Photobiomodulation stimulates surrounding bone formation and increases stability of titanium alloy miniscrews in ovariectomized rats

Photobiomodulation stimulates surrounding bone formation and increases stability of titanium alloy miniscrews in ovariectomized rats

The number of older individuals (> 60 years) treated in orthodontic dental practice is constantly growing, and osteoporosis is a common disease within this age range. Orthodontic treatment for this group tends to be challenging, often requiring the use of mini-implants. Mini-implants are importan...

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Bibliographic Details
Published in:Lasers in medical science Vol. 37; no. 7; pp. 2917 - 2924
Main Authors: Martins, Bruna Guimarães, de Moura, Vanessa Santos, Fujii, Denise Nami, Garcez, Aguinaldo Silva, Suzuki, Selly Sayuri
Format: Journal Article
Language:English
Published: London Springer London 01-09-2022
Springer Nature B.V
Subjects:
Alizarin
Bone growth
Bone implants
Dental prosthetics
Dentistry
Euthanasia
Fluorescence
Fluorescence microscopy
Incisors
Irradiation
Laser applications
Lasers
Light therapy
Markers
Medicine
Medicine & Public Health
Optical Devices
Optics
Original Article
Orthodontics
Osteogenesis
Osteoporosis
Ovariectomy
Photonics
Quantum Optics
Shape memory alloys
Stability analysis
Systemic diseases
Titanium
Titanium alloys
Titanium base alloys
Transplants & implants
Tooth movement
Laser
Systemic disease
Laser therapy
Orthodontics
Adult orthodontic treatment
Mini-implant
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Summary:The number of older individuals (> 60 years) treated in orthodontic dental practice is constantly growing, and osteoporosis is a common disease within this age range. Orthodontic treatment for this group tends to be challenging, often requiring the use of mini-implants. Mini-implants are important accessories in orthodontic treatment that provide solutions to complex cases. Despite the high level of success, these devices are prone to failure if insufficient bone stability is achieved. This study aimed to evaluate the effects of photobiomodulation on bone neoformation around mini-implants using fluorescence analysis in ovariectomized rats. A total of 12 female rats (Wistar) were ovariectomized and divided into three groups: two groups of low-level laser therapy irradiation in two different protocols, as follows: in the PBM1 group, applications were performed using 2 J, for 20 s each for 48 h, 6 irradiations in total, and in the PBM2 group, a single application of 4 J was performed for 40 s, and the third group represented the control group, and no laser therapy was applied. Each rat received two mini-implants placed immediately behind the upper incisors, and 0 g of force was applied using a NiTi spring. All rats received two bone markers, tetracycline (days 0–4) and alizarin (days 7–10), for 5 days each. Both markers were bound to calcium, allowing visualization of bone neoformation through fluorescence microscopy. After 12 days, euthanasia was performed; the results revealed that both irradiated groups showed significantly greater bone neoformation compared to the control group ( p  < 0.05). Mini-implant stability was measured in all animals using the Periotest device on day 0 and on the day of euthanasia. A significant increase in stability was observed in the group that received more laser application ( p  < 0.05). Photobiomodulation had a positive effect on bone neoformation around mini-implants in ovariectomized rats, with an increase in stability when more irradiation was performed.
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ISSN:1435-604X
0268-8921
1435-604X
DOI:10.1007/s10103-022-03560-w