Plasma fatty acids: Biomarkers of dietary intake?

Plasma fatty acids: Biomarkers of dietary intake?

•To our knowledge, there is currently no consensus in the literature on the association between dietary fatty acids and circulating levels in plasma.•Low correlation and agreement were found between dietary and plasma fatty acids.•The results of this study do not support the use of plasma fatty acid...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Vol. 59; pp. 77 - 82
Main Authors: Marchioni, Dirce Maria, de Oliveira, Mayara Freitas, Carioca, Antonio Augusto Ferreira, Miranda, Andreia A. Machado, Carvalho, Aline Martins, Oki, Erica, Norde, Marina Maintinguer, Rogero, Marcelo Macedo, Damasceno, Nagila Raquel Teixeira, Fisberg, Regina Mara
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-03-2019
Elsevier Limited
Subjects:
Adolescent
Adult
Adults
Anthropometry
Biomarkers
Biomarkers - blood
Brazil
Cardiovascular diseases
Child
Chromatography, Gas
Correlation analysis
Cross-Sectional Studies
Data collection
Demographics
Diet
Diet - statistics & numerical data
Diet Surveys
Dietary Fats - analysis
Dietary intake
Docosahexaenoic acid
Docosahexaenoic Acids - blood
Eating
Fatty acids
Fatty Acids - blood
Female
Food
Food intake
Gas chromatography
Health Surveys
Households
Humans
Linear Models
Male
Middle Aged
Nutrition
Plasma
Questionnaires
Regression analysis
Sociodemographics
Software
Statistical analysis
Statistics, Nonparametric
Young Adult
Brazil
United States > US
Dietary intake
Diet
Cardiovascular diseases
Fatty acids
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Summary:•To our knowledge, there is currently no consensus in the literature on the association between dietary fatty acids and circulating levels in plasma.•Low correlation and agreement were found between dietary and plasma fatty acids.•The results of this study do not support the use of plasma fatty acids as biomarkers of dietary fatty acids. To our knowledge, there is currently no consensus in the literature on the association between dietary fatty acids and circulating levels in plasma. The aim of this study was to assess the association of the intake of fatty acids with their relative plasma concentrations. We conducted a study with 300 adults from the population-based health survey in São Paulo city (ISA-Capital 2008). We assessed demographic, lifestyle and anthropometric data, biochemical measurements, and two 24-h dietary recalls collected on non-consecutive days. Intake distribution was adjusted for intrapersonal variance to give usual dietary intake using the multiple source method (MSM). Percentage of fatty acids in plasma were analyzed by gas chromatography. The κ statistic, Spearman's correlation, and multiple linear regression (adjusted for confounders) and ratio limits of agreement were employed to determine the relationship between plasma and dietary measurements. Low correlation and agreement were found between dietary and plasma fatty acids. Docosahexaenoic acid (β = 0.25; P < 0.001) and saturated (β = 0.19; P = 0.048) fatty acids exhibited an association for means of intake adjusted by the MSM and for confounding variables. A large mean difference, with a large variation of “ratio limits,” were observed between the measurements. Plasma and dietary polyunsaturated and saturated fatty acids exhibited low correlation and agreement, as well as weak association between each other. No association between intake and plasma concentrations of monounsaturated fat was found. Plasma fatty acids are not good biomarkers of food intake.
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content type line 23
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2018.08.008