Search Results - "de Rosales, Rafael T. M"

Bisphosphonate-Anchored PEGylation and Radiolabeling of Superparamagnetic Iron Oxide: Long-Circulating Nanoparticles for in Vivo Multimodal (T1 MRI-SPECT) Imaging by Sandiford, Lydia, Phinikaridou, Alkystis, Protti, Andrea, Meszaros, Levente K, Cui, Xianjin, Yan, Yong, Frodsham, George, Williamson, Peter A, Gaddum, Nicholas, Botnar, René M, Blower, Philip J, Green, Mark A, de Rosales, Rafael T. M

“…The efficient delivery of nanomaterials to specific targets for in vivo biomedical imaging is hindered by rapid sequestration by the reticuloendothelial system…”
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Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging by Gawne, Peter J., Man, Francis, Blower, Philip J., T. M. de Rosales, Rafael

“…The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical application in a rational manner depends on reliable, clinically…”
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Imaging Nanomedicine-Based Drug Delivery: a Review of Clinical Studies by Man, Francis, Lammers, Twan, T. M. de Rosales, Rafael

“…Imaging plays a key role in the preclinical evaluation of nanomedicine-based drug delivery systems and it has provided important insights into their mechanism…”
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Harnessing Nanomedicine to Potentiate the Chemo-Immunotherapeutic Effects of Doxorubicin and Alendronate Co-Encapsulated in Pegylated Liposomes by Gabizon, Alberto, Shmeeda, Hilary, Draper, Benjamin, Parente-Pereira, Ana, Maher, John, Carrascal-Miniño, Amaia, de Rosales, Rafael T. M, La-Beck, Ninh M

“…Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death inducer, in pegylated (Stealth) liposomes, is well known to have major…”
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Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles by Abdollah, Maha R. A, Carter, Thomas J, Jones, Clare, Kalber, Tammy L, Rajkumar, Vineeth, Tolner, Berend, Gruettner, Cordula, Zaw-Thin, May, Baguña Torres, Julia, Ellis, Matthew, Robson, Mathew, Pedley, R. Barbara, Mulholland, Paul, T. M. de Rosales, Rafael, Chester, Kerry Ann

“…The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast…”
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Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation by Carter, Thomas J., Agliardi, Giulia, Lin, Fang‐Yu, Ellis, Matthew, Jones, Clare, Robson, Mathew, Richard‐Londt, Angela, Southern, Paul, Lythgoe, Mark, Zaw Thin, May, Ryzhov, Vyacheslav, Rosales, Rafael T. M., Gruettner, Cordula, Abdollah, Maha R. A., Pedley, R. Barbara, Pankhurst, Quentin A., Kalber, Tammy L., Brandner, Sebastian, Quezada, Sergio, Mulholland, Paul, Shevtsov, Maxim, Chester, Kerry

“…Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune…”
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Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain by Lim Kee Chang, William, Chan, Tiffany G., Raguseo, Federica, Mishra, Aishwarya, Chattenton, Dani, de Rosales, Rafael T. M., Long, Nicholas J., Morse, Sophie V.

“…Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics and imaging agents across the blood–brain barrier. Uniform treatment…”
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Microwave-assisted synthesis of [52Mn]Mn-porphyrins: Applications in cell and liposome radiolabelling by Gawne, Peter J., Pinto, Sara M.A., Nielsen, Karin M., Keeling, George P., Pereira, Mariette M., T. M. de Rosales, Rafael

“…Manganese porphyrins have several therapeutic/imaging applications, including their use as radioprotectants (in clinical trials) and as paramagnetic MRI…”
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Liposome delivery to the brain with rapid short-pulses of focused ultrasound and microbubbles by Morse, Sophie V., Mishra, Aishwarya, Chan, Tiffany G., T. M. de Rosales, Rafael, Choi, James J.

“…Liposomes are clinically used drug carriers designed to improve the delivery of drugs to specific tissues while minimising systemic distribution. However,…”
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NHS-Functionalized THP Derivative for Efficient Synthesis of Kit-Based Precursors for 68Ga Labeled PET Probes by Floresta, Giuseppe, Keeling, George P., Memdouh, Siham, Meszaros, Levente K., de Rosales, Rafael T. M., Abbate, Vincenzo

“…Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low iron concentrations and their high affinities for oxophilic trivalent metal ions…”
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Nanoparticles Accumulate in the Female Reproductive System during Ovulation Affecting Cancer Treatment and Fertility by Poley, Maria, Mora-Raimundo, Patricia, Shammai, Yael, Kaduri, Maya, Koren, Lilach, Adir, Omer, Shklover, Jeny, Shainsky-Roitman, Janna, Ramishetti, Srinivas, Man, Francis, de Rosales, Rafael T. M, Zinger, Assaf, Peer, Dan, Ben-Aharon, Irit, Schroeder, Avi

“…Throughout the female menstrual cycle, physiological changes occur that affect the biodistribution of nanoparticles within the reproductive system. We…”
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Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines by Edmonds, Scott, Volpe, Alessia, Shmeeda, Hilary, Parente-Pereira, Ana C, Radia, Riya, Baguña-Torres, Julia, Szanda, Istvan, Severin, Gregory W, Livieratos, Lefteris, Blower, Philip J, Maher, John, Fruhwirth, Gilbert O, Gabizon, Alberto, T. M. de Rosales, Rafael

“…The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body…”
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Manganese-52: applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore by Gawne, Peter, Man, Francis, Fonslet, Jesper, Radia, Riya, Bordoloi, Jayanta, Cleveland, Matthew, Jimenez-Royo, Pilar, Gabizon, Alberto, Blower, Philip J, Long, Nicholas, de Rosales, Rafael T M

“…The ionophore 8-hydroxyquinoline (oxine) has been used to radiolabel cells and liposomal medicines with 111In and, more recently, 89Zr, for medical nuclear…”
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68Ga-bisphosphonates for the imaging of extraosseous calcification by positron emission tomography by Keeling, George P., Baark, Friedrich, Katsamenis, Orestis L., Xue, Jing, Blower, Philip J., Bertazzo, Sergio, T. M. de Rosales, Rafael

“…Radiolabelled bisphosphonates (BPs) and [ 18 F]NaF ( 18 F-fluoride) are the two types of radiotracers available to image calcium mineral (e.g. bone), yet only…”
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PET Imaging of Small Extracellular Vesicles via [89Zr]Zr(oxinate)4 Direct Radiolabeling by Khan, Azalea A, Man, Francis, Faruqu, Farid N, Kim, Jana, Al-Salemee, Fahad, Carrascal-Miniño, Amaia, Volpe, Alessia, Liam-Or, Revadee, Simpson, Paul, Fruhwirth, Gilbert O, Al-Jamal, Khuloud T, T. M. de Rosales, Rafael

“…Exosomes or small extracellular vesicles (sEVs) are increasingly gaining attention for their potential as drug delivery systems and biomarkers of disease…”
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On the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study by Lacerda, Sara, Zhang, Wuyuan, T. M. de Rosales, Rafael, Da Silva, Isidro, Sobilo, Julien, Lerondel, Stéphanie, Tóth, Éva, Djanashvili, Kristina

“…Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and…”
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[68Ga]Ga-THP-Pam: A Bisphosphonate PET Tracer with Facile Radiolabeling and Broad Calcium Mineral Affinity by Keeling, George P, Sherin, Billie, Kim, Jana, San Juan, Belinda, Grus, Tilmann, Eykyn, Thomas R, Rösch, Frank, Smith, Gareth E, Blower, Philip J, Terry, Samantha Y. A, T. M. de Rosales, Rafael

“…Calcium minerals such as hydroxyapatite (HAp) can be detected noninvasively in vivo using nuclear imaging agents such as [18F]­NaF (available from cyclotrons),…”
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Mechanisms of inclusion of thallium-201 into Prussian blue nanoparticles for nuclear medicine applications by Wulfmeier, Katarzyna M, Blower, Philip J, Fajardo, Galo Paez, Huband, Steven, de Rosales, Rafael T M, Walker, David, Terry, Samantha Ya, Abbate, Vincenzo, Pellico, Juan

“…Prussian blue is known for its high affinity for thallium and other univalent metal cations and has been used as a treatment for radiocaesium and…”
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[Ga]Ga-THP-tetrazine for bioorthogonal click radiolabelling: pretargeted PET imaging of liposomal nanomedicines by Mishra, Aishwarya, Carrascal-Miniño, Amaia, Kim, Jana, de Rosales, Rafael

“…Pretargeted PET imaging using bioorthogonal chemistry is a leading strategy for the tracking of long-circulating agents such as antibodies and…”
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Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents by Wang, Julie Tzu-Wen, Cabana, Laura, Bourgognon, Maxime, Kafa, Houmam, Protti, Andrea, Venner, Kerrie, Shah, Ajay M., Sosabowski, Jane K., Mather, Stephen J., Roig, Anna, Ke, Xiaoxing, Van Tendeloo, Gustaaf, de Rosales, Rafael T. M., Tobias, Gerard, Al-Jamal, Khuloud T.

“…Carbon nanotubes (CNTs) are one of the most promising nanomaterials to be used in biomedicine for drug/gene delivery as well as biomedical imaging. This study…”
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