Search Results - "de Oliveira, Haroldo César"
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Paracoccidoides brasiliensis 30 kDa adhesin: identification as a 14-3-3 protein, cloning and subcellular localization in infection models
Published in PloS one (30-04-2013)“…Paracoccidoides brasiliensis adhesion to lung epithelial cells is considered an essential event for the establishment of infection and different proteins…”
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Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
Published in PLoS pathogens (18-05-2018)“…Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by…”
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Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris
Published in Frontiers in cellular and infection microbiology (02-04-2019)“…is an emerging fungal pathogen of great concern among the scientific community because it is causing an increasing number of hospital outbreaks of difficult…”
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In vitro synergistic effects of fluoxetine and paroxetine in combination with amphotericin B against Cryptococcus neoformans
Published in Pathogens and disease (01-03-2021)“…ABSTRACT Cryptococcus neoformans is a yeast that mainly affects immunocompromised individuals and causes meningoencephalitis depending on the immune status of…”
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Correction: Paracoccidoides brasiliensis 30 kDa Adhesin: Identification as a 14-3-3 Protein, Cloning and Subcellular Localization in Infection Models
Published in PloS one (30-10-2015)Get full text
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Decreased expression of 14-3-3 in Paracoccidioides brasiliensis confirms its involvement in fungal pathogenesis
Published in Virulence (17-02-2016)“…The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the…”
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Influence of the Paracoccidioides brasiliensis 14-3-3 and gp43 proteins on the induction of apoptosis in A549 epithelial cells
Published in Memórias do Instituto Oswaldo Cruz (01-06-2015)“…The fungal strain Paracoccidioides brasiliensis remains viable inside of epithelial cells and can induce apoptosis in this population. However, until now, the…”
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Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp
Published in Antimicrobial agents and chemotherapy (24-03-2020)“…Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated with its toxicity…”
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Extracellular Vesicles Regulate Biofilm Formation and Yeast-to-Hypha Differentiation in Candida albicans
Published in mBio (28-06-2022)“…In this study, we investigated the influence of fungal extracellular vesicles (EVs) during biofilm formation and morphogenesis in Candida albicans. Using…”
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Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans
Published in Molecular microbiology (01-04-2019)“…Summary Ppz Ser/Thr protein phosphatases (PPases) are found only in fungi and have been proposed as potential antifungal targets. In Saccharomyces cerevisiae…”
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Corrigendum: Importance of adhesins in virulence of Paracoccidioides spp
Published in Frontiers in microbiology (05-05-2015)Get full text
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Cell Wall Integrity Pathway Involved in Morphogenesis, Virulence and Antifungal Susceptibility in Cryptococcus neoformans
Published in Journal of fungi (Basel) (05-10-2021)“…Due to its location, the fungal cell wall is the compartment that allows the interaction with the environment and/or the host, playing an important role during…”
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Heat Shock Protein 60, Insights to Its Importance in Histoplasma capsulatum : From Biofilm Formation to Host-Interaction
Published in Frontiers in cellular and infection microbiology (22-01-2021)“…Heat shock proteins (Hsps) are among the most widely distributed and evolutionary conserved proteins, acting as essential regulators of diverse constitutive…”
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Polypeptides Targeting Paracoccidioides brasiliensis Drk1
Published in Journal of fungi (Basel) (29-09-2023)“…Considering the toxicity of conventional therapeutic approaches and the importance of precise mechanistic targets, it is important to explore signaling…”
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Importance of adhesins in virulence of Paracoccidioides spp
Published in Frontiers in microbiology (2015)“…Members of the Paracoccidioides genus are the etiologic agents of paracoccidioidomycosis (PCM). This genus is composed of two species: Paracoccidioides…”
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Drk1, a Dimorphism Histidine Kinase, Contributes to Morphology, Virulence, and Stress Adaptation in Paracoccidioides brasiliensis
Published in Journal of fungi (Basel) (12-10-2021)“…P. brasiliensis is a thermally dimorphic fungus belonging to Paracoccidioides complex, causative of a systemic, endemic mycosis limited to Latin American…”
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In Vitro and In Vivo Effect of Peptides Derived from 14-3-3 Paracoccidioides spp. Protein
Published in Journal of fungi (Basel) (13-01-2021)“…Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and requires prolonged treatment; therefore, new therapeutic approaches are necessary…”
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The multifaceted roles of metabolic enzymes in the Paracoccidioides species complex
Published in Frontiers in microbiology (19-12-2014)“…Paracoccidioides species are dimorphic fungi and are the etiologic agents of paracoccidioidomycosis, which is a serious disease that involves multiple organs…”
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Screening of the global health priority BoxⓇ reveals potential new disinfectants against the emerging multidrug-resistant pathogen Candida auris
Published in Microbial pathogenesis (01-09-2024)“…Candida auris has been identified by the World Health Organization as a critical pathogen due to its invasive nature, resistance to multiple drugs, and high…”
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Participation of Zip3, a ZIP domain-containing protein, in stress response and virulence in Cryptococcus gattii
Published in Fungal genetics and biology (01-11-2020)“…•Cryptococcus gattii Zip3 is ortholog to Saccharomyces cerevisiae Atx2p.•Cryptococcal cells rely on the proper expression of Zip3 to sustain stress…”
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