Spatial cognitive deficits in an animal model of Wernicke–Korsakoff syndrome are related to changes in thalamic VDAC protein concentrations

Highlights • TD affects spatial learning and increased and decreased thalamic protein levels. • Four thalamic protein changes are related to spatial cognitive performance of rats. • Changes in VDAC, one of the four proteins, relate to rats’ spatial learning. • The association of VDAC is evident in t...

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Published in:	Neuroscience Vol. 294; pp. 29 - 37
Main Authors:	Bueno, K.O, de Souza Resende, L, Ribeiro, A.F, dos Santos, D.M, Gonçalves, E.C, Vigil, F.A.B, de Oliveira Silva, I.F, Ferreira, L.F, de Castro Pimenta, A.M, Ribeiro, A.M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 21-05-2015
Subjects:	Animals Cognition Disorders - metabolism Disease Models, Animal Korsakoff Syndrome - genetics Korsakoff Syndrome - metabolism Learning - physiology Male Neurology proteomic Proteomics - methods rats Rats, Wistar Space Perception spatial learning thalamus Thalamus - metabolism thiamine deficiency Thiamine Deficiency - genetics VDAC Voltage-Dependent Anion Channels - metabolism IPG PTD internal medullary lamina WE immobilized pH gradient Wernicke–Korsakoff syndrome rats Voltage-Dependent Anion Channels polymerase chain reaction pyrithiamine-induced TD thalamus Wernicke’s Encephalopathy MWM 2D SDS–PAGE IML thiamine deficiency proteomic spatial learning TD two-dimensional sodium dodecyl sulfate–polyacrylamide gel electrophoresis VDACs VDAC ATN anterior thalamic nuclei Morris Water Maze PCR WKS
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Summary:	Highlights • TD affects spatial learning and increased and decreased thalamic protein levels. • Four thalamic protein changes are related to spatial cognitive performance of rats. • Changes in VDAC, one of the four proteins, relate to rats’ spatial learning. • The association of VDAC is evident in the session with the worst performance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.03.001