Hexane extract from SpoSndias mombin L. (Anacardiaceae) prevents behavioral and oxidative status changes on model of Parkinson's disease in zebrafish

The search for new therapies, derived from natural compounds in order to prevent and treat Parkinson's disease (PD) has aroused the interest of many researchers. Spondias mombin (L) has active constituents with known antioxidant and anti-inflammatory activities. The aim of this study was to eva...

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Published in:	Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 241; p. 108953
Main Authors:	Santo, Glaucia Dal, de Veras, Bruno Oliveira, Rico, Eduardo, Magro, Jacir Dal, Agostini, Jotele Fontana, Vieira, Leucio Duarte, Calisto, Jean Felipe Fossá, Mocelin, Ricieri, de Sá Fonseca, Vitória, Wanderley, Almir Gonçalves
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2021
Subjects:	Antioxidant activity Parkinson Rotenone Spondias mombin Zebrafish Spondias mombin Zebrafish Antioxidant activity Parkinson Rotenone
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Summary:	The search for new therapies, derived from natural compounds in order to prevent and treat Parkinson's disease (PD) has aroused the interest of many researchers. Spondias mombin (L) has active constituents with known antioxidant and anti-inflammatory activities. The aim of this study was to evaluate the neuroprotective potential of the hexane extract of S. mombin (EHSm) in an experimental model of DP induced by rotenone in zebrafish. The analysis of GC/MS demonstrated cyclogallipharaol (13.88%) and dl-α-tocopherol (8.08%) mostly, while HPLC-DAD indicated the presence of quercetin (<5), quercetrin (6.54 mg/g) and rutin (8.83 mg/g). The zebrafish exposed for 4 weeks to rotenone (ROT, 3 μg/L) and EHSm (5, 15, 25 mg/L). EHSm (25 mg/L) was able to reverse the behavioral damage induced by ROT in the entries and time spent in the top area of the tank. The parameters biochemicals indicated of EHSm prevented oxidative stress (TBARS e total thiols), inflammation and dopamine uptake triggered by ROT, evidenced of increased on the CAT, SOD and GSH and decreased of GST, O2− production and NADPH oxidase activities. We conclude that EHSm demonstrate a neuroprotector effect mediated through anxiolytic and antioxidant activities. However, more studies are necessary to elucidate the exact mechanism underlying the effects of EHSm on DP induced by rotenone in zebrafish. [Display omitted] •EHSm was able to prevent changes caused by ROT in the levels of O2− and NADPH oxidase.•Treatment with EHSm changes in the animals' exploratory profile.•EHSm prevents changes caused by ROT in the Tbars and GSH levels.•EHSm prevents changes caused by ROT on the SOD, CAT, GST activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1532-0456 1878-1659
DOI:	10.1016/j.cbpc.2020.108953