Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer

Piperine, an active plant alkaloid from black pepper ), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate th...

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Published in:	International journal of molecular sciences Vol. 25; no. 11; p. 5762
Main Authors:	Gusson-Zanetoni, Juliana Prado, Cardoso, Luana Pereira, de Sousa, Stefanie Oliveira, de Melo Moreira Silva, Laura Luciana, de Oliveira Martinho, Júlia, Henrique, Tiago, Tajara, Eloiza Helena, Oliani, Sonia Maria, Rodrigues-Lisoni, Flávia Cristina
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-06-2024 MDPI
Subjects:	Alkaloids - pharmacology Apoptosis Apoptosis - drug effects Benzodioxoles - pharmacology Cancer Cancer therapies Cell cycle Cell death Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Chemical compounds Cytokines Cytokines - metabolism Cytotoxicity Development and progression Gene Expression Regulation, Neoplastic - drug effects Genes Genetic aspects Head & neck cancer Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Health aspects herbal medicine Humans Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - metabolism Kinases MAPK Metabolites Metastasis MMPs Morphology Mortality Natural products Pathogenesis Phytochemicals Piperidines - pharmacology Piperidines - therapeutic use Polyunsaturated Alkamides - pharmacology Proteins PTGS2 Signal Transduction - drug effects Thyroid gland cytokines MAPK PTGS2 inflammation herbal medicine MMPs
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Summary:	Piperine, an active plant alkaloid from black pepper ), has several pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory effects, which involve inhibiting molecular events associated with various stages of cancer development. The aim of this study was to investigate the molecular mechanisms of action of piperine in relation to its potential anticancer effect on head and neck cancer cells. Parameters related to neoplastic potential and cytokine, protein and gene expression were investigated in head and neck cancer cell lines (HEp-2 and SCC-25) treated with piperine. The results of the tests indicated that piperine modified morphology and inhibited viability and the formation of cell colonies. Piperine promoted genotoxicity by triggering apoptosis and cell cycle arrest in the G2/M and S phases. A decrease in cell migration was also observed, and there was decreased expression of MMP2/9 genes. Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN- and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25115762