Association of the HLA-B52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

Association of the HLA-B52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

Several human leukocyte antigen (HLA) class I alleles are associated with the susceptibility to human immunodeficiency virus-1 (HIV-1) infection and/or AIDS progression. Of these, the HLA-B alleles are considered the strongest genetic determinant of disease outcome. We evaluated the influence of the...

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Bibliographic Details
Published in:Genes and immunity Vol. 15; no. 4; pp. 256 - 262
Main Authors: Teixeira, S L M, de Sá, N B R, Campos, D P, Coelho, A B, Guimarães, M L, Leite, T C N F, Veloso, V G, Morgado, M G
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01-06-2014
Nature Publishing Group
Subjects:
631/208/2489/144
631/250/248
692/699/249/1570/1901
Acquired immune deficiency syndrome
Acquired Immunodeficiency Syndrome - genetics
Acquired Immunodeficiency Syndrome - immunology
Adolescent
Adult
AIDS
AIDS (Disease)
Alleles
Allelomorphism
Antigens
Biomedical and Life Sciences
Biomedicine
Brazil
Cancer Research
Development and progression
Ethnicity
Female
Gene Expression
Gene Frequency - immunology
Genes
Genetic aspects
Health aspects
Histocompatibility antigens
HIV
HIV infection
HIV-1 - immunology
HLA histocompatibility antigens
HLA-B52 Antigen - genetics
HLA-B52 Antigen - immunology
Human Genetics
Human immunodeficiency virus
Human immunodeficiency virus 1
Humans
Immunology
Infections
Leukocytes
Male
Middle Aged
original-article
Sociodemographics
Brazil
Rio de Janeiro Brazil
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Summary:Several human leukocyte antigen (HLA) class I alleles are associated with the susceptibility to human immunodeficiency virus-1 (HIV-1) infection and/or AIDS progression. Of these, the HLA-B alleles are considered the strongest genetic determinant of disease outcome. We evaluated the influence of the HLA-B alleles on AIDS progression among HIV-1-positive individuals from Rio de Janeiro, Brazil, who were categorized as rapid progressors (RPs), typical progressors (TPs) or long-term non-progressors (LTNPs). In this study, significant differences in HLA-B allele frequencies were observed among the three progression groups for the B*48, B*49 and B*52 alleles. After controlling for other factors associated with AIDS progression, the presence of the B*52 allele was shown to be a significant protective factor (hazard ratio (HR) 0.49 (95% confidence interval (CI) 0.27–0.90) P <0.03). Although no direct association was observed between the presence of the B*27 or B*57 allele and the LTNP profile compared with the TP or RP groups, the adjusted model confirmed that these alleles are protective factors against AIDS progression (HR 0.62 (95% CI 0.38–0.99) P <0.05), as previously described. These data corroborate the existence of significant differences in HLA-B allele frequencies among the distinct AIDS progression profiles and further elucidate the role of HLA alleles in the outcome of HIV infections in diverse populations.
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ISSN:1466-4879
1476-5470
DOI:10.1038/gene.2014.14