Search Results - "de Oliveira, Isadora Sousa"
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From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery
Published in Frontiers in pharmacology (24-07-2020)“…Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an…”
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Snake venom disintegrins update: insights about new findings
Published in The journal of venomous animals and toxins including tropical diseases (2023)“…Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine, present in the venom of snakes from the families Viperidae,…”
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3
Anti-vaccination movements in the world and in Brazil
Published in Revista da Sociedade Brasileira de Medicina Tropical (2022)“…Over the years, vaccinations have provided significant advances in public health, because they substantially reduce the morbimortality of vaccine-preventable…”
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4
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components
Published in The journal of venomous animals and toxins including tropical diseases (2024)“…scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While…”
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Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway
Published in The journal of venomous animals and toxins including tropical diseases (2024)“…Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. There is no effective treatment for neurodegenerative diseases. Snake venoms…”
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Antivenomic approach of different Crotalus durissus collilineatus venoms
Published in The journal of venomous animals and toxins including tropical diseases (26-11-2018)“…Our group has previously performed a proteomic study verifying that individual variations can occur among venoms. These variations may lead to differences in…”
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7
Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Published in The journal of venomous animals and toxins including tropical diseases (2018)“…In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and…”
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Snake venom vascular endothelial growth factors (svVEGFs): Unravelling their molecular structure, functions, and research potential
Published in Cytokine & growth factor reviews (01-08-2021)“…[Display omitted] •This is the pioneer review exploring snake venom vascular endothelial growth factors (svVEGFs) discoveries.•svVEGFs are minor snake-derived…”
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MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin
Published in Biochemical pharmacology (01-11-2021)“…[Display omitted] Cardiac transition from concentric (C-LVH) to eccentric left ventricle hypertrophy (E-LVH) is a maladaptive response of hypertension. Matrix…”
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10
State-of-the-art review of snake venom phosphodiesterases (svPDEs)
Published in Toxicon (Oxford) (15-10-2022)“…Phosphodiesterases (PDEs) constitute an enzyme group able to hydrolyze nucleic acids as well as some second messengers. Due to this ability and their…”
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Towards toxin PEGylation: The example of rCollinein-1, a snake venom thrombin-like enzyme, as a PEGylated biopharmaceutical prototype
Published in International journal of biological macromolecules (01-11-2021)“…PEGylation was firstly described around 50 years ago and has been used for more than 30 years as a strategy to improve the drugability of biopharmaceuticals…”
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Global proteomic and functional analysis of Crotalus durissus collilineatus individual venom variation and its impact on envenoming
Published in Journal of proteomics (16-01-2019)“…Individual variations studies are important to understand the snakebite envenoming and to improve the antivenom production and its effectiveness. In this way,…”
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Unraveling the structure and function of CdcPDE: A novel phosphodiesterase from Crotalus durissus collilineatus snake venom
Published in International journal of biological macromolecules (01-05-2021)“…This study reports the isolation, structural, biochemical, and functional characterization of a novel phosphodiesterase from Crotalus durissus collilineatus…”
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14
The State-of-the-Art of the Humoral Memory Response to Snakebites: Insights from the Yanomami Population
Published in Toxins (01-11-2023)“…Snakebite envenomation (SBE)-induced immunity refers to individuals who have been previously bitten by a snake and developed a protective immune response…”
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15
Bothrops bilineatus : An Arboreal Pitviper in the Amazon and Atlantic Forest
Published in Frontiers in immunology (15-12-2021)“…The two-striped forest-pitviper ( ) is an arboreal snake that is currently represented by two subspecies ( and ) that comprise a species complex, and its…”
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Antifungal activity of Rhopalurus crassicauda venom against Candida spp
Published in Toxicon X (01-06-2022)“…Fungal infections are becoming a serious problem of human diseases, being one of the most important fungal pathogens the yeast of the genus Candida. So far,…”
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Potencial do tratamento fitoterápico no climatério versus terapia hormonal
Published in Health and Diversity (19-11-2020)“…Introdução: A menopausa é um marco na vida da mulher, caracterizado ao final do ciclo reprodutivo, antes e após a menopausa, a mulher passa por alterações…”
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Isolation, structural characterization of the first disintegrin from Bothrops moojeni venom and its antitumor activity in acute myeloid leukemia
Published in Toxicon (Oxford) (01-09-2024)Get full text
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Effects of crotamine in human prostate cancer cell line
Published in Toxicon (Oxford) (28-05-2024)“…Our study presents the anticancer potential of crotamine from Crotalus durissus terrificus in human prostate cancer cell line DU-145. Crotamine isolation was…”
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Moojecin: The first disintegrin from Bothrops moojeni venom and its antitumor activity in acute myeloid leukemia
Published in International journal of biological macromolecules (01-11-2024)“…Disintegrins are a class of peptides found in snake venom that inhibit the activity of integrins, which are essential cell adhesion receptors in tumor…”
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