Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression

The aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weig...

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Bibliographic Details
Published in:Drug research Vol. 66; no. 7; p. 339
Main Authors: de Moura, C F G, Ribeiro, F A P, Handan, B A, Aguiar, O, Oshima, C T F, Ribeiro, D A
Format: Journal Article
Language:English
Published: Germany 01-07-2016
Subjects:
Animals
Cadmium Poisoning - enzymology
Cadmium Poisoning - pathology
Cadmium Poisoning - prevention & control
Cytochromes c - biosynthesis
Fruit and Vegetable Juices
Liver - drug effects
Liver - enzymology
Liver - pathology
Male
Matrix Metalloproteinase 2 - biosynthesis
Matrix Metalloproteinase 9 - biosynthesis
Necrosis - enzymology
Necrosis - pathology
Necrosis - prevention & control
Plant Extracts - pharmacology
Protective Agents - pharmacology
Rats
Vitis - chemistry
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Summary:The aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into 3 groups (n=5), as follows: Control group (non-treated group, CTRL); Cadmium group (Cd) and grape juice concentrate group (Cd+GJ). Histopathological analysis revealed that liver from animals treated with grape juice concentrate improved tissue degeneration induced by cadmium intoxication. Animals intoxicated with cadmium and treated with grape juice concentrate showed higher cytochrome C gene expression in liver cells. No significant statistically differences (p>0.05) were found to MMP 2 and 9 immunoexpression between groups. Taken together, our results demonstrate that grape juice concentrate is able to prevent tissue degeneration in rat liver as a result of increasing apoptosis.
ISSN:2194-9387
DOI:10.1055/s-0035-1569452