Search Results - "de Monte, M"

Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease by de la Monte, Suzanne M

“…Alzheimer's disease [AD] is the most common cause of dementia in North America. Despite 30+ years of intense investigation, the field lacks consensus regarding…”
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Contributions of Brain Insulin Resistance and Deficiency in Amyloid-Related Neurodegeneration in Alzheimer’s Disease by de la Monte, Suzanne M.

“…Alzheimer’s disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is fundamentally a metabolic…”
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Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics by Guillon, A., Sécher, T., Dailey, L.A., Vecellio, L., de Monte, M., Si-Tahar, M., Diot, P., Page, C.P., Heuzé-Vourc’h, N.

“…[Display omitted] Acute and chronic respiratory diseases account for major causes of illness and deaths worldwide. Recent developments of biotherapeutics…”
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Chronic ethanol exposure causes mitochondrial dysfunction and oxidative stress in immature central nervous system neurons by Chu, Jennifer, Tong, Ming, de la Monte, Suzanne M

“…Cerebellar hypoplasia in experimental fetal alcohol syndrome (FAS) is associated with impaired insulin-stimulated survival signaling. In vitro studies…”
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Antinociceptive Effect of the Combination of a Novel α4β2 Agonist with Donepezil in a Chronic Pain Model by Monte, Fernanda B de M, Montagnoli, Tadeu L, Dematté, Bruno E, Gubert, Fernanda, Ventura, Vitória S, da Silva, Jaqueline S, Trachez, Margarete M, Mendez-Otero, Rosalia, Zapata-Sudo, Gisele

“…Chronic pain presents a major challenge in contemporary medicine, given the limited effectiveness and numerous adverse effects linked to available treatments…”
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Post-Polio Syndrome Revisited by Punsoni, Michael, Lakis, Nelli S, Mellion, Michelle, de la Monte, Suzanne M

“…Post-polio syndrome (PPS) is characterized by recrudescence or worsening of motor neuron disease symptoms decades after recovery from acute paralytic…”
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Pulmonary delivery of dry powders to rats: Tolerability limits of an intra-tracheal administration model by Guillon, A., Montharu, J., Vecellio, L., Schubnel, V., Roseau, G., Guillemain, J., Diot, P., de Monte, M.

“…The inhaled route is increasingly developed to deliver locally acting or systemic therapies, and rodent models are used to assess tolerance before clinical…”
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Dietary Soy Prevents Alcohol-Mediated Neurocognitive Dysfunction and Associated Impairments in Brain Insulin Pathway Signaling in an Adolescent Rat Model by Tong, Ming, Ziplow, Jason L, Mark, Princess, de la Monte, Suzanne M

“…Alcohol-related brain degeneration is linked to cognitive-motor deficits and impaired signaling through insulin/insulin-like growth factor type 1 (IGF-1)-Akt…”
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Concordant and Discordant Cerebrospinal Fluid and Plasma Cytokine and Chemokine Responses in Mild Cognitive Impairment and Early-Stage Alzheimer's Disease by de la Monte, Suzanne M, Tong, Ming, Hapel, Andrew J

“…Neuroinflammation may be a pathogenic mediator and biomarker of neurodegeneration at the boundary between mild cognitive impairment (MCI) and early-stage…”
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Brain metabolic dysfunction at the core of Alzheimer's disease by de la Monte, Suzanne M., Tong, Ming

“…Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a metabolic disease with molecular and biochemical features that…”
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Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease by de la Monte, Suzanne M, Wands, Jack R

“…Interest in characterizing the role of impaired insulin actions in Alzheimer's disease (AD) and vascular dementia is growing exponentially. This review details…”
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Ethanol inhibits insulin expression and actions in the developing brain by de la Monte, S M, Xu, X J, Wands, J R

“…Ethanol-induced cerebellar hypoplasia is associated with inhibition of insulin-stimulated survival signaling. The present work explores the mechanisms of…”
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Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease by Lester-Coll, Nataniel, Rivera, Enrique J, Soscia, Stephanie J, Doiron, Kathryn, Wands, Jack R, de la Monte, Suzanne M

“…The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent oxidative stress, mitochondrial dysfunction, impaired energy…”
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Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer's Disease (Type 3 Diabetes) by de la Monte, Suzanne M

“…Malignant brain aging corresponds to accelerated age-related declines in brain functions eventually derailing the self-sustaining forces that govern…”
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Mitochondrial DNA Damage as a Mechanism of Cell Loss in Alzheimer's Disease by DE LA MONTE, S. M, TRI LUONG, NEELY, T. R, ROBINSON, D, WANDS, J. R

“…Aging is associated with impaired mitochondrial function caused by accumulation of oxygen free radical-induced mitochondrial (Mt) DNA mutations. One prevailing…”
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Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways by Liou, Connie J., Tong, Ming, Vonsattel, Jean P., de la Monte, Suzanne M.

“…Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology…”
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Conquering Insulin Network Dysfunctions in Alzheimer's Disease: Where Are We Today? by de la Monte, Suzanne M

“…Functional impairments in the brain's insulin and insulin-like growth factor (IGF) signal transduction networks are recognized mediators of dysregulated energy…”
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Alcohol-Induced Disruption of Endocrine Signaling by Ronis, Martin J. J., Wands, Jack R., Badger, Thomas M., De La Monte, Suzanne M., Lang, Charles H., Calissendorff, Jan

“…This article contains the proceedings of a symposium at the 2006 ISBRA Meeting in Sydney Australia, organized and cochaired by Martin J. Ronis and Thomas M…”
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Myriocin Treatment Reverses Alcohol-Induced Alterations in Polyunsaturated Fatty Acid-Containing Phospholipid Expression in the Liver by Yalcin, Emine B, Tong, Ming, Homans, Camilla, de la Monte, Suzanne M

“…Chronic heavy alcohol exposure causes steatohepatitis manifested by abnormal intra-hepatocyte accumulation of lipid and parenchymal inflammation. Attendant…”
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Acetaldehyde adducts in alcoholic liver disease by Setshedi, Mashiko, Wands, Jack R, Monte, Suzanne M de la

“…Chronic alcohol abuse causes liver disease that progresses from simple steatosis through stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic…”
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