Search Results - "de Moura Gallo, Claudia V"

Cognate DNA Stabilizes the Tumor Suppressor p53 and Prevents Misfolding and Aggregation by Ishimaru, Daniella, Ano Bom, Ana Paula D, Lima, Luís Maurício T. R, Quesado, Pablo A, Oyama, Marcos F. C, de Moura Gallo, Claudia V, Cordeiro, Yraima, Silva, Jerson L

“…The tumor suppressor protein p53 is a nuclear protein that serves as an important transcription factor. The region responsible for sequence-specific DNA…”
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Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors by Levy, Claudia B., Stumbo, Ana C., Ano Bom, Ana P.D., Portari, Elisabeth A., Carneiro, Yraima, Silva, Jerson L., De Moura-Gallo, Claudia V.

“…P53 is one of the most important tumor suppressor proteins in human cancers. Mutations in the TP53 gene are common features of malignant tumors and normally…”
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Prion-like aggregation of mutant p53 in cancer by Silva, Jerson L., Gallo, Claudia V. De Moura, Costa, Danielly C.F., Rangel, Luciana P.

“…•Prion-like aggregation of mutant p53 offers a novel mechanism of cancer pathogenesis.•The dominant-negative effects of p53 mutants are related to prion-like…”
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Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor by Silva, Jerson L, Rangel, Luciana P, Costa, Danielly C F, Cordeiro, Yraima, De Moura Gallo, Claudia V

“…p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains;…”
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XRCC1 gene polymorphisms in a population sample and in women with a family history of breast cancer from Rio de Janeiro (Brazil) by Falagan-Lotsch, Priscila, Rodrigues, Marina S, Esteves, Viviane, Vieira, Roberto, Amendola, Luis C, Pagnoncelli, Dante, Paixão, Júlio C, Gallo, Claudia V De Moura

“…The X-ray repair cross-complementing Group1 (XRCC1) gene has been defined as essential in the base excision repair (BER) and single-strand break repair…”
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Loop domain organization of the p53 locus in normal and breast cancer cells correlates with the transcriptional status of the TP53 and the neighboring genes by Goes, Andrea C.S., Cappellen, David, Santos Jr, Gilson C., Pirozhkova, Iryna, Lipinski, Marc, Vassetzky, Yegor, de Moura-Gallo, Claudia V.

“…P53 is a tumor suppressor protein critical for genome integrity. Although its control at the protein level is well known, the transcriptional regulation of the…”
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Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer by Ano Bom, Ana P D, Rangel, Luciana P, Costa, Danielly C F, de Oliveira, Guilherme A P, Sanches, Daniel, Braga, Carolina A, Gava, Lisandra M, Ramos, Carlos H I, Cepeda, Ana O T, Stumbo, Ana C, De Moura Gallo, Claudia V, Cordeiro, Yraima, Silva, Jerson L

“…Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant…”
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Epigenetic Modifications, Chromatin Distribution and TP53 Transcription in a Model of Breast Cancer Progression by Santos Jr, Gilson C., da Silva, Ana P. A., Feldman, Lucas, Ventura, Grasiella M., Vassetzky, Yegor, de Moura Gallo, Claudia V.

“…ABSTRACT In the present paper we aimed to characterize epigenetic aspects and analyze TP53 transcription in the 21 T series, composed of breast cell lines:…”
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Excision Close to Matrix Attachment Regions of the Entire Chicken α- Globin Gene Domain by Nuclease S1 and Characterization of the Framing Structures by Targa, Felix Recillas, Razin, Sergey V., Claudia V. De Moura Gallo, Scherrer, Klaus

“…Nuclease S1-hypersensitive sites in a 40-kb region of the chicken genome including the domain of the α-globin genes were mapped. Brief treatment of isolated…”
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TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: Association with risk factors and tumor characteristics by Simão, Tatiana A., Ribeiro, Fabiana S., Amorim, Lídia M. F., Albano, Rodolpho M., Andrada‐Serpa, Maria J., Cardoso, Lúis E. B., Mendonça, Gulnar A. S, de Moura‐Gallo, Cláudia V.

“…Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the…”
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MiR-34a is up-regulated in response to low dose, low energy X-ray induced DNA damage in breast cells by Stankevicins, Luiza, Almeida da Silva, Ana Paula, Ventura Dos Passos, Flavia, Dos Santos Ferreira, Evelin, Menks Ribeiro, Maria Cecilia, G David, Mariano, J Pires, Evandro, Ferreira-Machado, Samara Cristina, Vassetzky, Yegor, de Almeida, Carlos Eduardo, de Moura Gallo, Claudia Vitoria

“…MicroRNAs are non-coding RNAs involved in the regulation of gene expression including DNA damage responses. Low doses of low energy X-ray radiation, similar to…”
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Silencer and enhancer elements located at the 3'-side of the chicken and duck alpha-globin-encoding gene domains by Targa, F R, de Moura Gallo, C V, Huesca, M, Scherrer, K, Marcaud, L

“…Enhancer activities have been observed in DNA fragments up to 1.36 kb long located on the 3'-side of the cluster of the three alpha-type globin-encoding genes…”
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Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils by Ano Bom, Ana P.D., Rangel, Luciana P., Costa, Danielly C.F., de Oliveira, Guilherme A.P., Sanches, Daniel, Braga, Carolina A., Gava, Lisandra M., Ramos, Carlos H.I., Cepeda, Ana O.T., Stumbo, Ana C., De Moura Gallo, Claudia V., Cordeiro, Yraima, Silva, Jerson L.

“…Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant…”
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Analysis of the distribution of protein binding DNA motives in the vicinity of the 3'-side chicken alpha-globin enhancer by Targa, F R, de Moura Gallo, C V, Scherrer, K

“…DNA-protein interactions in the vicinity of the 3'-side chicken alpha-globin enhancer were analyzed in vitro. Downstream of the three GATA-1 motifs which…”
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