Factors associated with potentially inappropriate medications in elderly with multiple myeloma

Introduction Elderly with cancer often have multimorbidity, which determines a higher risk of polypharmacy. This is related to negative clinical results such as adverse drug reaction and emergence service visits. Furthermore, polypharmacy increases the risk of using potentially inappropriate medicat...

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Bibliographic Details
Published in:	Journal of oncology pharmacy practice Vol. 30; no. 5; pp. 873 - 879
Main Authors:	Machado, Taisa R L, de Pádua, Cristiane A M, de Miranda Drummond, Paula L, Silveira, Lívia P, Malta, Jéssica S, dos Santos, Roberta M M, Costa, Naiane L, Reis, Adriano M M
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-08-2024 Sage Publications Ltd
Subjects:	Aged Aged, 80 and over Benzodiazepines Brazil - epidemiology Cardiovascular diseases Comorbidity Cross-Sectional Studies Female Hematology Humans Inappropriate Prescribing - statistics & numerical data Kidney diseases Male Middle Aged Multimorbidity Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - epidemiology Multivariate analysis Older people Polypharmacy Potentially Inappropriate Medication List Proton pump inhibitors Risk Factors Brazil aged potentially inappropriate medications elderly polypharmacy Multiple myeloma
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Summary:	Introduction Elderly with cancer often have multimorbidity, which determines a higher risk of polypharmacy. This is related to negative clinical results such as adverse drug reaction and emergence service visits. Furthermore, polypharmacy increases the risk of using potentially inappropriate medications. Objective To evaluate the use of potentially inappropriate medication in elderly with multiple myeloma and associated factors. Methods The study was conducted with older adults with multiple myeloma treated at outpatient oncology and hematology services in a southeastern Brazilian capital. Potentially inappropriate medications were classified using the American Geriatric Society/Beers 2019 Criteria. Variables were described using frequency and proportions, performing multiple logistic regression to identify factors associated with the use of potentially inappropriate medications. Results One hundred fifty-three older adults with multiple myeloma were included, with a median age of 70.9 years. The median number of medications was 8, and 63% of patients used polypharmacy. More than half (54%) of the patients used potentially inappropriate medications, and proton pump inhibitors (46%) and benzodiazepines (8%) were the most employed therapeutic classes. Older adults who used potentially inappropriate medications differed from those who did not use them in the following characteristics: income up to three minimum wages, higher schooling level, private service, multimorbidity, hypertension, cardiovascular disease, chronic kidney disease, depression, adverse event, and polypharmacy. Higher schooling levels and polypharmacy were independently associated with the use of potentially inappropriate medications in the multivariate analysis. Conclusion Potentially inappropriate medication use was high in patients with multiple myeloma studied. The use of polypharmacy and higher schooling levels were independently and positively associated with the use of potentially inappropriate medications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1078-1552 1477-092X 1477-092X
DOI:	10.1177/10781552231190009