Search Results - "de Murcia, Gilbert"

Radiation-induced mitotic catastrophe in PARG-deficient cells by Amé, Jean-Christophe, Fouquerel, Elise, Gauthier, Laurent R, Biard, Denis, Boussin, François D, Dantzer, Françoise, de Murcia, Gilbert, Schreiber, Valérie

“…Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and…”
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Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse by de Murcia, Gilbert, Ménissier de Murcia, Josiane, Ricoul, Michelle, Tartier, Laurence, Niedergang, Claude, Huber, Aline, Dantzer, Françoise, Schreiber, Valérie, Amé, Jean-Christophe, Dierich, Andrée, LeMeur, Marianne, Sabatier, Laure, Chambon, Pierre

“…The DNA damage‐dependent poly(ADP‐ribose) polymerases, PARP‐1 and PARP‐2, homo‐ and heterodimerize and are both involved in the base excision repair (BER)…”
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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells by Hochegger, Helfrid, Dejsuphong, Donniphat, Fukushima, Toru, Morrison, Ciaran, Sonoda, Eiichiro, Schreiber, Valérie, Zhao, Guang Yu, Saberi, Alihossein, Masutani, Mitsuko, Adachi, Noritaka, Koyama, Hideki, de Murcia, Gilbert, Takeda, Shunichi

“…Parp‐1 and Parp‐2 are activated by DNA breaks and have been implicated in the repair of DNA single‐strand breaks (SSB). Their involvement in double‐strand…”
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PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development by Huber, Aline, Bai, Peter, Murcia, Josiane Ménissier de, Murcia, Gilbert de

“…Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and nuclear proteins that contributes to the survival of…”
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Role of XRCC1 in the Coordination and Stimulation of Oxidative DNA Damage Repair Initiated by the DNA Glycosylase hOGG1 by Marsin, Stéphanie, Vidal, Antonio E., Sossou, Marguerite, Murcia, Josiane Ménissier-de, Le Page, Florence, Boiteux, Serge, de Murcia, Gilbert, Radicella, J.Pablo

“…XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. XRCC1 participation in these…”
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Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition by Aguilar-Quesada, Rocío, Muñoz-Gámez, José Antonio, Martín-Oliva, David, Peralta, Andreína, Valenzuela, Maria Teresa, Matínez-Romero, Rubén, Quiles-Pérez, Rosa, Menissier-de Murcia, Josiane, de Murcia, Gilbert, Ruiz de Almodóvar, Mariano, Oliver, F Javier

“…ATM and PARP-1 are two of the most important players in the cell's response to DNA damage. PARP-1 and ATM recognize and bound to both single and double strand…”
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PARP-1 is involved in autophagy induced by DNA damage by Muñoz-Gámez, José Antonio, Rodríguez-Vargas, José Manuel, Quiles-Pérez, Rosa, Aguilar-Quesada, Rocío, Martín-Oliva, David, de Murcia, Gilbert, de Murcia, Josiane Menissier, Almendros, Antonio, de Almodóvar, Mariano Ruiz, Oliver, F. Javier

“…Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. PARP-1 has been implicated in…”
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p53 Activation by Nitric Oxide Involves Down-regulation of Mdm2 by Wang, Xinjiang, Michael, Dan, de Murcia, Gilbert, Oren, Moshe

“…Nitric oxide (NO) is an important bioactive molecule involved in a variety of physiological and pathological processes. At the same time, NO is also an inducer…”
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PARP-1 modifies the effectiveness of p53-mediated DNA damage response by VALENZUELA, M. Teresa, GUERRERO, Rosario, NUNEZ, M. Isabel, RUIZ DE ALMODOVAR, J. Mariano, SARKER, Malabika, DE MURCIA, Gilbert, OLIVER, F. Javier

“…The tumour suppressor protein p53 plays a key role in the cell's decision to arrest the cell cycle or undergo apoptosis following a genotoxic insult. p53 is…”
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Poly(ADP-ribose): novel functions for an old molecule by Schreiber, Valérie, Dantzer, Françoise, Ame, Jean-Christophe, de Murcia, Gilbert

“…The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique…”
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PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis by Muñoz-Gámez, José Antonio, Martín-Oliva, David, Aguilar-Quesada, Rocío, Cañuelo, Ana, Nuñez, M Isabel, Valenzuela, M Teresa, Ruiz de Almodóvar, J M, De Murcia, Gilbert, Oliver, F Javier

“…p53 deficiency confers resistance to doxo (doxorubicin), a clinically active and widely used antitumour anthracycline antibiotic. The purpose of the present…”
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Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time by Nakamura, Jun, Asakura, Shoji, Hester, Susan D., de Murcia, Gilbert, Caldecott, Keith W., Swenberg, James A.

“…DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair…”
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The PARP superfamily by Amé, Jean-Christophe, Spenlehauer, Catherine, de Murcia, Gilbert

“…Poly(ADP‐ribosyl)ation is an immediate DNA‐damage‐dependent post‐translational modification of histones and other nuclear proteins that contributes to the…”
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Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice by Conde, Carmen, Mark, Manuel, Oliver, F.Javier, Huber, Aline, de Murcia, Gilbert, Ménissier-de Murcia, Josiane

“…PARP‐1‐deficient mice display a severe defect in the base excision repair pathway leading to radiosensitivity and genomic instability. They are protected…”
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Poly(ADP‐ribose) polymerase‐1 is a survival factor for radiation‐exposed intestinal epithelial stem cells in vivo by Ishizuka, Satoshi, Martin, Kareen, Booth, Catherine, Potten, Christopher S., de Murcia, Gilbert, Bürkle, Alexander, Kirkwood, Thomas B. L.

“…Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is a key enzyme mediating the cellular response to DNA strand breaks. It plays a critical role in genomic stability and…”
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Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1 by Schreiber, Valérie, Amé, Jean-Christophe, Dollé, Pascal, Schultz, Inès, Rinaldi, Bruno, Fraulob, Valérie, Ménissier-de Murcia, Josiane, de Murcia, Gilbert

“…The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we…”
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PARP-1 Determines Specificity in a Retinoid Signaling Pathway via Direct Modulation of Mediator by Pavri, Rushad, Lewis, Brian, Kim, Tae-Kyung, Dilworth, F. Jeffrey, Erdjument-Bromage, Hediye, Tempst, Paul, de Murcia, Gilbert, Evans, Ronald, Chambon, Pierre, Reinberg, Danny

“…We show that PARP-1 is indispensable to retinoic acid receptor (RAR)-mediated transcription from the RARβ2 promoter in a highly purified, reconstituted…”
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Poly(ADP-Ribose) Polymerase-2 Contributes to the Fidelity of Male Meiosis I and Spermiogenesis by Dantzer, Françoise, Mark, Manuel, Quenet, Delphine, Scherthan, Harry, Huber, Aline, Liebe, Bodo, Monaco, Lucia, Chicheportiche, Alexandra, Sassone-Corsi, Paolo, de Murcia, Gilbert, Ménissier-de Murcia, Josiane

“…Besides the established central role of poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 in the maintenance of genomic integrity, accumulating evidence…”
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Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair by Dantzer, Françoise, Amé, Jean-Christophe, Schreiber, Valérie, Nakamura, Jun, Ménissier-de Murcia, Josiane, de Murcia, Gilbert

“…Changes in chromatin structure emanating from DNA breaks are among the most initiating events in the damage response of the cell. In higher eukaryotes,…”
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XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage by Masson, Murielle, Niedergang, Claude, Schreiber, Valérie, Muller, Sylviane, Menissier-de Murcia, Josiane, de Murcia, Gilbert

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