Search Results - "de Sousa, Julien"

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease by Joosten, Antoine, Decroocq, Camille, de Sousa, Julien, Schneider, Jérémy P., Etamé, Emile, Bodlenner, Anne, Butters, Terry D., Compain, Philippe

“…A series of 18 mono‐ to 14‐valent iminosugars with different ligands, scaffolds, and alkyl spacer lengths have been synthesized and evaluated as inhibitors and…”
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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents by Santoni, Gianluca, de Sousa, Julien, de la Mora, Eugenio, Dias, José, Jean, Ludovic, Sussman, Joel L, Silman, Israel, Renard, Pierre-Yves, Brown, Richard C. D, Weik, Martin, Baati, Rachid, Nachon, Florian

“…Acetylcholinesterase (AChE), a key enzyme in the central and peripheral nervous systems, is the principal target of organophosphorus nerve agents. Quaternary…”
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Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors by Compain, Philippe, Decroocq, Camille, Joosten, Antoine, de Sousa, Julien, Rodríguez-Lucena, David, Butters, Terry D., Bertrand, Johanna, Clément, Romain, Boinot, Clément, Becq, Frédéric, Norez, Caroline

“…Cystic fibrosis is caused by a mutation in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. N‐butyl 1‐deoxynojirimycin…”
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Buchwald-Hartwig Amination Approach for the Synthesis of Functionalized 1,2,3,4-Tetrahydroacridine Derivatives by de Sousa, Julien, Brown, Richard C. D., Baati, Rachid

“…Electrophilic 1,2,3,4‐tetrahydroacridin‐9‐yl trifluoromethanesulfonates have been prepared and applied for the first time in the synthesis of functionalized…”
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Inside Cover: Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors (ChemBioChem 15/2013) by Compain, Philippe, Decroocq, Camille, Joosten, Antoine, de Sousa, Julien, Rodríguez-Lucena, David, Butters, Terry D., Bertrand, Johanna, Clément, Romain, Boinot, Clément, Becq, Frédéric, Norez, Caroline

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Design, synthesis and biological of novel uncharged bifunctional hybrid reactivators for organophosphorous nerve agent-inhibited human acetylcholinesterase by De Sousa, Julien Alain Albino

“…Remediation of both acute and chronic intoxications by organophosphorus nerve agents, both chemical warfare agents and pesticides, continues to be a challenge…”
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