Search Results - "de Oliveira, Roberto Ferreira"
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Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
Published in Journal of oncology (2021)“…The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we…”
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Preclinical anticancer effectiveness of a fraction from Casearia sylvestris and its component Casearin X: in vivo and ex vivo methods and microscopy examinations
Published in Journal of ethnopharmacology (20-06-2016)“…Casearia sylvestris (Salicaceae) is found in South America and presents antiulcerogenic, cytotoxic, antimicrobial, anti-inflammatory and antihypertensive…”
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Chemopreventive effect of troxerutin against hydrogen peroxide-induced oxidative stress in human leukocytes through modulation of glutathione-dependent enzymes
Published in Journal of Toxicology and Environmental Health, Part A (16-02-2021)“…Troxerutin is a natural flavonoid present abundantly in tea, coffee, olives, wheat, and a variety of fruits and vegetables. Due to its diverse pharmacological…”
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Clinical and Molecular Characterization of Brazilian Patients Suspected to Have Lynch Syndrome
Published in PloS one (05-10-2015)“…Lynch syndrome (LS) accounts for 3-5% of all colorectal cancers (CRC) and is inherited in an autosomal dominant fashion. This syndrome is characterized by…”
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Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-12-2020)“…The compound (+)-limonene epoxide has antioxidant, anxiolytic, and antihelminthic properties. However, investigations to determine its long-term exposure were…”
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Etomidate is devoid of genotoxicty and mutagenicity in human lymphocytes and in the Salmonella typhimurium/microsomal activation test
Published in Toxicology in vitro (01-10-2020)“…No carcinogenesis or mutagenesis studies have been carried out with etomidate. The current study showed that etomidate has weak cytotoxic potential after 48 h…”
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Evaluation of Genotoxicity and Mutagenicity of Ketamine on Human Peripheral Blood Leukocytes and in Salmonella typhimurium
Published in Toxicology in vitro (01-02-2020)“…Ketamine is a potent uncompetitive NMDA receptor antagonist that provides amnesia, analgesia, environmental dissociation and immobility, where it has its…”
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Protective and therapeutic potential of ginger (Zingiber officinale) extract and [6]‐gingerol in cancer: A comprehensive review
Published in Phytotherapy research (01-10-2018)“…Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger,…”
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Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms
Published in Pharmacological research (01-06-2021)“…Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to relieve acute and chronic inflammatory diseases. In this article, we present a…”
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Antimitotic and toxicogenetic action of Stevia urticifolia aerial parts on proliferating vegetal and mammalian cells: in vitro and in vivo traditional and replacement methods
Published in Journal of Toxicology and Environmental Health, Part A (17-09-2022)“…Stevia urticifolia Thunb. is an underexploited herb possessing bioactive flavonoids, saponins, and terpenoids. The aim of this study was to examine the…”
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Inclusão da pessoa com deficiência em um Centro de Referência em DST/AIDS de um município baiano
Published in Revista Brasileira de Enfermagem (01-04-2013)“…O presente estudo, de abordagem qualitativa, buscou conhecer a opinião dos profissionais de saúde sobre a inclusão das pessoas com deficiência nas atividades…”
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Antitumoral effects of [6]-gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] in sarcoma 180 cells through cytogenetic mechanisms
Published in Biomedicine & pharmacotherapy (01-06-2020)“…[Display omitted] •[6]-Gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] is a phenolic substance with several pharmacological…”
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Hellebrigenin triggers death of promyelocytic leukemia cells by non-genotoxic ways
Published in Toxicon (Oxford) (01-02-2024)“…Bufadienolides are digitalis-like aglycones mainly found in skin secretions of toads. Among their biological properties, the mechanisms of antiproliferative…”
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Anticancer effects of phytol against Sarcoma (S-180) and Human Leukemic (HL-60) cancer cells
Published in Environmental science and pollution research international (01-07-2023)“…Phytol (Pyt), a diterpenoid, possesses many important bioactivities. This study evaluates the anticancer effects of Pyt on sarcoma 180 (S-180) and human…”
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Toxicological findings about an anticancer fraction with casearins described by traditional and alternative techniques as support to the Brazilian Unified Health System (SUS)
Published in Journal of ethnopharmacology (15-09-2019)“…Extracts, essential oils and molecules from Casearia sylvestris have popularly shown pharmacological actions against chronic diseases, as anxiety,…”
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Pharmacological and physicochemical profile of arylacetamides as tools against human cancers
Published in Toxicology and applied pharmacology (01-10-2019)“…Arylacetamides are widely used as synthetic intermediates to obtain medicinal substances. This work evaluated in vitro antiproliferative activity of ten…”
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Antitumor effects of citrinin in an animal model of Sarcoma 180 via cytogenetic mechanisms
Published in Cellular and Molecular Biology (25-06-2020)“…Citrinin (CIT) is a cytotoxic, hepatotoxic, nephrotoxic and cardiotoxic metabolite obtained from Penicillium citrinum, that has been increasingly searched as…”
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Toxic, cytogenetic and antitumor evaluations of [6]-gingerol in non-clinical in vitro studies
Published in Biomedicine & pharmacotherapy (01-07-2019)“…Gingerol - [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone; [6]-G) - is a phenolic compound with several pharmacological properties…”
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Screening for Structural Hemoglobin Variants in Bahia, Brazil
Published in International journal of environmental research and public health (01-02-2016)“…Brazil was the country that received the largest number of Africans during the time of colonization, and Bahia was the Brazilian state that received the…”
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Inclusion of persons with disabilities in a Reference Center for STD / AIDS of a town in Bahia, Brazil
Published in Revista brasileira de enfermagem (01-03-2013)“…This qualitative study sought to ascertain the opinion of health professionals about the inclusion of people with disabilities in the activities of reception,…”
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