Candida albicans isolated from denture-related stomatitis in elderly patients: Antifungal susceptibility and production of virulence attributes

Candida albicans isolated from denture-related stomatitis in elderly patients: Antifungal susceptibility and production of virulence attributes

Denture-related stomatitis caused by Candida spp. affects elderly individuals using partial/total prosthesis, provoking several discomforts including burning sensation and altered taste. Herein, we have studied 52 denture-wearing individuals (>60 years-old), attended at the dentistry clinic of UN...

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Bibliographic Details
Published in:Experimental Results Vol. 1
Main Authors: de Sousa, Lourimar Viana Nascimento Franco, de Oliveira Maia, Carlos Davi, Carvalho, Isadora Sousa, Prata, Juliano Meireles, Arcanjo, Larissa Carla Rodrigues, de Figueiredo Vieira, Marina, Martins, Matheus Batista, Pereira, Thais Silveira, Souza, Lucieri Olegário Pereira, Galdino, Anna Clara Milesi, Branquinha, Marta Helena, Canela, Heliara Maria Spina, Santos, André Luis Souza
Format: Journal Article
Language:English
Published: Cambridge Cambridge University Press 2020
Subjects:
Antifungal resistance
Biofilms
Biomass
Candida
Codes
Dentistry
Denture
Enzymes
Ethics
Experiments
Females
Laboratories
Metabolism
Oral hygiene
Prostheses
Stomatitis
Virulence
Virulence factors
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Summary:Denture-related stomatitis caused by Candida spp. affects elderly individuals using partial/total prosthesis, provoking several discomforts including burning sensation and altered taste. Herein, we have studied 52 denture-wearing individuals (>60 years-old), attended at the dentistry clinic of UNIVALE, aiming to isolate Candida spp. directly from the stomatitis lesions and to evaluate their potential to produce virulence attributes. A low prevalence of denture-related stomatitis was reported in these patients (4/52; 7.7%). Candida albicans was isolated in the 4 selected patients, with the ability to form biofilm over a polystyrene surface and to produce aspartic protease, esterase and hemolysin. However, neither phospholipase nor caseinase activities were detected. Planktonic-growing yeasts were susceptible to amphotericin B and caspofungin, while the susceptibility to azoles (fluconazol, itraconazole and voriconazole) varied depending on either the isolate or antifungal. Relevantly, biofilm-forming C. albicans cells exhibited resistance to all studied antifungals. So, new effective drugs against resistant C. albicans isolates causing denture-related stomatitis are urgently required.
ISSN:2516-712X
2516-712X
DOI:10.1017/exp.2020.49