Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays

Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 22312
Main Authors:	Pinto, Isabelle C., Seibert, Janaína B., Pinto, Luciano S., Santos, Vagner R., de Sousa, Rafaela F., Sousa, Lucas R. D., Amparo, Tatiane R., dos Santos, Viviane M. R., do Nascimento, Andrea M., de Souza, Gustavo Henrique Bianco, Vasconcellos, Walisson A., Vieira, Paula M. A., Andrade, Ângela L.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18-12-2020 Nature Publishing Group Nature Portfolio
Subjects:	631/1647 631/449 631/61 692/308 692/700 Anacardiaceae - chemistry Biocompatibility Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Brazil Cement Composite materials Compressive Strength Cytotoxicity Diffusion coefficient Drug delivery Flavonoids Fourier analysis Fourier transforms Fruit - chemistry Glass Ionomer Cements - chemical synthesis Glass Ionomer Cements - chemistry Glass Ionomer Cements - pharmacology Humanities and Social Sciences Humans Infrared spectroscopy Materials Testing Mechanical properties Microorganisms Microscopy, Electron, Scanning Mouth - chemistry Mouth - drug effects Mouth - microbiology multidisciplinary Oral cavity Plant Extracts - chemistry Plant Extracts - pharmacology Scanning electron microscopy Science Science (multidisciplinary) Spectroscopy, Fourier Transform Infrared Thermal analysis Brazil
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Summary:	Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC–QTOF–MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the M t /M ∞ relatively to t , at a diffusion coefficient of 1.406 × 10 –6 cm 2 s −1 . The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-79257-3