The prevalence of internuclear ophthalmoparesis in a population-based cohort of individuals with multiple sclerosis

The prevalence of internuclear ophthalmoparesis in a population-based cohort of individuals with multiple sclerosis

•Internuclear ophthalmoparesis (INO) is a common eye-moment disorder in MS.•INO can be reliably detected with infrared oculography eye-tracking methods.•INO is detected in 24% of individuals with multiple sclerosis.•INO is more prevalent among males with MS.•INO diagnosis is associated with worse co...

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Bibliographic Details
Published in:Multiple sclerosis and related disorders Vol. 63; p. 103824
Main Authors: Hof, S.N., Loonstra, F.C., de Ruiter, L.R.J., van Rijn, L.J., Petzold, A., Uitdehaag, B.M.J., Nij Bijvank, J.A.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-07-2022
Subjects:
Eye-Tracking technology
Internuclear ophthalmoparesis
Internuclear ophthalmoplegia
Multiple sclerosis
Ocular motility disorders
Oculography
Prevalence
Internuclear ophthalmoparesis
Internuclear ophthalmoplegia
Multiple sclerosis
Prevalence
Oculography
INO
Eye-Tracking technology
Ocular motility disorders
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Summary:•Internuclear ophthalmoparesis (INO) is a common eye-moment disorder in MS.•INO can be reliably detected with infrared oculography eye-tracking methods.•INO is detected in 24% of individuals with multiple sclerosis.•INO is more prevalent among males with MS.•INO diagnosis is associated with worse cognition, arm function and disability in MS. Internuclear ophthalmoparesis (INO) occurs in 15–52% of individuals with multiple sclerosis (MS) and is reliably detected by infrared oculography. Methods for diagnosing INO with infrared oculography and the association between INO and MS characteristics need confirmation. We aimed to describe INO prevalence and the clinical characteristics of individuals with MS and INO in a population-based cohort of individuals with MS born in the year 1966 (Project Y). Previously described thresholds for the versional dysconjugacy index (VDI), assessed with standardized infrared oculography, were used to detect INO in participants of project Y. Clinical characteristics, visual functioning and complaints were compared between individuals with MS with INO and individuals with MS without INO. Two-hundred-twenty individuals with MS and 110 healthy controls were included. VDI values exceeding the threshold for INO presented in 53 (24%) individuals with MS and 19 controls (13%). INO was associated with male sex, greater disability, worse cognition and worse arm function in individuals with MS. There was no association with disease duration, visual functioning or complaints. INO is prevalent among individuals with MS aged fifty-three and related to clinical characteristics of MS. INO was more frequently detected in healthy controls than previous studies, implying that oculography based diagnosis of INO requires further refinement.
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ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2022.103824