Search Results - "de Oliveira Rezende Júnior, Celso"

Synthetic Studies toward the Total Synthesis of Tautomycetin by Pereira de Sant’Ana, Danilo, de Oliveira Rezende Júnior, Celso, Campagne, Jean-Marc, Dias, Luiz Carlos, Marcia de Figueiredo, Renata

“…The studies culminating in the synthesis of two large subunits of tautomycetin are described. The first one, fragment C1–C12 that has an anti-1,3-dimethyl…”
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A Novel Compound from the Phenylsulfonylpiperazine Class: Evaluation of In Vitro Activity on Luminal Breast Cancer Cells by da Silva, Fernanda Cardoso, Martinho, Ana Clara Cassiano, Ferreira, Helen Soares Valença, Siqueira, Raoni Pais, Arruda, Vinicius Marques, Guerra, Joyce Ferreira da Costa, de Souza, Maria Laura Dos Reis, Landin, Emanuelly Silva, Rezende Júnior, Celso de Oliveira, de Araújo, Thaise Gonçalves

“…Breast cancer (BC) is the most common cancer in women, and is characterized by its histological and molecular heterogeneity. Luminal BC is an estrogen…”
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Structure‐Metabolism Relationships of Benzimidazole Derivatives with anti‐Trypanosoma cruzi Activity for Chagas Disease by Espinoza‐Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso, Laureano de Souza, Mariana, Consolin Chelucci, Rafael, Michelan‐Duarte, Simone, Krogh, Renata, Gomes Ferreira, Leonardo Luiz, Valli, Marilia, Sena de Oliveira, Aldo, Andricopulo, Adriano D., Carlos Dias, Luiz

“…This study introduces further insights from the hit‐to‐lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the…”
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New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni by Silva, Raphael Tristão Cruvinel, Guidotti-Takeuchi, Micaela, Peixoto, Jéssica Laura Miranda, Demarqui, Fernanda Manaia, Mori, Ananda Paula, Dumont, Carolyne Ferreira, Ferreira, Gabriella Rayane Aparecida, Pereira, Gabriele de Menezes, Rossi, Daise Aparecida, Corbi, Pedro Paulo, Pavan, Fernando Rogério, Rezende Júnior, Celso de Oliveira, Melo, Roberta Torres de, Guerra, Wendell

“…This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] , [Pd(meg)(PPh )…”
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Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum by Lapierre, Thibault Joseph William Jacques Dit, Farago, Danilo Nascimento, de Moura Lodi Cruz, Mariza Gabriela Faleiro, de Melo Resende, Daniela, de Oliveira, Adriane Cristina Rosa, Dos Santos, Brenda Rosa Macedo, de Oliveira Souza, Felipe, Michelan-Duarte, Simone, Chelucci, Rafael C, Andricopulo, Adriano D, Ferreira, Leonardo L G, Pilau, Eduardo Jorge, Murta, Silvane Maria Fonseca, de Oliveira Rezende Júnior, Celso

“…An early exploration of the benzothiazole class against two kinetoplastid parasites, Leishmania infantum and Trypanosoma cruzi, has been performed after the…”
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Synthesis, Design, and Structure‐Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi by Cassiano Martinho, Ana Clara, Melo Resende, Daniela, Landin, Emanuelly Silva, Dit Lapierre, Thibault Joseph William Jacques, Bernardes, Talita Cristina Diniz, Martins, Luan Carvalho, Ferreira, Rafaela Salgado, Murta, Silvane Maria Fonseca, Oliveira Rezende Júnior, Celso

“…Chagas disease is a neglected tropical disease, endemic in Latin America and caused by the protozoan parasite Trypanosoma cruzi. Available treatments show low…”
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Quinic acid derivatives inhibit dengue virus replication in vitro by Zanello, Paula Rodrigues, Koishi, Andrea Cristine, Rezende Júnior, Celso de Oliveira, Oliveira, Larissa Albuquerque, Pereira, Adriane Antonia, de Almeida, Mauro Vieira, Duarte dos Santos, Claudia Nunes, Bordignon, Juliano

“…Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases…”
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Structure-based discovery of thiosemicarbazones as SARS-CoV-2 main protease inhibitors by Maltarollo, Vinícius Gonçalves, da Silva, Elany Barbosa, Kronenberger, Thales, Sena Andrade, Marina Mol, de Lima Marques, Gabriel V, Cândido Oliveira, Nereu J, Santos, Lucianna H, Oliveira Rezende Júnior, Celso de, Cassiano Martinho, Ana C, Skinner, Danielle, Fajtová, Pavla, M Fernandes, Thaís H, Silveira Dos Santos, Eduardo da, Rodrigues Gazolla, Poliana A, Martins de Souza, Ana P, da Silva, Milene Lopes, Dos Santos, Fabíola S, Lavorato, Stefânia N, Oliveira Bretas, Ana C, Carvalho, Diogo Teixeira, Franco, Lucas Lopardi, Luedtke, Stephanie, Giardini, Miriam A, Poso, Antti, Dias, Luiz C, Podust, Larissa M, Alves, Ricardo J, McKerrow, James, Andrade, Saulo F, Teixeira, Róbson R, Siqueira-Neto, Jair L, O'Donoghue, Anthony, de Oliveira, Renata B, Ferreira, Rafaela S

“…Discovery of novel SARS-CoV-2 main protease (M ) inhibitors using a structure-based drug discovery strategy. Virtual screening employing covalent and…”
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Hit-to-lead optimization of a pyrazinylpiperazine series against Leishmania infantum and Leishmania braziliensis by Jacques Dit Lapierre, Thibault Joseph William, Cruz, Mariza Gabriela Faleiro de Moura Lodi, Brito, Nícolas Peterson Ferreira, Resende, Daniela de Melo, Souza, Felipe de Oliveira, Pilau, Eduardo Jorge, da Silva, Meryck Felipe Brito, Neves, Bruno Junior, Murta, Silvane Maria Fonseca, Rezende Júnior, Celso de Oliveira

“…An early hit-to-lead optimization of a novel pyrazinylpiperazine series against L. infantum and L. braziliensis has been performed after an extensive SAR…”
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Optimization of benzenesulfonyl derivatives as anti-Trypanosomatidae agents: Structural design, synthesis, and pharmacological assessment against Trypanosoma cruzi and Leishmania infantum by Freitas de Lima Hercos, Guilherme, Gabriela Faleiro de Moura Lodi Cruz, Mariza, Clara Cassiano Martinho, Ana, de Melo Resende, Daniela, Farago Nascimento, Danilo, Derksen Macruz, Paula, Jorge Pilau, Eduardo, Maria Fonseca Murta, Silvane, de Oliveira Rezende Júnior, Celso

“…[Display omitted] Leishmaniasis and Chagas disease are neglected tropical diseases caused by Trypanosomatidae parasites. Given the numerous limitations…”
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Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents by da Silva Oliveira, Douglas Davison, Paz, Franciarli, Brito, Nícolas Peterson Ferreira, Krüger, Arne, Martinho, Ana Clara Cassiano, Lapierre, Thibault Joseph William Jacques Dit, de Oliveira Souza, Felipe, Maltarollo, Vinícius G., Kronenberger, Thales, Mendes, Marina Sena, Nonato, Maria Cristina, Pilau, Eduardo Jorge, Wrenger, Carsten, Wunderlich, Gerhard, Rezende Júnior, Celso de Oliveira

“…An optimization of the pyridylpiperazine series against Plasmodium falciparum has been performed, exploring a structure-activity relationship carried out on…”
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2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling by Ferreira, Rafael Augusto Alves, Junior, Celso de Oliveira Rezende, Martinez, Pablo David Grigol, Koovits, Paul John, Soares, Bruna Miranda, Ferreira, Leonardo L G, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D, Galuppo, Mariana K, Uliana, Silvia R B, Matheeussen, An, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz Carlos

“…Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this…”
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Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors by Medeiros, Alex R, Ferreira, Leonardo L G, de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Espinoza-Chávez, Rocío Marisol, Dias, Luiz Carlos, Andricopulo, Adriano D

“…Natural products based on imidazole scaffolds have inspired the discovery of a wide variety of bioactive compounds. Herein, a series of imidazoles that act as…”
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Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach by de Souza, Mariana L, de Oliveira Rezende Junior, Celso, Ferreira, Rafaela S, Espinoza Chávez, Rocio Marisol, Ferreira, Leonardo L. G, Slafer, Brian W, Magalhães, Luma G, Krogh, Renata, Oliva, Glaucius, Cruz, Fabio Cardoso, Dias, Luiz Carlos, Andricopulo, Adriano D

“…A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor…”
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Crystal structure and in vitro biological studies of a Pt(II) complex based on gallic acid and triphenylphosphine by Tristão Cruvinel Silva, Raphael, Pereira Silva-Caldeira, Priscila, Manaia Demarqui, Fernanda, Duque Lopes, Carla, de Albuquerque, Sérgio, Rogério Pavan, Fernando, Cristina Pereira-Maia, Elene, Diniz, Renata, de Oliveira, Alberto, de Oliveira Rezende Júnior, Celso, Guerra, Wendell

“…[Display omitted] •A novel Pt(II) complex based on gallic acid was synthesized.•The crystal structure of the Pt(II) complex was elucidated.•The complex…”
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Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease by de Oliveira Rezende Júnior, Celso, Martinez, Pablo David Grigol, Ferreira, Rafael Augusto Alves, Koovits, Paul John, Miranda Soares, Bruna, Ferreira, Leonardo L.G., Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D., Matheeussen, An, Van Pelt, Natascha, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz Carlos

“…Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. Because current treatments present several limitations, including long duration,…”
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New Palladium Complexes Containing Methyl Gallate and Octyl Gallate: Effect against IMycobacterium tuberculosis/I and ICampylobacter jejuni/I by Silva, Raphael Tristão Cruvinel, Guidotti-Takeuchi, Micaela, Peixoto, Jéssica Laura Miranda, Demarqui, Fernanda Manaia, Mori, Ananda Paula, Dumont, Carolyne Ferreira, Ferreira, Gabriella Rayane Aparecida, Pereira, Gabriele de Menezes, Rossi, Daise Aparecida, Corbi, Pedro Paulo, Pavan, Fernando Rogério, Rezende Júnior, Celso de Oliveira, Melo, Roberta Torres de, Guerra, Wendell

“…This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1,…”
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Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus by Flávia Clemente Dias, Renieidy, Murta Rezende Moraes Ribeiro, Beatriz, Marques Cassani, Natasha, Nascimento Farago, Danilo, André Antoniucci, Giovanna, Eduardo de Oliveira Rocha, Rafael, de Oliveira Souza, Felipe, Jorge Pilau, Eduardo, Carolina Gomes Jardim, Ana, Salgado Ferreira, Rafaela, de Oliveira Rezende Júnior, Celso

“…[Display omitted] •• Design, synthesis, and antiviral activity of N-acyl-2-aminobenzothiazole derivatives.•• The N-acyl-2-aminobenzothiazole class is a…”
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Structure-activity relationships of novel N -imidazoylpiperazines with potent anti- Trypanosoma cruzi activity by Espinoza-Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso de, de Souza, Mariana Laureano, Pauli, Ivani, Valli, Marilia, Gomes Ferreira, Leonardo Luiz, Chelucci, Rafael Consolin, Michelan-Duarte, Simone, Krogh, Renata, Romualdo da Silva, Fernando Bezerra, Cruz, Fábio Cardoso, de Oliveira, Aldo Sena, Andricopulo, Adriano Defini, Dias, Luiz Carlos

“…Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of…”
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Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles by Oliveira, Douglas Davison da Silva, Silva, Nagela Bernadelli Sousa, Lapierre, Thibault Joseph William Jacques Dit, de Souza, Sara Lemes, Brito, Nícolas Peterson Ferreira, Martinho, Ana Clara Cassiano, Clemente Dias, Renieidy Flávia, Farago, Danilo Nascimento, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Cruz, Mariza Gabriela Faleiro de Moura Lodi, de Melo Resende, Daniela, Andricopulo, Adriano D, Murta, Silvane Maria Fonseca, Ferreira, Leonardo L G, Gomes Martins, Carlos Henrique, de Oliveira Rezende Júnior, Celso

“…Microorganisms can induce diseases with significant clinical implications for human health. Multidrug-resistant microorganisms have been on the rise worldwide…”
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