Search Results - "de Souza, Ângelo Malachias"
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Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines
Published in Brazilian Journal of Pharmaceutical Sciences (01-01-2021)“…Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting…”
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Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity
Published in Biomedicine & pharmacotherapy (01-12-2020)“…[Display omitted] •Design of a novel nanostructured lipid carriers (NLC) formulation loading DOX, DHA, and TS.•Hydrophobic ion-pairing with TS allows high DOX…”
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Sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer
Published in Life sciences (1973) (01-09-2019)“…In this work, it was sought to determine if there was synergism between doxorubicin (DOX), a well-known antineoplastic, and sclareol (SC), a diterpene from…”
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Modifying internal organization and surface morphology of siRNA lipoplexes by sodium alginate addition for efficient siRNA delivery
Published in Journal of colloid and interface science (22-03-2019)“…[Display omitted] Vectorized small interfering RNAs (siRNAs) are widely used to induce specific mRNA degradation in the intracellular compartment of eukaryotic…”
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