Search Results - "de Santo, Carmela"

Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients by Khanna, Swati, Graef, Suzanne, Mussai, Francis, Thomas, Anish, Wali, Neha, Yenidunya, Bahar Guliz, Yuan, Constance, Morrow, Betsy, Zhang, Jingli, Korangy, Firouzeh, Greten, Tim F, Steinberg, Seth M, Stetler-Stevenson, Maryalice, Middleton, Gary, De Santo, Carmela, Hassan, Raffit

“…The cross-talk between tumor cells, myeloid cells, and T cells can play a critical role in tumor pathogenesis and response to immunotherapies. Although the…”
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B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo by Barral, Patricia, Eckl-Dorna, Julia, Harwood, Naomi E, De Santo, Carmela, Salio, Mariolina, Illarionov, Petr, Besra, Gurdyal S, Cerundolo, Vincenzo, Batista, Facundo D

“…Highly regulated activation of B cells is required for the production of specific antibodies necessary to provide protection from pathogen infection. This…”
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712 IMPORT-201 (IMP-MEL): a phase 1 first-in-human dose finding/randomized phase 2 study of a novel iNKT agonist (PORT-2) and pembrolizumab for advanced melanoma and non-small cell lung cancer (NSCLC) by Coupe, Nicholas, Pinato, David J, Fairchild, Justin, Poe, Russell, Browne, Carri, Innaimo, Steven, Thompson, David, Gileadi, Uzi, Santo, Carmela De, Kramer, Robert, Walters, Ian, Middleton, Mark R

“…BackgroundInvariant natural killer T-cells (iNKTs) share features of NK-like cells and T-cells, playing a role in both innate and adaptive immune responses…”
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Molecular basis and current strategies of therapeutic arginine depletion for cancer by Fultang, Livingstone, Vardon, Ashley, De Santo, Carmela, Mussai, Francis

“…Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several…”
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Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity by Fultang, Livingstone, Booth, Sarah, Yogev, Orli, Martins da Costa, Barbara, Tubb, Vanessa, Panetti, Silvia, Stavrou, Victoria, Scarpa, Ugo, Jankevics, Andris, Lloyd, Gavin, Southam, Andrew, Lee, Steven P., Dunn, Warwick B., Chesler, Louis, Mussai, Francis, De Santo, Carmela

“…Hematological and solid cancers catabolize the semiessential amino acid arginine to drive cell proliferation. However, the resulting low arginine…”
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Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A by Cerundolo, Vincenzo, De Santo, Carmela, Arscott, Ramon, Booth, Sarah, Karydis, Ioannis, Jones, Margaret, Asher, Ruth, Salio, Mariolina, Middleton, Mark

“…How neutrophils differentiate into anti-inflammatory or proinflammatory effector cells is unclear. Cerundolo and colleagues now show that systemic serum…”
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Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment by Mussai, Francis, De Santo, Carmela, Abu-Dayyeh, Issa, Booth, Sarah, Quek, Lynn, McEwen-Smith, Rosanna M., Qureshi, Amrana, Dazzi, Francesco, Vyas, Paresh, Cerundolo, Vincenzo

“…Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the second most common frequent leukemia of childhood. Patients may present with…”
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Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target by Mussai, Francis, Egan, Sharon, Higginbotham-Jones, Joseph, Perry, Tracey, Beggs, Andrew, Odintsova, Elena, Loke, Justin, Pratt, Guy, U, Kin Pong, Lo, Anthony, Ng, Margaret, Kearns, Pamela, Cheng, Paul, De Santo, Carmela

“…Acute myeloid leukemia (AML) is one of the most common acute leukemias in adults and children, yet significant numbers of patients relapse and die of disease…”
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Combination Lenalidomide and Azacitidine: A Novel Salvage Therapy in Patients Who Relapse After Allogeneic Stem-Cell Transplantation for Acute Myeloid Leukemia by Craddock, Charles, Slade, Daniel, De Santo, Carmela, Wheat, Rachel, Ferguson, Paul, Hodgkinson, Andrea, Brock, Kristian, Cavenagh, Jamie, Ingram, Wendy, Dennis, Mike, Malladi, Ram, Siddique, Shamyla, Mussai, Francis, Yap, Christina

“…Salvage options for patients who relapse after allogeneic stem-cell transplantation (allo-SCT) for acute myeloid leukemia (AML) and myelodysplasia (MDS) remain…”
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Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma by De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Alberto, Mussai, Francis

“…Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of…”
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Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells by Collins, Paul J., Fox, Christopher P., George, Lindsay, Pearce, Hayden, Ryan, Gordon, De Santo, Carmela, Mussai, Frances, Lewis, David, Long, Heather, Shannon-Lowe, Claire

“…Chronic active Epstein-Barr virus (CAEBV) typically presents as persistent infectious mononucleosis-like disease and/or hemophagocytic lymphohistocytosis…”
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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells by Gallina, Giovanna, Dolcetti, Luigi, Serafini, Paolo, De Santo, Carmela, Marigo, Ilaria, Colombo, Mario P, Basso, Giuseppe, Brombacher, Frank, Borrello, Ivan, Zanovello, Paola, Bicciato, Silvio, Bronte, Vincenzo

“…Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells…”
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Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies by Fultang, Livingstone, Gneo, Luciana, De Santo, Carmela, Mussai, Francis J.

“…Tumor cells require a higher supply of nutrients for growth and proliferation than normal cells. It is well established that metabolic reprograming in cancers…”
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PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults by Fenwick, Nicola, Weston, Rebekah, Wheatley, Keith, Hodgson, Jodie, Marshall, Lynley, Elliott, Martin, Makin, Guy, Ng, Antony, Brennan, Bernadette, Lowis, Stephen, Adamski, Jenny, Kilday, John Paul, Cox, Rachel, Gattens, Mike, Moore, Andrew, Trahair, Toby, Ronghe, Milind, Campbell, Martin, Campbell, Helen, Williams, Molly W, Kirby, Maria, Van Eijkelenburg, Natasha, Keely, Jennifer, Scarpa, Ugo, Stavrou, Victoria, Fultang, Livingstone, Booth, Sarah, Cheng, Paul, De Santo, Carmela, Mussai, Francis

“…The survival for many children with relapsed/refractory cancers remains poor despite advances in therapies. Arginine metabolism plays a key role in the…”
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Nitroaspirin Corrects Immune Dysfunction in Tumor-Bearing Hosts and Promotes Tumor Eradication by Cancer Vaccination by De Santo, Carmela, Serafini, Paolo, Marigo, Ilaria, Dolcetti, Luigi, Bolla, Manlio, Del Soldato, Piero, Melani, Cecilia, Guiducci, Cristiana, Colombo, Mario P., Iezzi, Manuela, Musiani, Piero, Zanovello, Paola, Bronte, Vincenzo, Ignarro, Louis J.

“…Active suppression of tumor-specific T lymphocytes can limit the immune-mediated destruction of cancer cells. Of the various strategies used by tumors to…”
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G‐CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment by Maneta, Ebtehag, Fultang, Livingstone, Taylor, Jemma, Pugh, Matthew, Jenkinson, William, Anderson, Graham, Coomarasamy, Arri, Kilby, Mark D, Lissauer, David M, Mussai, Francis, De Santo, Carmela

“…Objectives Recombinant granulocyte colony‐stimulating factor (G‐CSF) is frequently administered to patients with cancer to enhance granulocyte recovery…”
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Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy by Bokori-Brown, Monika, Metz, Jeremy, Petrov, Peter G, Mussai, Francis, De Santo, Carmela, Smart, Neil J, Saunders, Sarah, Knight, Bridget, Pastan, Ira, Titball, Richard W, Winlove, C Peter

“…Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of…”
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Derangement of immune responses by myeloid suppressor cells by SERAFINI, Paolo, DE SANTO, Carmela, MARIGO, Ilaria, CINGARLINI, Sara, DOLCETTI, Luigi, GALLINA, Giovanna, ZANOVELLO, Paola, BRONTE, Vincenzo

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer by Gneo, Luciana, Rizkalla, Nagy, Hejmadi, Rahul, Mussai, Francis, de Santo, Carmela, Middleton, Gary

“…Background Monocytic myeloid-derived suppressor cells (M-MDSCs) are significantly expanded in the blood of colorectal cancer (CRC) patients. However, their…”
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Targeting the arginine metabolic brake enhances immunotherapy for leukaemia by Mussai, Francis, Wheat, Rachel, Sarrou, Evgenia, Booth, Sarah, Stavrou, Victoria, Fultang, Livingstone, Perry, Tracey, Kearns, Pamela, Cheng, Paul, Keeshan, Karen, Craddock, Charles, De Santo, Carmela

“…Therapeutic approaches which aim to target Acute Myeloid Leukaemia through enhancement of patients’ immune responses have demonstrated limited efficacy to…”
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