Development of a new highly sensitive electrochemical sensor to piroxicam anti-inflammatory determination using a disposable screen-printed electrode

Development of a new highly sensitive electrochemical sensor to piroxicam anti-inflammatory determination using a disposable screen-printed electrode

In this study, a novel analytical method was developed for determining piroxicam, employing a modified screen-printed carbon electrochemical sensor. This sensor utilizes a nanomaterial composed of reduced graphene oxide with antimony nanoparticles (rGO-SbNPs), which was characterized by transmission...

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Bibliographic Details
Published in:Ionics Vol. 30; no. 5; pp. 2793 - 2806
Main Authors: de Oliveira, Gustavo Zanon de Moraes Goes, Silva, Francisco Walison Lima, Lopes, Claudio Sabbatini Capella, Braz, Bernardo Ferreira, Santelli, Ricardo Erthal, Cincotto, Fernando Henrique
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2024
Springer Nature B.V
Subjects:
Antimony
Ascorbic acid
Calcium ions
Carbon
Chemical sensors
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Drinking water
Electrochemistry
Electrodes
Electron microscopy
Electrons
Energy Storage
Galactose
Graphene
Lactose
Microscopy
Nanomaterials
Optical and Electronic Materials
Renewable and Green Energy
Screen printing
Sensors
Synergistic effect
Voltammetry
Low-cost
Screen-printed electrode
Antimony nanoparticles
Piroxicam
Reduced graphene oxide
Electrochemical sensor
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Summary:In this study, a novel analytical method was developed for determining piroxicam, employing a modified screen-printed carbon electrochemical sensor. This sensor utilizes a nanomaterial composed of reduced graphene oxide with antimony nanoparticles (rGO-SbNPs), which was characterized by transmission electron microscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, and electrochemical methods. The rGO-SbNPs demonstrated a significant synergistic effect on the sensor’s performance. Utilizing the cyclic voltammetry technique, the analyte was found to oxidize irreversibly around + 0.30 V. Employing differential pulse voltammetry, the sensor exhibited a broad linear range from 0.808 to 130.0 µmol L −1 , with a detection limit of 0.0201 µmol L −1 — the lowest reported for piroxicam on screen-printed carbon electrodes in the literature — and a quantification limit of 0.0610 µmol L −1 . It also demonstrated good reproducibility, evidenced by a relative standard deviation of 4.66%. Additionally, the sensor showed high selectivity for the analyte even in the presence of various compounds and ions such as flunixin meglumine, ascorbic acid, glucose, lactose, galactose, Ca 2+ , Cl − , and Na + . The device was successfully applied to tap water and bovine milk samples, yielding satisfactory recoveries: 106.0, 104.0, and 101.0% for water, and 89.9, 97.4, and 93.7% for milk. Graphical abstract
ISSN:0947-7047
1862-0760
DOI:10.1007/s11581-024-05444-1