Search Results - "de Nooij, Joriene C"
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Molecular correlates of muscle spindle and Golgi tendon organ afferents
Published in Nature communications (01-03-2021)“…Proprioceptive feedback mainly derives from groups Ia and II muscle spindle (MS) afferents and group Ib Golgi tendon organ (GTO) afferents, but the molecular…”
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Etv1 Inactivation Reveals Proprioceptor Subclasses that Reflect the Level of NT3 Expression in Muscle Targets
Published in Neuron (Cambridge, Mass.) (20-03-2013)“…The organization of spinal reflex circuits relies on the specification of distinct classes of proprioceptive sensory neurons (pSN), but the factors that drive…”
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Piezo2 is the principal mechanotransduction channel for proprioception
Published in Nature neuroscience (01-12-2015)“…Proprioception, the sense of body and limb position, begins in nerve cells called proprioceptors that are activated by muscle or joint stretch. The molecular…”
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Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Published in Neuron (Cambridge, Mass.) (19-03-2014)Get full text
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Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Published in Neuron (Cambridge, Mass.) (19-03-2014)“…Cutaneous mechanosensory neurons detect mechanical stimuli that generate touch and pain sensation. Although opioids are generally associated only with the…”
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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Published in Experimental physiology (01-01-2024)“…A metabotropic glutamate receptor coupled to phospholipase D (PLD‐mGluR) was discovered in the hippocampus over three decades ago. Its pharmacology and direct…”
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A Role for Runx Transcription Factor Signaling in Dorsal Root Ganglion Sensory Neuron Diversification
Published in Neuron (Cambridge, Mass.) (02-02-2006)“…Subpopulations of sensory neurons in the dorsal root ganglion (DRG) can be characterized on the basis of sensory modalities that convey distinct peripheral…”
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Engineering mechanoreceptor feature selectivity
Published in Neuron (Cambridge, Mass.) (18-10-2023)“…Touch and proprioception rely on the discriminative abilities of distinct classes of mechanosensory neurons. In this issue of Neuron, two studies1,2 provide…”
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MS and GTO proprioceptor subtypes in the molecular genetic era: Opportunities for new advances and perspectives
Published in Current opinion in neurobiology (01-10-2022)“…Proprioceptive feedback from skeletal muscle is an integral element of motor control, yet the precise physiological roles of muscle spindle (MS) and Golgi…”
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Influencers in the Somatosensory System: Extrinsic Control of Sensory Neuron Phenotypes
Published in The Neuroscientist (01-08-2023)“…Somatosensory neurons in dorsal root ganglia (DRG) comprise several main subclasses: high threshold nociceptors/thermoceptors, high- and low-threshold…”
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Graded Activity of Transcription Factor Runx3 Specifies the Laminar Termination Pattern of Sensory Axons in the Developing Spinal Cord
Published in Neuron (Cambridge, Mass.) (02-02-2006)“…Different functional classes of dorsal root ganglion sensory neurons project their axons to distinct target zones within the developing spinal cord. To explore…”
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The making of a proprioceptor: a tale of two identities
Published in Trends in neurosciences (Regular ed.) (01-12-2023)“…Proprioception, the sense of body position in space, has a critical role in the control of posture and movement. Aside from skin and joint receptors, the main…”
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Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies?
Published in Annual review of physiology (10-02-2023)“…The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory…”
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An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
Published in Neuron (Cambridge, Mass.) (05-01-2022)“…Proper assembly and function of the nervous system requires the generation of a uniquely diverse population of neurons expressing a cell-type-specific…”
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Airway Protection—A Role for Vagal P2RY1 Receptors
Published in Cell (30-04-2020)“…Recent events bring the importance of respiratory health to the forefront of our collective attention. In this issue of Cell, a new study by Prescott and Umans…”
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A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype
Published in The Journal of neuroscience (29-05-2019)“…Proprioceptive feedback from Group Ia/II muscle spindle afferents and Group Ib Golgi tendon afferents is critical for the normal execution of most motor tasks,…”
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Regulating muscle spindle and Golgi tendon organ proprioceptor phenotypes
Published in Current opinion in physiology (01-02-2021)“…Proprioception is an essential part of motor control. The main sensory subclasses that underlie this feedback control system — muscle spindle and Golgi tendon…”
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Runx1 Determines Nociceptive Sensory Neuron Phenotype and Is Required for Thermal and Neuropathic Pain
Published in Neuron (Cambridge, Mass.) (02-02-2006)“…In mammals, the perception of pain is initiated by the transduction of noxious stimuli through specialized ion channels and receptors expressed by nociceptive…”
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The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors
Published in The Journal of neuroscience (18-02-2015)“…Mechanoreception is an essential feature of many sensory modalities. Nevertheless, the mechanisms that govern the conversion of a mechanical force to distinct…”
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A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis
Published in Cell (27-12-1996)“…In a screen for genes that interact with the Rap1 GTPase, we have identified a Drosophila gene, dacapo (dap), which is a member of the p21/p27 family of cdk…”
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