Search Results - "de Síbio, Maria Teresa"
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Triiodothyronine modulates the expression of leptin and adiponectin in 3T3-L1 adipocytes
Published in Einstein (São Paulo, Brazil) (01-01-2015)“…To study the effect of different doses of triiodothyronine on gene expression of the adipokines leptin and adiponectin, at different times, and to evaluate the…”
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2
Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity
Published in TheScientificWorld (01-01-2012)“…Aims. To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals. Main…”
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3
Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism
Published in International journal of endocrinology (01-01-2019)“…A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals…”
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4
Estrogen-Responsive Genes Overlap with Triiodothyronine-Responsive Genes in a Breast Carcinoma Cell Line
Published in TheScientificWorld (01-01-2014)“…It has been well established that estrogen plays an important role in the progression and treatment of breast cancer. However, the role of triiodothyronine…”
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5
MODY calculator applied in patients with clinical diagnosis of type 1 diabetes mellitus: Is a higher cutoff needed?
Published in Heliyon (30-08-2024)“…This study aimed to evaluate the mean post-test probability (PTP) of the Maturity-onset diabetes of the young (MODY) calculator in a multiethnic cohort of…”
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6
Effects of Triiodothyronine on Human Osteoblast-Like Cells: Novel Insights From a Global Transcriptome Analysis
Published in Frontiers in cell and developmental biology (17-06-2022)“…Background: Thyroid hormones play a significant role in bone development and maintenance, with triiodothyronine (T3) particularly being an important modulator…”
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7
A comparative genotoxicity study of a supraphysiological dose of triiodothyronine (T₃) in obese rats subjected to either calorie-restricted diet or hyperthyroidism
Published in PloS one (28-02-2013)“…This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals…”
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8
Triiodothyronine increases mRNA and protein leptin levels in short time in 3T3-L1 adipocytes by PI3K pathway activation
Published in PloS one (18-09-2013)“…The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of leptin mRNA expression and…”
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9
Triiodothyronine and breast cancer
Published in World journal of clinical oncology (10-08-2014)“…The thyroid hormones (THs), triiodothyronine (T3) and thyroxine (T4), are essential for survival; they are involved in the processes of development, growth,…”
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10
Human breast tumor slices as an alternative approach to cell lines to individualize research for each patient
Published in European journal of cancer prevention (01-07-2012)“…There are several breast cancer experimental models including cell lines, which are commonly used due to ease of handling and storage. However, the continued…”
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11
Thyroid hormone status interferes with estrogen target gene expression in breast cancer samples of menopausal women
Published in The FASEB journal (01-04-2013)“…Abstract only We investigated thyroid hormone levels in menopausal BrC patients, and verified the action of triiodothyronine (T3) on genes regulated by…”
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12
Thyroid Hormone Status Interferes with Estrogen Target Gene Expression in Breast Cancer Samples in Menopausal Women
Published in ISRN endocrinology (2014)“…We investigated thyroid hormone levels in menopausal BrC patients and verified the action of triiodothyronine on genes regulated by estrogen and by…”
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13
Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine
Published in Biotechnology journal (01-05-2021)“…Background An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease…”
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14
Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture
Published in Molecular and cellular endocrinology (15-09-2020)“…Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2…”
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15
Pitfalls and challenges of the purinergic signaling cascade in obesity
Published in Biochemical pharmacology (01-12-2020)“…[Display omitted] Obesity is a worldwide health problem which have reached pandemic proportions, now also including low and middle-income countries. Excessive…”
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16
The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells
Published in Molecular and cellular endocrinology (15-04-2020)“…Triiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat production, and promote differentiation of white adipose tissue (WAT) into…”
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17
The importance of estrogen for bone protection in experimental hyperthyroidism in human osteoblasts
Published in Life sciences (1973) (15-08-2019)“…Triiodothyronine (T3) and estrogen (E2) play important roles in the bone remodeling process and signaling of receptor activator of the nuclear factor-kappa β…”
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Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3‐L1 Adipocytes
Published in Lipids (01-02-2019)“…Adipose tissue (AT), an endocrine organ that modulates several physiological functions by synthesizing and releasing adipokines such as adiponectin, is a…”
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19
Triiodothyronine activated extranuclear pathways upregulate adiponectin and leptin in murine adipocytes
Published in Molecular and cellular endocrinology (01-03-2020)“…Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that…”
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Triiodothyronine (T3) induces HIF1A and TGFA expression in MCF7 cells by activating PI3K
Published in Life sciences (1973) (01-06-2016)“…High expression levels of hypoxia inducing factor 1 alpha are related to mammary carcinogenesis. In previous studies, we demonstrated that expression of…”
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