Natural cordiaquinones as strategies to inhibit the growth and biofilm formation of methicillin-sensitive and methicillin-resistant Staphylococcus spp

The aim of this study was to investigate the antibacterial and antibiofilm potential of cordiaquinones B, E, L, N, and O against different Staphylococci strains, in addition to analyzing in silico the observed effect. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentrat...

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Bibliographic Details
Published in:	Journal of applied microbiology Vol. 134; no. 8
Main Authors:	de Oliveira, Mariana Araújo, Barros, Ayslan Batista, de Araújo, Gisele Santos, de Araújo, Alyne Rodrigues, José Dos Santos Soares, Maria, de Oliveira, Daiane Fernandes, Lima, Filipe Camargo Dalmatti Alves, Batagin-Neto, Augusto, Leite, José Roberto de Souza de Almeida, Cesário, Hozana Patrícia Silva de Freitas, Pessoa, Otília Deusdênia Loiola, Filho, José Delano Barreto Marinho, Araújo, Ana Jérsia
Format:	Journal Article
Language:	English
Published:	England 01-08-2023
Subjects:	Anti-Bacterial Agents - pharmacology Biofilms - drug effects Computer Simulation Cordia - chemistry Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Microbial Viability - drug effects Naphthoquinones - pharmacology Plant Extracts - isolation & purification Plant Extracts - pharmacology naphthoquinones antibacterial Cordia polycephala cordiaquinones antibiofilm
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Summary:	The aim of this study was to investigate the antibacterial and antibiofilm potential of cordiaquinones B, E, L, N, and O against different Staphylococci strains, in addition to analyzing in silico the observed effect. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined according to CLSI guidelines. The inhibition of biofilm formation was investigated at sub-MICs. Atomic force microscopy (AFM) and density functional theory method were performed. The tested strains of Staphylococcus spp. were susceptible to cordiaquinones B, E, and L, among which cordiaquinone B exerted a bactericidal effect, confirmed by a bacterial growth curve study, against Staphylococcus saprophyticus. Cordiaquinones B and E showed lowest MBC values against S. saprophyticus. AFM revealed that cordiaquinone L reduced the mean cell size of S. saprophyticus. Cordiaquinones B and E inhibited the biofilm formation ability of S. aureus by ∼90%. The in silico analysis suggested that the antimicrobial activity of cordiaquinones is driven by their electron donation capability. Cordiaquinones inhibit the growth and biofilm formation (virulence factor) of both methicillin-sensitive and methicillin-resistant Staphylococci strains, indicating their antimicrobial potential.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1365-2672 1365-2672
DOI:	10.1093/jambio/lxad162