sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before t...

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Published in:	Frontiers in medicine Vol. 10; p. 1177375
Main Authors:	Bezerra-Santos, Márcio, Bomfim, Lays G Santos, Santos, Camilla N Oliveira, Cunha, Maria Wiliane N, de Moraes, Eduardo J Rocha, Cazzaniga, Rodrigo A, Tenório, Martha D L, Araujo, Jonnia M Sherlock, Menezes-Silva, Lucas, Magalhães, Lucas Sousa, Barreto, Aline S, Reed, Steven G, Duthie, Malcolm S, Lipscomb, Michael W, de Almeida, Roque Pacheco, de Moura, Tatiana Rodrigues, de Jesus, Amélia Ribeiro
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 29-06-2023
Subjects:	immune markers inflammatory cytokine leprosy leprosy complications Medicine soluble TREM-1 leprosy immune markers inflammatory cytokine soluble TREM-1 leprosy complications
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Summary:	Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment ( = 51) and from their household contacts (HHCs; = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors share last authorship Reviewed by: Helioswilton Sales-Campos, Universidade Federal de Goiás, Brazil; Natália Aparecida De Paula, University of São Paulo, Brazil; Isabella Forasteiro Tavares, Oswaldo Cruz Foundation (FIOCRUZ), Brazil Edited by: Sebastian Vernal, University of São Paulo, Brazil
ISSN:	2296-858X 2296-858X
DOI:	10.3389/fmed.2023.1177375