Search Results - "de Mota, Nadia"

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia by Flahault, Adrien, Girault-Sotias, Pierre-Emmanuel, Keck, Mathilde, Alvear-Perez, Rodrigo, De Mota, Nadia, Estéoulle, Lucie, Ramanoudjame, Sridévi M., Iturrioz, Xavier, Bonnet, Dominique, Llorens-Cortes, Catherine

“…Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor (apelin-R)…”
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Effects of firibastat in combination with enalapril and hydrochlorothiazide on blood pressure and vasopressin release in hypertensive DOCA-salt rats by Marc, Yannick, Hmazzou, Reda, De Mota, Nadia, Balavoine, Fabrice, Llorens-Cortes, Catherine

“…In the brain, aminopeptidase A (APA) generates angiotensin III, one of the effector peptides of the brain renin-angiotensin system (RAS), exerting tonic…”
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Apelin and Vasopressin: The Yin and Yang of Water Balance by Girault-Sotias, Pierre-Emmanuel, Gerbier, Romain, Flahault, Adrien, de Mota, Nadia, Llorens-Cortes, Catherine

“…Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in…”
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Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects by Gerbier, Romain, Alvear‐Perez, Rodrigo, Margathe, Jean‐Francois, Flahault, Adrien, Couvineau, Pierre, Gao, Ji, De Mota, Nadia, Dabire, Hubert, Li, Bo, Ceraudo, Emilie, Hus‐Citharel, Annette, Esteoulle, Lucie, Bisoo, Cynthia, Hibert, Marcel, Berdeaux, Alain, Iturrioz, Xavier, Bonnet, Dominique, Llorens‐Cortes, Catherine

“…ABSTRACT Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling cardiovascular functions and water balance. Because the in vivo apelin…”
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LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats via a NO Synthase-dependent Mechanism by Flahault, Adrien, Keck, Mathilde, Girault-Sotias, Pierre-Emmanuel, Esteoulle, Lucie, De Mota, Nadia, Bonnet, Dominique, Llorens-Cortes, Catherine

“…Apelin is a neuro-vasoactive peptide that plays a major role in the control of cardiovascular functions and water balance, but has an in-vivo half-life in the…”
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Reciprocal Regulation of Plasma Apelin and Vasopressin by Osmotic Stimuli by AZIZI, Michel, ITURRIOZ, Xavier, BLANCHARD, Anne, PEYRARD, Séverine, DE MOTA, Nadia, CHARTREL, Nicolas, VAUDRY, Hubert, CORVOL, Pierre, LLORENS-CORTES, Catherine

“…Apelin is a neuropeptide that co-localizes with vasopressin (AVP) in magnocellular neurons and is involved in body fluid homeostasis. Osmotic stimuli have…”
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Apelin, a Potent Diuretic Neuropeptide Counteracting Vasopressin Actions through Inhibition of Vasopressin Neuron Activity and Vasopressin Release by De Mota, Nadia, Goazigo, Annabelle Reaux-Le, El Messari, Said, Chartrel, Nicolas, Roesch, Darren, Dujardin, Cynthia, Kordon, Claude, Vaudry, Hubert, Moos, Françoise, Llorens-Cortes, Catherine, Hökfelt, Tomas

“…Apelin, a recently isolated neuropeptide that is expressed in the supraoptic and the paraventricular nuclei, acts on specific receptors located on…”
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Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure by Messari, Said El, Iturrioz, Xavier, Fassot, Celine, De Mota, Nadia, Roesch, Darren, Llorens‐Cortes, Catherine

“…Apelin is a novel neuropeptide involved in the regulation of body fluid homeostasis and cardiovascular functions. It acts through a G protein‐coupled receptor,…”
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Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging by Sauvant, Julie, Delpech, Jean-Christophe, Palin, Karine, De Mota, Nadia, Dudit, Jennifer, Aubert, Agnès, Orcel, Hélène, Roux, Pascale, Layé, Sophie, Moos, Françoise, Llorens-Cortes, Catherine, Nadjar, Agnès

“…Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized…”
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Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain by Reaux, Annabelle, De Mota, Nadia, Skultetyova, Ivana, Lenkei, Zsolt, El Messari, Said, Gallatz, Katalin, Corvol, Pierre, Palkovits, Miklos, Llorens‐Cortès, Catherine

“…Apelin, a peptide recently isolated from bovine stomach tissue extracts, has been identified as the endogenous ligand of the human orphan APJ receptor. We…”
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Cloning, pharmacological characterization and brain distribution of the rat apelin receptor by De Mota, N, Lenkei, Z, Llorens-Cortès, C

“…The peptide apelin, recently isolated from bovine stomach tissue extracts, has been identified as an endogenous ligand of the human putative receptor protein…”
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O98 NEW APPROACHES TARGETING THE RENIN-ANGIOTENSIN SYSTEM: BRAIN ACE2 ACTIVATION FOLLOWING BRAIN AMINOPEPTIDASE A BLOCKADE BY FIRIBASTAT IN SALT-DEPENDENT HYPERTENSION by Hmazzou, Réda, Marc, Yannick, Flahault, Adrien, De Mota, Nadia, Llorens-Cortes, Catherine

“…Background and Objective: In the brain, aminopeptidase A (APA), a membrane-bound zinc metalloprotease, generates angiotensin III from angiotensin II. Brain…”
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Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension by Hmazzou, Reda, Marc, Yannick, Flahault, Adrien, Gerbier, Romain, De Mota, Nadia, Llorens-Cortes, Catherine

“…In the brain, aminopeptidase A (APA), a membrane-bound zinc metalloprotease, generates angiotensin III from angiotensin II. Brain angiotensin III exerts a…”
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Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors by Balavoine, Fabrice, Compere, Delphine, Miege, Frédéric, De Mota, Nadia, Keck, Mathilde, Fer, Mickael, Christen, Aude, Martin, Emmeline, Roche, Didier, Llorens-Cortes, Catherine, Rodeschini, Vincent

“…[Display omitted] •The structure-based design of novel α-aminophosphinic derivatives inhibiting APA is described.•Their chemical synthesis is presented,…”
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Apelin is altered in subjects with autosomal dominant polycystic kidney disease and preserved kidney function by Janssens, Peter, Cools, Wilfried, de Mota, Nadia, Decuypere, Jean-Paul, Torres, Vicente, Wissing, Karl Martin, Vennekens, Rudi, Bammens, Bert, Llorens-Cortes, Catherine, Mekahli, Djalila

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A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension by Azizi, Michel, Courand, Pierre-Yves, Denolle, Thierry, Delsart, Pascal, Zhygalina, Valentina, Amar, Laurence, Lantelme, Pierre, Mounier-Vehier, Claire, De Mota, Nadia, Balavoine, Fabrice, Llorens-Cortes, Catherine

“…OBJECTIVES:We conducted a pilot multicenter double-blind randomized placebo-controlled crossover pharmacodynamic study to evaluate the blood pressure (BP) and…”
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Activating the apelin receptor with LIT01-196, a metabolically stable apelin analog, reverses AVP-induced antidiuresis and hyponatremia by Flahault, Adrien, Girault-Sotias, Pierre-Emmanuel, Keck, Mathilde, Alvear-Perez, Rodrigo, de Mota, Nadia, Estéoulle, Lucie, Ramanoudjame, Sridévi, Iturrioz, Xavier, Bonnet, Dominique, Llorens-Cortes, Catherine

“…Abstract Apelin and arginine-vasopressin (AVP) are conversely regulated by osmotic stimuli. We therefore hypothesized that activating the apelin receptor…”
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Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug by Balavoine, Fabrice, Azizi, Michel, Bergerot, Damien, De Mota, Nadia, Patouret, Rémi, Roques, Bernard P., Llorens-Cortes, Catherine

“…Background and Objectives Inhibition of brain aminopeptidase A (APA), which converts angiotensin II into angiotensin III, has emerged as a novel…”
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QGC606: A Best-in-Class Orally Active Centrally Acting Aminopeptidase A Inhibitor Prodrug for Treating Heart Failure Following Myocardial Infarction by Boitard, Solène E., Keck, Mathilde, Deloux, Robin, Girault-Sotias, Pierre-Emmanuel, Marc, Yannick, De Mota, Nadia, Compere, Delphine, Agbulut, Onnik, Balavoine, Fabrice, Llorens-Cortes, Catherine

“…Blockade of brain renin-angiotensin system (RAS) overactivity by firibastat, the first centrally acting aminopeptidase A (APA) inhibitor prodrug, has already…”
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Physiological role of the apelin receptor: implication in body fluid homeostasis and hyponatremia by Girault-Sotias, Pierre-Emmanuel, De Mota, Nadia, Llorens-Cortès, Catherine

“…Apelin, a vasoactive neuropeptide, its receptor and arginine-vasopressin (AVP, antidiuretic hormone) are co-localized in magnocellular vasopressinergic…”
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