Exploring the Antioxidant Potential of ITalisia esculenta/I Using In Vitro and In Vivo Approaches

Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was investigated using biochemical and 3T3 cell line assays as w...

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Bibliographic Details
Published in:	Nutrients Vol. 15; no. 17
Main Authors:	da Silva Cordeiro, Maria Lúcia, de Queiroz Aquino-Ma, da Silva, Ariana Pereira, Naliato, Georggia Fatima Silva, Silveira, Elielson Rodrigo, Theodoro, Raquel Cordeiro, da Santos, Deborah Yara Alves Cursino, Rocha, Hugo Alexandre Oliveira, Scortecci, Katia Castanho
Format:	Journal Article
Language:	English
Published:	MDPI AG 01-09-2023
Subjects:	Antioxidants Ethylenediaminetetraacetic acid Vincristine Brazil California
Online Access:	Get full text
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Summary:	Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are used in the treatment and prevention of many diseases. The antioxidant potential of T. esculenta extracts obtained from leaves and fruit peels was investigated using biochemical and 3T3 cell line assays as well as in vivo assays using an organism model Tenebrio molitor. Four extracts were tested: hydroethanolic extracts from leaves (HF) and from fruit peels (HC), and infusion extracts from leaves (IF) and from fruit peels (IC). The biochemical assays demonstrated an antioxidant capacity verified by TAC, reducing power, DPPH, and copper chelating assays. None of the extracts exhibited cytotoxicity against 3T3 cells, instead offering a protection against CuSO[sub.4]-induced oxidative stress. The antioxidant activity observed in the extracts, including their role as free radical scavengers, copper chelators, and stress protectors, was further confirmed by T. molitor assays. The CLAE-DAD analysis detected phenolic compounds, including gallic acid, rutin, and quercitrin, as the main constituents of the samples. This study highlights that leaf and fruit peels extracts of T. esculenta could be effective protectors against ROS and copper-induced stress in cellular and invertebrate models, and they should be considered as coadjutants in the treatment and prevention of diseases related to oxidative stress and for the development of natural nutraceutical products.
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu15173855