Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile

Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile

Male obesity has a negative correlation with plasma testosterone (T) levels and sexual function (SF). To evaluate the effect of weight loss through bariatric surgery (BS) on SF, low T symptoms, and hormonal profiles in obese men. Thirty-three men who underwent BS participated in this cohort study. B...

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Bibliographic Details
Published in:Sexual medicine Vol. 9; no. 4; p. 100400
Main Authors: Machado, Felipe Pioner, Rhoden, Ernani Luis, Pioner, Sérgio Ricardo, Halmenschlager, Graziele, de Souza, Luis Vinicius Bastos, Lisot, Bruno Chao, Drachler, Igor Pires
Format: Journal Article
Language:English
Published: Elsevier Inc 01-08-2021
Elsevier
Oxford University Press
Subjects:
Bariatric Surgery
Erectile Function
Low T Symptoms
Original Research
Sexual Function
Testosterone
Weight Loss
CRP
TT
NO
E2
FT
ADAM
BS
SD
BT
MOSH
SF
GBP
SG
T
MD
FSH
HbA1c
ED
Bariatric Surgery
PDE5
Erectile Function
IIEF
Sexual Function
AMS
IR
Low T Symptoms
Testosterone
MetS
Weight Loss
LH
SHBG
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Summary:Male obesity has a negative correlation with plasma testosterone (T) levels and sexual function (SF). To evaluate the effect of weight loss through bariatric surgery (BS) on SF, low T symptoms, and hormonal profiles in obese men. Thirty-three men who underwent BS participated in this cohort study. Before surgery, all participants underwent clinical examinations, including anthropometric, lipid, glycemic, and hormonal evaluations. SF was evaluated using the International Index of Erectile Function (IIEF) questionnaire; low T symptoms were evaluated using the Aging Males’ Symptoms (AMS) and Androgen Deficiency in the Aging Male (ADAM) questionnaires. The participants were reevaluated 6 months post-surgery. Sex hormone profile, SF, and low T symptoms After BS, a significant increase in mean total T (201 ± 111–548 ± 190 ng/dL, P < .001), free T (5.8 ± 2.8–9.3 ± 3.4 ng/dL, P < .001), bioavailable T (110.3 ± 57.8–198.6 ± 74.3 ng/dL, P < .001), and sexual hormone-binding globulin (19.8 ± 13.7–54.6 ± 23.2 nmol/L, P < .001) levels. There was a significant decrease in estradiol (64.6 ± 27.4–29.2 ± 20.0 [pg/mL], P < .001). SF significantly improved. The total IIEF score increased 5.2 points (62.3 ± 7.4–67.5 ± 7.4, P = .004), erectile function subdomain increased 2.4 points (25.7 ± 4.1–28.1 ± 3.9, P = .011), desire subdomain increased 1.0 points (8.3 ± 1.5–9.3 ± 1.6, P = .006), and intercourse satisfaction subdomain increased 1.2 points (11.4 ± 1.9–12.6 ± 1.8, P = .012). Post-surgery, a 44% reduction (P = .001) was observed in the positive ADAM questionnaire, and improvements in all domains of the AMS questionnaire were found (P < .001). Significant weight loss through BS improves erectile function, hormonal profile, and symptoms of T deficiency. Machado FP, Rhoden EL, Pioner SR, et al. Weight Loss Through Bariatric Surgery in Men Presents Beneficial Effects on Sexual Function, Symptoms of Testosterone Deficiency, and Hormonal Profile. Sex Med 2021;9:100400.
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ISSN:2050-1161
2050-1161
DOI:10.1016/j.esxm.2021.100400