Search Results - "de Paz, José L."

GAG Multivalent Systems to Interact with Langerin by Rojo, Javier, Nieto, Pedro M, de Paz, José L

“…Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a pivotal role protecting organisms against pathogen infections. To…”
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Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine by Solera, Cristina, Macchione, Giuseppe, Maza, Susana, Kayser, M. Mar, Corzana, Francisco, de Paz, José L., Nieto, Pedro M.

“…The biological activity of midkine, a cytokine implicated in neuro‐ and tumourigenesis, is regulated by its binding to glycosaminoglycans (GAGs), such as…”
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Langerin–Heparin Interaction: Two Binding Sites for Small and Large Ligands As Revealed by a Combination of NMR Spectroscopy and Cross-Linking Mapping Experiments by Muñoz-García, Juan C, Chabrol, Eric, Vivès, Romain R, Thomas, Aline, de Paz, José L, Rojo, Javier, Imberty, Anne, Fieschi, Franck, Nieto, Pedro M, Angulo, Jesús

“…Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent…”
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Glycodendrimers as Chondroitin Sulfate Mimetics: Synthesis and Binding to Growth Factor Midkine by Domínguez‐Rodríguez, Pedro, Reina, José J., Gil‐Caballero, Sergio, Nieto, Pedro M., de Paz, José L., Rojo, Javier

“…Chondroitin sulfate (CS) is a member of the glycosaminoglycan (GAG) family, a class of polysaccharides implicated in relevant biological functions. The…”
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Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery by Marques, Joana, PhD, Valle-Delgado, Juan José, PhD, Urbán, Patricia, PhD, Baró, Elisabet, MSc, Prohens, Rafel, PhD, Mayor, Alfredo, PhD, Cisteró, Pau, BSc, Delves, Michael, PhD, Sinden, Robert E., DSc, FMedSci, Grandfils, Christian, PhD, de Paz, José L., PhD, García-Salcedo, José A., PhD, Fernàndez-Busquets, Xavier, PhD

“…Abstract The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy…”
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Second-Generation Dendrimers with Chondroitin Sulfate Type‑E Disaccharides as Multivalent Ligands for Langerin by Domínguez-Rodríguez, Pedro, Vivès, Corinne, Thepaut, Michel, Fieschi, Franck, Nieto, Pedro M, de Paz, José L, Rojo, Javier

“…Chondroitin sulfate type-E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as modulation of the neuronal growth…”
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Fluorous-tag assisted synthesis of a glycosaminoglycan mimetic tetrasaccharide as a high-affinity FGF-2 and midkine ligand by Maza, Susana, Gandia-Aguado, Noel, de Paz, José L., Nieto, Pedro M.

“…[Display omitted] Here, we present the preparation of a sulfated, fully protected tetrasaccharide derivative following the glycosaminoglycan (GAG)-related…”
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The Interaction between Chondroitin Sulfate and Dermatan Sulfate Tetrasaccharides and Pleiotrophin by García-Jiménez, María Jose, Torres-Rico, Myriam, de Paz, José L, Nieto, Pedro M

“…Pleiotrophin (PTN) is a neurotrophic factor that participates in the development of the embryonic central nervous system (CNS) and neural stem cell regulation…”
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Synthesis of a Fluorous-Tagged Hexasaccharide and Interaction with Growth Factors Using Sugar-Coated Microplates by Maza, Susana, de Paz, José L, Nieto, Pedro M

“…Here, we report the synthesis of a sulfated, fully protected hexasaccharide as a glycosaminoglycan mimetic and the study of its interactions with different…”
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Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides by Mena-Barragán, Teresa, de Paz, José L, Nieto, Pedro M

“…Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. Following this approach, a CS…”
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The affinity of the FimH fimbrial adhesin is receptor‐driven and quasi‐independent of Escherichia coli pathotypes by Bouckaert, Julie, Mackenzie, Jenny, De Paz, José L., Chipwaza, Beatrice, Choudhury, Devapriya, Zavialov, Anton, Mannerstedt, Karin, Anderson, Jennifer, Piérard, Denis, Wyns, Lode, Seeberger, Peter H., Oscarson, Stefan, De Greve, Henri, Knight, Stefan D.

“…Summary Type‐1 fimbriae are important virulence factors for the establishment of Escherichia coli urinary tract infections. Bacterial adhesion to the…”
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Effect of the Substituents of the Neighboring Ring in the Conformational Equilibrium of Iduronate in Heparin-like Trisaccharides by Muñoz-García, Juan Carlos, López-Prados, Javier, Angulo, Jesús, Díaz-Contreras, Irene, Reichardt, Niels, de Paz, José L., Martín-Lomas, Manuel, Nieto, Pedro M.

“…Based on the structure of the regular heparin, we have prepared a smart library of heparin‐like trisaccharides by incorporating some sulfate groups in the…”
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Synthesis of Chondroitin Sulfate Oligosaccharides Using N-(Tetrachlorophthaloyl)- and N-(Trifluoroacetyl)galactosamine Building Blocks by Macchione, Giuseppe, Maza, Susana, Mar Kayser, M., de Paz, José L., Nieto, Pedro M.

“…We have explored synthetic routes for the preparation of chondroitin sulfate (CS) oligosaccharides based on the use of N‐tetrachlorophthaloyl‐ (N‐TCP) and…”
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Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach by Macchione, Giuseppe, de Paz, José L., Nieto, Pedro M.

“…•We describe the synthesis of hyaluronic acid oligosaccharides.•Glucuronic acid units were employed in the glycosylation reactions.•A three-step deprotection…”
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Insights into the Glycosaminoglycan-Mediated Cytotoxic Mechanism of Eosinophil Cationic Protein Revealed by NMR by García-Mayoral, M. Flor, Canales, Ángeles, Díaz, Dolores, López-Prados, Javier, Moussaoui, Mohammed, de Paz, José L, Angulo, Jesús, Nieto, Pedro M, Jiménez-Barbero, Jesús, Boix, Ester, Bruix, Marta

“…Protein-glycosaminoglycan interactions are essential in many biological processes and human diseases, yet how their recognition occurs is poorly understood…”
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Synthesis, structure and midkine binding of chondroitin sulfate oligosaccharide analogues by Torres-Rico, Myriam, Maza, Susana, de Paz, José L, Nieto, Pedro M

“…The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because…”
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Synthesis and interaction with growth factors of sulfated oligosaccharides containing an anomeric fluorinated tail by de Paz, José L., García-Jiménez, María José, Jafari, Vahid, García-Domínguez, Mario, Nieto, Pedro M.

“…[Display omitted] •Sulfated oligosaccharides were synthesized as glycosaminoglycan (GAG) mimetics.•The synthesis was facilitated by the presence of a…”
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Midkine Interaction with Chondroitin Sulfate Model Synthetic Tetrasaccharides and Their Mimetics: The Role of Aromatic Interactions by García‐Jiménez, María José, Gil‐Caballero, Sergio, Maza, Susana, Corzana, Francisco, Juárez‐Vicente, Francisco, Miles, Jonathan R., Sakamoto, Kazuma, Kadomatsu, Kenji, García‐Domínguez, Mario, Paz, José L., Nieto, Pedro M.

“…Midkine (MK) is a neurotrophic factor that participates in the embryonic central nervous system (CNS) development and neural stem cell regulation, interacting…”
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Interactions between a Heparin Trisaccharide Library and FGF-1 Analyzed by NMR Methods by García-Jiménez, María José, Gil-Caballero, Sergio, Canales, Ángeles, Jiménez-Barbero, Jesús, de Paz, José L, Nieto, Pedro M

“…FGF-1 is a potent mitogen that, by interacting simultaneously with Heparan Sulfate Glycosaminoglycan HSGAG and the extracellular domains of its membrane…”
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Synthesis of chondroitin/dermatan sulfate-like oligosaccharides and evaluation of their protein affinity by fluorescence polarization by Maza, Susana, Mar Kayser, M, Macchione, Giuseppe, López-Prados, Javier, Angulo, Jesús, de Paz, José L, Nieto, Pedro M

“…Here, we present a novel approach for the chemical synthesis of chondroitin and dermatan sulfate oligosaccharides. A key point of this strategy is the…”
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