Role of UCP2 polymorphisms on dietary intake of obese patients who underwent bariatric surgery

Summary Uncoupling protein 2 ( UCP2 ) plays an important role in body weight and energy metabolism and may be related to the control of food consumption. This study aimed to investigate the contribution of UCP2 gene variants on the dietary intake on a population after bariatric surgery. This study e...

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Published in:	Clinical obesity Vol. 6; no. 5; pp. 354 - 358
Main Authors:	Nicoletti, C. F., Kimura, B. M., de Oliveira, B. A. P., de Pinhel, M. A. S., Salgado, W., Marchini, J. S., Nonino, C. B.
Format:	Journal Article
Language:	English
Published:	Chichester, UK Blackwell Publishing Ltd 01-10-2016 Wiley Subscription Services, Inc
Subjects:	Adult Alleles Appetite Regulation Bariatric Surgery Body Mass Index Brazil Combined Modality Therapy Diet, Reducing dietary intake Female Gastrointestinal surgery Gene Frequency Genes Genetic Association Studies Humans Longitudinal Studies Male Obesity, Morbid - diet therapy Obesity, Morbid - metabolism Obesity, Morbid - surgery Patient Compliance polymorphism Polymorphism, Single Nucleotide Postoperative period Promoter Regions, Genetic Retrospective Studies Satiety Response uncoupling protein 2 Uncoupling Protein 2 - genetics Uncoupling Protein 2 - metabolism Weight Loss uncoupling protein 2 polymorphism dietary intake Bariatric surgery
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Summary:	Summary Uncoupling protein 2 ( UCP2 ) plays an important role in body weight and energy metabolism and may be related to the control of food consumption. This study aimed to investigate the contribution of UCP2 gene variants on the dietary intake on a population after bariatric surgery. This study enrolled 150 obese patients (body mass index ≥ 35kg m−2) who submitted to Roux‐en‐Y gastric bypass. Weight (kg), BMI (kg m−2), energy (kcal d−1) and macronutrients intake (g d−1) of preoperative and 1‐year postoperative period were collected from medical records. Ala55Val and −866G>A polymorphisms in the UCP2 gene were genotyped through allelic discrimination method in real‐time polymerase chain reaction using the TaqMan pre‐designed SNP Genotyping Assays kits. Hardy–Weinberg equilibrium, t‐test and regression models were performed in statistical analysis (P<0.05).We found an allelic frequency of 0.44 for allele Val and 0.41 for allele A. In the postoperative period, patients with at least one rare allele for polymorphisms and with at least one rare allele for both polymorphisms together (haplotype) present a greater energy and carbohydrate intake, even after adjusting for gender, age and weight. Genetic variants in UCP2 gene were associated with the dietary consumption after Roux–En‐Y gastric bypass.
Bibliography:	ArticleID:COB12148 ark:/67375/WNG-GK9417PB-T istex:CAC7AC2F15BFA55778A533F23B07E03012D8F7E2 National Council of Scientific and Technological Development (CNPq) São Paulo Research Foundation (FAPESP) - No. #2012/03623-6; No. #2012/05539-2 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1758-8103 1758-8111
DOI:	10.1111/cob.12148