Search Results - "de Sousa, PA"

Expression of FBN1 during adipogenesis: Relevance to the lipodystrophy phenotype in Marfan syndrome and related conditions by Davis, Margaret R., Arner, Erik, Duffy, Cairnan R.E., De Sousa, Paul A., Dahlman, Ingrid, Arner, Peter, Summers, Kim M.

“…Fibrillin-1 is a large glycoprotein encoded by the FBN1 gene in humans. It provides strength and elasticity to connective tissues and is involved in regulating…”
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Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis by Davis, Margaret R., Arner, Erik, Duffy, Cairnan R.E., De Sousa, Paul A., Dahlman, Ingrid, Arner, Peter, Summers, Kim M.

“…This article contains data related to the research article entitled “Expression of FBN1 during adipogenesis: relevance to the lipodystrophy phenotype in Marfan…”
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Sensitivity of bovine blastocyst gene expression patterns to culture environments assessed by differential display RT-PCR by Natale, DR, De Sousa, PA, Westhusin, ME, Watson, AJ

“…The use of culture media to support the development of preimplantation embryos to the blastocyst stage is often associated with detrimental effects on normal…”
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Somatic cell nuclear transfer by Wilmut, I, Beaujean, N, de Sousa, P. A, Dinnyes, A, King, T. J, Paterson, L. A, Wells, D. N, Young, L. E

“…Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm,…”
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Embryo development and establishment of pregnancy after embryo transfer in pigs: coping with limitations in the availability of viable embryos by King, TJ, Dobrinsky, Zhu, J, Finlayson, HA, Bosma, W, Harkness, L, Ritchie, WA, Travers, A, McCorquodale, C, Day, BN, Dinnyes, A, De Sousa, PA, Wilmut, I

“…Embryo transfer and pregnancy maintenance strategies in pigs were evaluated with reference to situations in which limited numbers of viable embryos or…”
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Evaluation of Gestational Deficiencies in Cloned Sheep Fetuses and Placentae by DE SOUSA, Paul A, KING, Tim, HARKNESS, Linda, YOUNG, Lorraine E, WALKER, Simon K, WILMUT, Ian

“…Sheep fetal development at 35 days of gestation was examined following natural mating, in vitro production (IVP) of fertilized embryos, or somatic cell nuclear…”
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Cardiac Malformation in Neonatal Mice Lacking Connexin43 by Reaume, Andrew G., de Sousa, Paul A., Kulkarni, Sarang, Langille, B. Lowell, Zhu, Daguang, Davies, Tyler C., Juneja, Subhash C., Kidder, Gerald M., Rossant, Janet

“…Gap junctions are made up of connexin proteins, which comprise a multigene family in mammals. Targeted mutagenesis of connexin43 (Cx43), one of the most…”
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Somatic Cell Nuclear Transfer in the Pig: Control of Pronuclear Formation and Integration with Improved Methods for Activation and Maintenance of Pregnancy by DE SOUSA, Paul A, DOBRINSKY, John R, GASPARRINI, Bianca, HARKNESS, Linda, JOHNSTON, Paul, RITCHIE, Marjorie, RITCHIE, William A, TRAVERS, Ailsa, ALBERTINI, David, DINNYES, Andras, KING, Timothy J, WILMUT, Ian, JIE ZHU, ARCHIBALD, Alan L, AINSLIE, Alison, BOSMA, Wim, BOWERING, June, BRACKEN, John, FERRIER, Patricia M, FLETCHER, Judy

“…To clone a pig from somatic cells, we first validated an electrical activation method for use on ovulated oocytes. We then evaluated delayed versus…”
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Human cloning: can it be made safe? by Rhind, Susan M, Taylor, Jane E, De Sousa, Paul A, King, Tim J, McGarry, Michelle, Wilmut, Ian

“…There are continued claims of attempts to clone humans using nuclear transfer, despite the serious problems that have been encountered in cloning other…”
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Brain-derived neurotrophic factor promotes bovine oocyte cytoplasmic competence for embryo development by Martins da Silva, S J, Gardner, J O, Taylor, J E, Springbett, A, De Sousa, P A, Anderson, R A

“…The ability of an oocyte to support early embryonic development requires both nuclear and cytoplasmic maturation. We have investigated the effects of…”
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Improvement of an Electrical Activation Protocol for Porcine Oocytes by JIE ZHU, TELFER, Evelyn E, FLETCHER, Judy, SPRINGBETT, Anthea, DOBRINSKY, John R, DE SOUSA, Paul A, WILMUT, Lan

“…Factors influencing pig oocyte activation by electrical stimulation were evaluated by their effect on the development of parthenogenetic embryos to the…”
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Cloned Mice Derived from Embryonic Stem Cell Karyoplasts and Activated Cytoplasts Prepared by Induced Enucleation by Gasparrini, B, Gao, S, Ainslie, A, Fletcher, J, McGarry, M, Ritchie, W. A, Springbett, A. J, Overström, E. W, Wilmut, I, De Sousa, P. A

“…Our objective was to induce enucleation (IE) of activated mouse oocytes to yield cytoplasts capable of supporting development following nuclear transfer…”
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Optimising the therapeutic safety of human embryonic stem cells through the evolution of defined culture systems supporting their isolation by De Sousa, Paul A

“…Realising the therapeutic promise of embryo-derived stem cells is absolutely dependent on the evolution of defined and quality assured in vitro culture systems…”
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Transient Expression of Translation Initiation Factor eIF-4C during the 2-Cell Stage of the Preimplantation Mouse Embryo: Identification by mRNA Differential Display and the Role of DNA Replication in Zygotic Gene Activation by Davis, Jr, Warren, De Sousa, Paul A., Schultz, Richard M.

“…Zygotic gene activation (ZGA) definitely occurs by the 2-cell stage in the mouse embryo. Analysis of protein synthesis by two-dimensional gel electrophoresis…”
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A Personal Perspective: Is Bullying Still a Problem in Medicine? by Taylor-Robinson, Simon D, De Sousa Lopes, Paulo A, Zdravkov, Jey, Harrison, Rachel

“…Bullying of whatever form should have no place in the Medical Profession. Reforms to junior doctor training and reduction in working hours have helped to…”
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Analysis of variation in relative mRNA abundance for specific gene transcripts in single bovine oocytes and early embryos by De Sousa, P.A, Westhusin, M.E, Watson, A.J

“…Variation in the abundance of a specific gene transcript was assessed in single bovine oocytes and in vitro–derived blastocysts. Transcripts encoding the…”
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Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos by De Sousa, P.A. (University of Western Ontario, London, Ontario, Canada.), Watson, A.J, Schultz, R.M

“…In the present study the abundance of mRNAs for eukaryotic translation initiation factors eIF-1A (formerly known as eIF-4C), -2α, -4A, -4E, and -5 was…”
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Gene expression regulating blastocyst formation by Watson, A.J, Westhusin, M.E, De Sousa, P.A, Betts, D.H, Barcroft, L.C

“…Development of embryos to the blastocyst stage is a critical event in the early lives of all eutherian mammalian species. Blastocyst formation is essential for…”
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Temporal patterns of embryonic gene expression and their dependence on oogenetic factors by De Sousa, P.A., Caveney, A., Westhusin, M.E., Watson, A.J.

“…Successful development of a fertilized egg beyond early cleavage divisions requires the de novo initiation and subsequent regulation of embryonic…”
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Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI) by Andrews, PW, Baker, Benvinisty, Miranda, Bruce, Brüstle, Choi, Choi, Y-M, Crook, JM, de Sousa, PA, Dvorak, Freund, Firpo, Furue, MK, Gokhale, Ha, H-Y, Han, Haupt, Healy, Hei, DJ, Hovatta, Hunt, Hwang, S-M, Inamdar, MS, Isasi, RM, Jaconi, Jekerle, Kamthorn, Kibbey, MC, Knezevic, Knowles, BB, Koo, S-K, Laabi, Leopoldo, Liu, Lomax, GP, Loring, JF, Ludwig, TE, Montgomery, Mummery, Nagy, Nakamura, Nakatsuji, Oh, Oh, S-K, Otonkoski, Pera, Peschanski, Pranke, Rajala, KM, Rao, Ruttachuk, Reubinoff, Ricco, Rooke, Sipp, Stacey, GN, Suemori, Takahashi, TA, Takada, Talib, Tannenbaum, Yuan, B-Z, Zeng, Zhou

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