Search Results - "de Sousa, Caren Nádia Soares"

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness by Macedo, Danielle, Filho, Adriano José Maia Chaves, Soares de Sousa, Caren Nádia, Quevedo, João, Barichello, Tatiana, Júnior, Hélio Vitoriano Nobre, Freitas de Lucena, David

“…Abstract Objectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of…”
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Augmentation therapy with alpha-lipoic acid and desvenlafaxine: A future target for treatment of depression? by Silva, Márcia Calheiros Chaves, de Sousa, Caren Nádia Soares, Sampaio, Luis Rafael Leite, Ximenes, Naiara Coelho, Araújo, Paulo Victor Pontes, da Silva, Jéssica Calheiros, de Oliveira, Suzyana Lima, Sousa, Francisca Cléa Florenço, Macêdo, Danielle Silveira, Vasconcelos, Silvânia Maria Mendes

“…This study was designed to investigate the possible antidepressant effects of the antioxidant alpha-lipoic acid (ALA) as a stand-alone treatment or in…”
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Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat by de Araújo, Dayane Pessoa, De Sousa, Caren Nádia Soares, Araújo, Paulo Victor Pontes, Menezes, Carlos Eduardo de Souza, Rodrigues, Francisca Taciana Sousa, Escudeiro, Sarah Souza, Lima, Nicole Brito Cortez, Patrocínio, Manoel Claúdio Azevedo, Aguiar, Lissiana Magna Vasconcelos, Viana, Glauce Socorro de Barros, Vasconcelos, Silvânia Maria Mendes

“…This study aimed to investigate behavioral and neurochemical effects of α-lipoic acid (100 mg/kg or 200 mg/kg) alone or associated with L-DOPA using an animal…”
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Involvement of oxidative pathways and BDNF in the antidepressant effect of carvedilol in a depression model induced by chronic unpredictable stress by de Sousa, Caren Nádia Soares, Medeiros, Ingridy da Silva, Vasconcelos, Germana Silva, de Aquino, Gabriel Angelo, Cysne Filho, Francisco Maurício Sales, de Almeida Cysne, Jamily Cunha, Macêdo, Danielle Silveira, Vasconcelos, Silvânia Maria Mendes

“…Rationale Depression is a severe psychiatric disorder with oxidative imbalance and neurotrophic deficits as underlying mechanisms. Objectives Based on the…”
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Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression by Sousa, Caren Nádia Soares de, Meneses, Lucas Nascimento, Vasconcelos, Germana Silva, Silva, Márcia Calheiros Chaves, Silva, Jéssica Calheiros da, Macêdo, Danielle, de Lucena, David Freitas, Vasconcelos, Silvânia Maria Mendes

“…Abstract Brain derived neurotrophic factor (BDNF) is linked to the pathophysiology of depression. We hypothesized that BDNF is one of the neurobiological…”
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Alpha-lipoic acid in the treatment of psychiatric and neurological disorders: a systematic review by de Sousa, Caren Nádia Soares, da Silva Leite, Cláudio Manuel Gonçalves, da Silva Medeiros, Ingridy, Vasconcelos, Luna Costa, Cabral, Lucas Moraes, Patrocínio, Cláudio Felipe Vasconcelos, Patrocínio, Marianna Letícia Vasconcelos, Mouaffak, Fayçal, Kebir, Oussama, Macedo, Danielle, Patrocínio, Manoel Cláudio Azevedo, Vasconcelos, Silvânia Maria Mendes

“…Despite the existence of many preclinical studies, scientific evidence is lacking on the clinical use of alpha-lipoic acid (ALA) for central nervous system…”
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Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone by Oliveira, Tatiana de Queiroz, Sousa, Caren Nádia Soares de, Vasconcelos, Germana Silva, de Sousa, Luciene Costa, de Oliveira, Anneheydi Araújo, Patrocínio, Cláudio Felipe Vasconcelos, Medeiros, Ingridy da Silva, Honório Júnior, José Eduardo Ribeiro, Maes, Michael, Macedo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…Abstract Background Depression is accompanied by activated neuro-oxidative and neuro-nitrosative pathways, while targeting these pathways has clinical efficacy…”
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Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model by de Sousa, Caren Nádia Soares, da Silva Medeiros, Ingridy, Vasconcelos, Germana Silva, de Aquino, Gabriel Ângelo, Filho, Francisco Maurício Sales Cysne, de Almeida, Jamily Cunha, Alves, Ana Paula Negreiros Nunes, Macêdo, Danielle S., Leal, Luzia Kalyne Almeida Moreira, Vasconcelos, Silvânia Maria Mendes

“…Anxiety disorders are the most prevalent psychiatric disorders being also a comorbid state of other diseases. We aimed to evaluate the anxiolytic-like effects…”
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Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression by de Sousa, Caren Nádia Soares, Meneses, Lucas Nascimento, Vasconcelos, Germana Silva, da Silva Medeiros, Ingridy, Silva, Márcia Calheiros Chaves, Mouaffak, Fayçal, Kebir, Oussama, da Silva Leite, Cláudio Manuel Gonçalves, Patrocinio, Manoel Cláudio Azevedo, Macedo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…Cognitive impairment is present in patients with depression. We hypothesized that alpha-lipoic acid (ALA) can reduce cognitive impairment, especially when…”
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Involvement of monoaminergic systems in anxiolytic and antidepressive activities of the standardized extract of Cocos nucifera L by Lima, Eliane Brito Cortez, de Sousa, Caren Nádia Soares, Meneses, Lucas Nascimento, e Silva Pereira, Yuri Freitas, Matos, Natália Castelo Branco, de Freitas, Rayanne Brito, Lima, Nycole Brito Cortez, Patrocínio, Manoel Cláudio Azevedo, Leal, Luzia Kalyne Almeida Moreira, Viana, Glauce Socorro Barros, Vasconcelos, Silvânia Maria Mendes

“…Extracts from the husk fiber of Cocos nucifera are used in folk medicine, but their actions on the central nervous system have not been studied. Here, the…”
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Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms by Vasconcelos, Germana Silva, Ximenes, Naiara Coelho, de Sousa, Caren Nádia Soares, Oliveira, Tatiana de Queiroz, Lima, Laio Ladislau Lopes, de Lucena, David Freitas, Gama, Clarissa Severino, Macêdo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…Abstract Oxidative stress has important implications in schizophrenia. Alpha-lipoic acid (ALA) is a natural antioxidant synthesized in human tissues with…”
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Advantages of the Alpha-lipoic Acid Association with Chlorpromazine in a Model of Schizophrenia Induced by Ketamine in Rats: Behavioral and Oxidative Stress evidences by Sampaio, Luis Rafael Leite, Cysne Filho, Francisco Maurício Sales, de Almeida, Jamily Cunha, Diniz, Danilo dos Santos, Patrocínio, Cláudio Felipe Vasconcelos, de Sousa, Caren Nádia Soares, Patrocínio, Manoel Cláudio Azevedo, Macêdo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…•KET induced hyperlocomotion, impaired working memory and decreased prepulse inhibition associated to oxidative stress.•Pre-treatment with CP, alone or…”
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Early maternal separation enhances melanoma progression in adult female mice by immune mechanisms by Barreto, Francisco Stefânio, Ribeiro, Wesley Lyeverton Correia, Cavalcanti, Bruno Coêlho, Silva, Paulo Goberlânio de Barros, Soares de Sousa, Caren Nádia, Vasconcelos, Germana Silva, Nunes, Ana Paula Negreiros, Moraes Filho, Manoel Odorico de, Macedo, Danielle S.

“…Maternal separation (MS) is a risk factor for major depressive disorder. Both cancer and depression seem to share a common biological link. Here, we evaluated…”
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Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice by Silva, Márcia Calheiros Chaves, de Sousa, Caren Nádia Soares, Gomes, Patrícia Xavier Lima, de Oliveira, Gersilene Valente, Araújo, Fernanda Yvelize Ramos, Ximenes, Naiara Coelho, da Silva, Jéssica Calheiros, Silva Vasconcelos, Germana, Leal, Luzia Kalyne Almeida Moreira, Macêdo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…Oxidative stress is implicated in the neurobiology of depression. Here we investigated oxidative alterations in brain areas of animals submitted to the model…”
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Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice by Lima, Eliane Brito Cortez, de Sousa, Caren Nádia Soares, Vasconcelos, Germana Silva, Meneses, Lucas Nascimento, e Silva Pereira, Yuri Freitas, Ximenes, Naiara Coelho, Santos Júnior, Manuel Alves, Matos, Natália Castelo Branco, Brito, Rayanne, Miron, Diogo, Leal, Luzia Kalyne Almeida Moreira, Macêdo, Danielle, Vasconcelos, Silvânia Maria Mendes

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Effects of standard ethanolic extract from Erythrina velutina in acute cerebral ischemia in mice by Rodrigues, Francisca Taciana Sousa, de Sousa, Caren Nádia Soares, Ximenes, Naiara Coelho, Almeida, Anália Barbosa, Cabral, Lucas Moraes, Patrocínio, Cláudio Felipe Vasconcelos, Silva, Aline Holanda, Leal, Luzia Kalyne Almeida Moreira, Honório Júnior, José Eduardo Ribeiro, Macedo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…The objective of this study was to verify a possible neuroprotective effect of the ethanolic extract of Erythrina velutina (EEEV). Male Swiss mice were…”
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Lectin isolated from the red marine alga Solieria filiformis (Kützing) P.W. Gabrielson: Secondary structure and antidepressant-like effect in mice submitted to the lipopolysaccharide-induced inflammatory model of depression by Abreu, Ticiana Monteiro, Corpe, Fernanda Pires, Teles, Felipe Barros, da Conceição Rivanor, Renata Line, de Sousa, Caren Nádia Soares, da Silva Medeiros, Ingridy, de Queiroz, Ismael Nilo Lino, Figueira-Mansur, Janaina, Mota, Érika Freitas, Mohana-Borges, Ronaldo, Macedo, Danielle S., de Vasconcelos, Silvânia Maria Mendes, Júnior, José Eduardo Ribeiro Honório, Benevides, Norma Maria Barros

“…Inflammation and oxidative and nitrosative stresses are linked to depression pathogenesis. In this context, lipopolysaccharide (LPS) has been used to induce…”
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Antidepressant, antioxidant and neurotrophic properties of the standardized extract of Cocos nucifera husk fiber in mice by Lima, Eliane Brito Cortez, de Sousa, Caren Nádia Soares, Vasconcelos, Germana Silva, Meneses, Lucas Nascimento, e Silva Pereira, Yuri Freitas, Ximenes, Naiara Coelho, Santos Júnior, Manuel Alves, Matos, Natália Castelo Branco, Brito, Rayanne, Miron, Diogo, Leal, Luzia Kalyne Almeida Moreira, Macêdo, Danielle, Vasconcelos, Silvânia Maria Mendes

“…The plant Cocos nucifera and its derivatives have shown antidepressant-like effects, although its hydroalcoholic extract has not been studied with this end in…”
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