90% HIV-1…”
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Molecular Evolution of the HIV-1 Thai Epidemic between the Time of RV144 Immunogen Selection to the Execution of the Vaccine Efficacy Trial by Kijak, Gustavo H, Tovanabutra, Sodsai, Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Eamsila, Chirapa, Kunasol, Prayura, Khamboonruang, Chirasak, Thongcharoen, Prasert, Namwat, Chawetsan, Premsri, Nakorn, Benenson, Michael, Morgan, Patricia, Bose, Meera, Sanders-Buell, Eric, Paris, Robert, Robb, Merlin L, Birx, Deborah L, De Souza, Mark S, McCutchan, Francine E, Michael, Nelson L, Kim, Jerome H

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Reference intervals in healthy adult Ugandan blood donors and their impact on conducting international vaccine trials by Eller, Leigh Anne, Eller, Michael A, Ouma, Benson, Kataaha, Peter, Kyabaggu, Denis, Tumusiime, Richard, Wandege, Joseph, Sanya, Ronald, Sateren, Warren B, Wabwire-Mangen, Fred, Kibuuka, Hannah, Robb, Merlin L, Michael, Nelson L, de Souza, Mark S

“…Clinical trials are increasingly being conducted internationally. In order to ensure enrollment of healthy participants and proper safety evaluation of vaccine…”
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Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E by Ratto-Kim, Silvia, de Souza, Mark S, Currier, Jeffrey R, Karasavvas, Nicos, Sidney, John, Rolland, Morgane, Valencia-Micolta, Anais, Madnote, Sirinan, Sette, Alessandro, Nitayaphan, Sorachai, Pitisuttuthum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, O'Connell, Robert, Michael, Nelson, Robb, Merlin L, Marovich, Mary, Kim, Jerome H

“…We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed…”
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Sex and Urbanicity Contribute to Variation in Lymphocyte Distribution across Ugandan Populations by Naluyima, Prossy, Eller, Leigh Anne, Ouma, Benson J, Kyabaggu, Denis, Kataaha, Peter, Guwatudde, David, Kibuuka, Hannah, Wabwire-Mangen, Fred, Robb, Merlin L, Michael, Nelson L, de Souza, Mark S, Sandberg, Johan K, Eller, Michael A

“…Management of patient care and interpretation of research data require evaluation of laboratory results in the context of reference data from populations with…”
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IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens by Karasavvas, Nicos, Karnasuta, Chitraporn, Savadsuk, Hathairat, Madnote, Sirinan, Inthawong, Dutsadee, Chantakulkij, Somsak, Rittiroongrad, Surawach, Nitayaphan, Sorachai, Pitisuttithum, Punnee, Thongcharoen, Prasert, Siriyanon, Vinai, Andrews, Charla A, Barnett, Susan W, Tartaglia, James, Sinangil, Faruk, Francis, Donald P, Robb, Merlin L, Michael, Nelson L, Ngauy, Viseth, de Souza, Mark S, Paris, Robert M, Excler, Jean-Louis, Kim, Jerome H, O'Connell, Robert J

“…RV144 correlates of risk analysis showed that IgG antibodies to gp70V1V2 scaffolds inversely correlated with risk of HIV acquisition. We investigated IgG…”
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HIV-1 envelope resistance to proteasomal cleavage: implications for vaccine induced immune responses by Steers, Nicholas J, Ratto-Kim, Silvia, de Souza, Mark S, Currier, Jeffrey R, Kim, Jerome H, Michael, Nelson L, Alving, Carl R, Rao, Mangala

“…Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to…”
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Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial by Haynes, Barton F, Gilbert, Peter B, McElrath, M. Juliana, Zolla-Pazner, Susan, Tomaras, Georgia D, Alam, S. Munir, Evans, David T, Montefiori, David C, Karnasuta, Chitraporn, Sutthent, Ruengpueng, Liao, Hua-Xin, DeVico, Anthony L, Lewis, George K, Williams, Constance, Pinter, Abraham, Fong, Youyi, Janes, Holly, DeCamp, Allan, Huang, Yunda, Rao, Mangala, Billings, Erik, Karasavvas, Nicos, Robb, Merlin L, Ngauy, Viseth, de Souza, Mark S, Paris, Robert, Ferrari, Guido, Bailer, Robert T, Soderberg, Kelly A, Andrews, Charla, Berman, Phillip W, Frahm, Nicole, De Rosa, Stephen C, Alpert, Michael D, Yates, Nicole L, Shen, Xiaoying, Koup, Richard A, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Nitayaphan, Sorachai, Rerks-Ngarm, Supachai, Michael, Nelson L, Kim, Jerome H

“…This analysis of correlates of the risk of HIV-1 infection in the RV144 vaccine trial identifies hypotheses for improving efficacy. The data indicate key roles…”
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Human Immunodeficiency Virus Type 1 Infection Is Associated with Increased NK Cell Polyfunctionality and Higher Levels of KIR3DL1+ NK Cells in Ugandans Carrying the HLA-B Bw4 Motif by ELLER, Michael A, KOEHLER, Rebecca N, CURRIER, Jeffrey R, SANDBERG, Johan K, KIJAK, Gustavo H, ANNE ELLER, Leigh, GUWATUDDE, David, MAROVICH, Mary A, MICHAEL, Nelson L, DE SOUZA, Mark S, WABWIRE-MANGEN, Fred, ROBB, Merlin L

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Biologic and Genetic Characterization of a Panel of 60 Human Immunodeficiency Virus Type 1 Isolates, Representing Clades A, B, C, D, CRF01_AE, and CRF02_AG, for the Development and Assessment of Candidate Vaccines by BROWN, Bruce K, DARDEN, Janice M, TOVANABUTRA, Sodsai, OBLANDER, Tamara, FROST, Julie, SANDERS-BUELL, Eric, DE SOUZA, Mark S, BIRX, Deborah L, MCCUTCHAN, Francine E, POLONIS, Victoria R

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Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Resistance Is Associated with the Syncytium-Inducing Phenotype and Lower CD4 Cell Counts in Subtype CRF01_AE-Infected Patients by Polonis, Victoria R, de Souza, Mark S, Darden, Janice M, Chantakulkij, Somsak, Chuenchitra, Thippawan, Nitayaphan, Sorachai, Brown, Arthur E, Robb, Merlin L, Birx, Deborah L

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Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation by Schuetz, Alexandra, Deleage, Claire, Sereti, Irini, Rerknimitr, Rungsun, Phanuphak, Nittaya, Phuang-Ngern, Yuwadee, Estes, Jacob D, Sandler, Netanya G, Sukhumvittaya, Suchada, Marovich, Mary, Jongrakthaitae, Surat, Akapirat, Siriwat, Fletscher, James L K, Kroon, Eugene, Dewar, Robin, Trichavaroj, Rapee, Chomchey, Nitiya, Douek, Daniel C, O Connell, Robert J, Ngauy, Viseth, Robb, Merlin L, Phanuphak, Praphan, Michael, Nelson L, Excler, Jean-Louis, Kim, Jerome H, de Souza, Mark S, Ananworanich, Jintanat

“…Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is…”
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Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology by de Souza, Mark S., Pinyakorn, Suteeraporn, Akapirat, Siriwat, Pattanachaiwit, Supanit, Fletcher, James L. K., Chomchey, Nitiya, Kroon, Eugene D., Ubolyam, Sasiwimol, Michael, Nelson L., Robb, Merlin L., Phanuphak, Praphan, Kim, Jerome H., Phanuphak, Nittaya, Ananworanich, Jintanat

“…Background. Third- and fourth-generation immunoassays (IAs) are widely used in the diagnosis of human immunodeficiency virus (HIV) infection. Antiretroviral…”
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