Search Results - "de Serres, Mark"

Central Nervous System Disposition and Metabolism of Fosdevirine (GSK2248761), a Non-Nucleoside Reverse Transcriptase Inhibitor: An LC-MS and Matrix-Assisted Laser Desorption/Ionization Imaging MS Investigation into Central Nervous System Toxicity by Castellino, Stephen, Groseclose, M. Reid, Sigafoos, James, Wagner, David, de Serres, Mark, Polli, Joseph W, Romach, Elizabeth, Myer, James, Hamilton, Brad

“…The CNS disposition and metabolism of Fosdevirine (FDV), an HIV non-nucleoside reverse transcriptase inhibitor, was investigated in four patients who…”
Get full text

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism by Serres, Mark De, Bowers, Gary, Boyle, Gary, Beaumont, Claire, Castellino, Steve, Sigafoos, James, Dave, Mehul, Roberts, Andrew, Shah, Vishal, Olson, Katie, Patel, Dipak, Wagner, David, Yeager, Russell, Serabjit-Singh, Cosette

“…A model that predicts human metabolism and disposition of drug candidates would be of value in early drug development. In this study, a chimeric (uPA+/+)/SCID…”
Get full text

Drug interaction profile for GSK2248761, a next generation non‐nucleoside reverse transcriptase inhibitor by Piscitelli, Steve, Kim, Joseph, Gould, Elizabeth, Lou, Yu, White, Scott, de Serres, Mark, Johnson, Mark, Zhou, Xiao‐Jian, Pietropaolo, Keith, Mayers, Douglas

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In healthy subjects, GSK2248761 was shown to be safe and well tolerated with single doses up to 1200 mg once daily…”
Get full text

The disposition and metabolism of GW695634: A non-nucleoside reverse transcriptase inhibitor (NNRTi) for treatment of HIV/AIDS by de Serres, Mark, Moss, Lee, Sigafoos, James, Sefler, Andrea, Castellino, Stephen, Bowers, Gary, Serabjit-Singh, Cosette

“…GW695634 is the prodrug of GW678248, a novel non-nucleoside reverse transcriptase inhibitor with potent antiviral activity against HIV/AIDS efavirenz- and…”
Get full text

Morphologic characterization of PhoenixBio (uPA+/+/SCID) humanized liver chimeric mouse model by Peterson, Richard A, Krull, David L, Brown, H Roger, de Serres, Mark

“…Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio (uPA(+/+)/SCID) mouse model show robust replacement and expansion with human…”
Get more information

Immunogenicity of Thrombopoietin Mimetic Peptide GW395058 in BALB/c Mice and New Zealand White Rabbits: Evaluation of the Potential for Thrombopoietin Neutralizing Antibody Production in Man by De Serres, Mark, Ellis, Byron, Dillberger, John E., Rudolph, Sharon K., Hutchins, Jeff T., Boytos, Christine M., Weigl, Debra L., DePrince, Randolph B.

“…Administration of exogenous proteins and peptides as therapeutics carries with it the potential for immune system recognition and the development of…”
Get full text

Assessment of cryopreserved hepatocytes as an alternative to fresh hepatocytes for comparative interspecies metabolism studies with suitable acceptance criteria by Cheng, Ziqiang Zack, Herron, Christine E, Bowers, Gary, de Serres, Mark

“…Fresh hepatocytes have been the choice for interspecies comparative drug metabolism studies. Cryopreserved hepatocytes represent a readily available…”
Get more information

The Pharmacokinetics and Pharmacodynamics of GW395058, a Peptide Agonist of the Thrombopoietin Receptor, in the Dog, a Large‐Animal Model of Chemotherapy‐Induced Thrombocytopenia by Case, Beth C., Hauck, Marlene L., Yeager, Russell L., Simkins, Anita H., de Serres, Mark, Schmith, Virginia D., Dillberger, John E., Page, Rodney L.

“…GW395058, a PEGylated peptide agonist of the thrombopoietin receptor, stimulates megakaryocytopoiesis and has previously been shown to increase platelet counts…”
Get full text

Pharmacokinetics and Hematological Effects of the PEGylated Thrombopoietin Peptide Mimetic GW395058 in Rats and Monkeys After Intravenous or Subcutaneous Administration by de Serres, Mark, Yeager, Russ L., Dillberger, John E., Lalonde, Guy, Gardner, Guy H., Rubens, Cathleen A., Simkins, Anita H., Sailstad, Jeffry M., McNulty, Michael J., Woolley, Joseph L.

“…GW395058, a potent PEGylated peptide human thrombopoietin receptor (HuTPOr) agonist in vitro, is being evaluated for the treatment of thrombocytopenia…”
Get full text

Development of a Novel Scintillation Proximity Competitive Hybridization Assay for the Determination of Phosphorothioate Antisense Oligonucleotide Plasma Concentrations in a Toxicokinetic Study by de Serres, Mark, McNulty, Michael J., Christensen, Laura, Zon, Gerald, Findlay, John W.A.

“…A novel scintillation proximity competitive hybridization assay was developed for determining plasma concentrations of compound 4003W94, a 15-base…”
Get full text

Antigenic Determinant in Human Coagulation Factor IX: Immunological Screening and DNA Sequence Analysis of Recombinant Phage Map a Monoclonal Antibody to Residues 111 Through 132 of the Zymogen by McGraw, Royal, Frazier, Dan, de Serres, Mark, Reisner, Howard, Stafford, Darrell

“…As an approach to the study of structure-function relationships in the normal and defective forms of human coagulation factor IX, we have begun to develop a…”
Get full text