Waterborne Risperidone Decreases Stress Response in Zebrafish

The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behav...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 10; p. e0140800
Main Authors:	Idalencio, Renan, Kalichak, Fabiana, Rosa, João Gabriel Santos, de Oliveira, Tiago Acosta, Koakoski, Gessi, Gusso, Darlan, Abreu, Murilo Sander de, Giacomini, Ana Cristina Varrone, Barcellos, Heloísa Helena de Alcântara, Piato, Angelo L, Barcellos, Leonardo José Gil
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16-10-2015 Public Library of Science (PLoS)
Subjects:	Animals Anti-Anxiety Agents - adverse effects Anti-Anxiety Agents - pharmacology Antipsychotics Anxiety Anxiolytics Aquatic environment Aquatic organisms Behavior, Animal - drug effects Danio rerio Fish Health aspects Hormones Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - pathology Hypothalamus Metabolites Municipal wastewater Physiological aspects Pituitary Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - pathology Psychological aspects Psychotropic drugs Risk factors Risperidone Risperidone - adverse effects Risperidone - pharmacology Schizophrenia Stress (Psychology) Stress response Surface water Water Pollutants, Chemical - adverse effects Water Pollutants, Chemical - pharmacology Zebrafish Zebrafish - metabolism Brazil
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Summary:	The presence of drugs and their metabolites in surface waters and municipal effluents has been reported in several studies, but its impacts on aquatic organisms are not yet well understood. This study investigated the effects of acute exposure to the antipsychotic risperidone on the stress and behavioral responses in zebrafish. It became clear that intermediate concentration of risperidone inhibited the hypothalamic-pituitary-interrenal axis and displayed anxiolytic-like effects in zebrafish. The data presented here suggest that the presence of this antipsychotic in aquatic environments can alter neuroendocrine and behavior profiles in zebrafish.
Bibliography:	Conceived and designed the experiments: LJGB RI MSA ACVG. Performed the experiments: RI MSA FK ACVG GK DG TAO JGSR. Analyzed the data: RI MSA ALP LJGB. Contributed reagents/materials/analysis tools: HHAB. Wrote the paper: LJGB RI ALP. Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0140800