Search Results - "de Moerloose, Barbara"

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia by Hofmans, Mattias, Lammens, Tim, Depreter, Barbara, Wu, Ying, Erlacher, Miriam, Caye, Aurélie, Cavé, Hélène, Flotho, Christian, de Haas, Valerie, Niemeyer, Charlotte M., Stary, Jan, Van Nieuwerburgh, Filip, Deforce, Dieter, Van Loocke, Wouter, Van Vlierberghe, Pieter, Philippé, Jan, De Moerloose, Barbara

“…Juvenile myelomonocytic leukemia (JMML) treatment primarily relies on hematopoietic stem cell transplantation and results in long-term overall survival of…”
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Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes by Sahoo, Sushree S., Pastor, Victor B., Goodings, Charnise, Voss, Rebecca K., Kozyra, Emilia J., Szvetnik, Amina, Noellke, Peter, Dworzak, Michael, Starý, Jan, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, De Moerloose, Barbara, Catala, Albert, Kállay, Krisztián, Turkiewicz, Dominik, Hasle, Henrik, Buechner, Jochen, Jahnukainen, Kirsi, Ussowicz, Marek, Polychronopoulou, Sophia, Smith, Owen P., Fabri, Oksana, Barzilai, Shlomit, de Haas, Valerie, Baumann, Irith, Schwarz-Furlan, Stephan, Niewisch, Marena R., Sauer, Martin G., Burkhardt, Birgit, Lang, Peter, Bader, Peter, Beier, Rita, Müller, Ingo, Albert, Michael H., Meisel, Roland, Schulz, Ansgar, Cario, Gunnar, Panda, Pritam K., Wehrle, Julius, Hirabayashi, Shinsuke, Derecka, Marta, Durruthy-Durruthy, Robert, Göhring, Gudrun, Yoshimi-Noellke, Ayami, Ku, Manching, Lebrecht, Dirk, Erlacher, Miriam, Flotho, Christian, Strahm, Brigitte, Niemeyer, Charlotte M., Wlodarski, Marcin W.

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Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia by Vanhooren, Jolien, Van Camp, Laurens, Depreter, Barbara, de Jong, Martijn, Uyttebroeck, Anne, Van Damme, An, Dedeken, Laurence, Dresse, Marie-Françoise, van der Werff Ten Bosch, Jutte, Hofmans, Mattias, Philippé, Jan, De Moerloose, Barbara, Lammens, Tim

“…Pediatric acute myeloid leukemia (pedAML) is a heterogeneous blood cancer that affects children. Although survival rates have significantly improved over the…”
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PATHWAY-DIRECTED THERAPY APPROACH IN PEDIATRIC MDS AND AML by De Moerloose, Barbara

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Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia by Orlando, Elena J., Han, Xia, Tribouley, Catherine, Wood, Patricia A., Leary, Rebecca J., Riester, Markus, Levine, John E., Qayed, Muna, Grupp, Stephan A., Boyer, Michael, De Moerloose, Barbara, Nemecek, Eneida R., Bittencourt, Henrique, Hiramatsu, Hidefumi, Buechner, Jochen, Davies, Stella M., Verneris, Michael R., Nguyen, Kevin, Brogdon, Jennifer L., Bitter, Hans, Morrissey, Michael, Pierog, Piotr, Pantano, Serafino, Engelman, Jeffrey A., Winckler, Wendy

“…We identified genetic mutations in CD19 and loss of heterozygosity at the time of CD19 – relapse to chimeric antigen receptor (CAR) therapy. The mutations are…”
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Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents by Wlodarski, Marcin W., Hirabayashi, Shinsuke, Pastor, Victor, Starý, Jan, Hasle, Henrik, Masetti, Riccardo, Dworzak, Michael, Schmugge, Markus, van den Heuvel-Eibrink, Marry, Ussowicz, Marek, De Moerloose, Barbara, Catala, Albert, Smith, Owen P., Sedlacek, Petr, Lankester, Arjan C., Zecca, Marco, Bordon, Victoria, Matthes-Martin, Susanne, Abrahamsson, Jonas, Kühl, Jörn Sven, Sykora, Karl-Walter, Albert, Michael H., Przychodzien, Bartlomiej, Maciejewski, Jaroslaw P., Schwarz, Stephan, Göhring, Gudrun, Schlegelberger, Brigitte, Cseh, Annámaria, Noellke, Peter, Yoshimi, Ayami, Locatelli, Franco, Baumann, Irith, Strahm, Brigitte, Niemeyer, Charlotte M.

“…Germline GATA2 mutations cause cellular deficiencies with high propensity for myeloid disease. We investigated 426 children and adolescents with primary…”
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Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes by Sahoo, Sushree S., Pastor, Victor B., Goodings, Charnise, Voss, Rebecca K., Kozyra, Emilia J., Szvetnik, Amina, Noellke, Peter, Dworzak, Michael, Starý, Jan, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, De Moerloose, Barbara, Catala, Albert, Kállay, Krisztián, Turkiewicz, Dominik, Hasle, Henrik, Buechner, Jochen, Jahnukainen, Kirsi, Ussowicz, Marek, Polychronopoulou, Sophia, Smith, Owen P., Fabri, Oksana, Barzilai, Shlomit, de Haas, Valerie, Baumann, Irith, Schwarz-Furlan, Stephan, Niewisch, Marena R., Sauer, Martin G., Burkhardt, Birgit, Lang, Peter, Bader, Peter, Beier, Rita, Müller, Ingo, Albert, Michael H., Meisel, Roland, Schulz, Ansgar, Cario, Gunnar, Panda, Pritam K., Wehrle, Julius, Hirabayashi, Shinsuke, Derecka, Marta, Durruthy-Durruthy, Robert, Göhring, Gudrun, Yoshimi-Noellke, Ayami, Ku, Manching, Lebrecht, Dirk, Erlacher, Miriam, Flotho, Christian, Strahm, Brigitte, Niemeyer, Charlotte M., Wlodarski, Marcin W.

“…Germline SAMD9 and SAMD9L mutations ( SAMD9/9L mut ) predispose to myelodysplastic syndromes (MDS) with propensity for somatic rescue. In this study, we…”
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Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia by Zwaan, C Michel, Kolb, Edward A, Reinhardt, Dirk, Abrahamsson, Jonas, Adachi, Souichi, Aplenc, Richard, De Bont, Eveline S J M, De Moerloose, Barbara, Dworzak, Michael, Gibson, Brenda E S, Hasle, Henrik, Leverger, Guy, Locatelli, Franco, Ragu, Christine, Ribeiro, Raul C, Rizzari, Carmelo, Rubnitz, Jeffrey E, Smith, Owen P, Sung, Lillian, Tomizawa, Daisuke, van den Heuvel-Eibrink, Marry M, Creutzig, Ursula, Kaspers, Gertjan J L

“…Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid leukemia (AML) have made enormous progress during the past decades. Because…”
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A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo by Nguyen, Hien Anh, Su, Ying, Zhang, Jenny Y, Antanasijevic, Aleksandar, Caffrey, Michael, Schalk, Amanda M, Liu, Li, Rondelli, Damiano, Oh, Annie, Mahmud, Dolores L, Bosland, Maarten C, Kajdacsy-Balla, Andre, Peirs, Sofie, Lammens, Tim, Mondelaers, Veerle, De Moerloose, Barbara, Goossens, Steven, Schlicht, Michael J, Kabirov, Kasim K, Lyubimov, Alexander V, Merrill, Bradley J, Saunthararajah, Yogen, Van Vlierberghe, Pieter, Lavie, Arnon

“…Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug…”
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RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia by Lipka, Daniel B., Witte, Tania, Toth, Reka, Yang, Jing, Wiesenfarth, Manuel, Nöllke, Peter, Fischer, Alexandra, Brocks, David, Gu, Zuguang, Park, Jeongbin, Strahm, Brigitte, Wlodarski, Marcin, Yoshimi, Ayami, Claus, Rainer, Lübbert, Michael, Busch, Hauke, Boerries, Melanie, Hartmann, Mark, Schönung, Maximilian, Kilik, Umut, Langstein, Jens, Wierzbinska, Justyna A., Pabst, Caroline, Garg, Swati, Catalá, Albert, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Locatelli, Franco, Masetti, Riccardo, Schmugge, Markus, Smith, Owen, Stary, Jan, Ussowicz, Marek, van den Heuvel-Eibrink, Marry M., Assenov, Yassen, Schlesner, Matthias, Niemeyer, Charlotte, Flotho, Christian, Plass, Christoph

“…Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative disorder of early childhood characterized by mutations activating RAS signaling…”
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TARP as antigen in cancer immunotherapy by Vanhooren, Jolien, Derpoorter, Charlotte, Depreter, Barbara, Deneweth, Larissa, Philippé, Jan, De Moerloose, Barbara, Lammens, Tim

“…In recent decades, immunotherapy has become a pivotal element in cancer treatment. A remaining challenge is the identification of cancer-associated antigens…”
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Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13) by Östlund, Anders, Waraky, Ahmed, Staffas, Anna, Sjögren, Helene, De Moerloose, Barbara, Arad‐Cohen, Nira, Cheuk, Daniel, Navarro, Jose Maria Fernandez, Jahnukainen, Kirsi, Kaspers, Gertjan J. L., Kovalova, Zhanna, Pasauliene, Ramune, Saks, Kadri, Zeller, Bernward, Norén‐Nyström, Ulrika, Hasle, Henrik, Fogelstrand, Linda, Abrahamsson, Jonas, Palmqvist, Lars

“…ABSTRACT Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is a recurrent translocation in AML in infants or very young children and was recently included in…”
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Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndrome by Bortnick, Rachel, Wlodarski, Marcin, de Haas, Valerie, De Moerloose, Barbara, Dworzak, Michael, Hasle, Henrik, Masetti, Riccardo, Starý, Jan, Turkiewicz, Dominik, Ussowicz, Marek, Kozyra, Emilia, Albert, Michael, Bader, Peter, Bordon, Victoria, Cario, Gunnar, Beier, Rita, Schulte, Johannes, Bresters, Dorine, Müller, Ingo, Pichler, Herbert, Sedlacek, Petr, Sauer, Martin G., Zecca, Marco, Göhring, Gudrun, Yoshimi, Ayami, Noellke, Peter, Erlacher, Miriam, Locatelli, Franco, Niemeyer, Charlotte M., Strahm, Brigitte

“…GATA2 deficiency is a heterogeneous multi-system disorder characterized by a high risk of developing myelodysplastic syndrome (MDS) and myeloid leukemia. We…”
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Synonymous GATA2 mutations result in selective loss of mutated RNA and are common in patients with GATA2 deficiency by Kozyra, Emilia J., Pastor, Victor B., Lefkopoulos, Stylianos, Sahoo, Sushree S., Busch, Hauke, Voss, Rebecca K., Erlacher, Miriam, Lebrecht, Dirk, Szvetnik, Enikoe A., Hirabayashi, Shinsuke, Pasaulienė, Ramunė, Pedace, Lucia, Tartaglia, Marco, Klemann, Christian, Metzger, Patrick, Boerries, Melanie, Catala, Albert, Hasle, Henrik, de Haas, Valerie, Kállay, Krisztián, Masetti, Riccardo, De Moerloose, Barbara, Dworzak, Michael, Schmugge, Markus, Smith, Owen, Starý, Jan, Mejstrikova, Ester, Ussowicz, Marek, Morris, Emma, Singh, Preeti, Collin, Matthew, Derecka, Marta, Göhring, Gudrun, Flotho, Christian, Strahm, Brigitte, Locatelli, Franco, Niemeyer, Charlotte M., Trompouki, Eirini, Wlodarski, Marcin W.

“…Deficiency of the transcription factor GATA2 is a highly penetrant genetic disorder predisposing to myelodysplastic syndromes (MDS) and immunodeficiency. It…”
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In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia by Van Trimpont, Maaike, Schalk, Amanda M, De Visser, Yanti, Nguyen, Hien Anh, Reunes, Lindy, Vandemeulebroecke, Katrien, Peeters, Evelien, Su, Ying, Lee, Hyun, Lorenzi, Philip L, Chan, Wai-Kin, Mondelaers, Veerle, De Moerloose, Barbara, Lammens, Tim, Goossens, Steven, Van Vlierberghe, Pieter, Lavie, Arnon

“…Asparagine is a non-essential amino acid since it can either be taken up via the diet or synthesized by asparagine synthetase. Acute lymphoblastic leukemia…”
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Prognostic discrimination based on the EUTOS long-term survival score within the International Registry for Chronic Myeloid Leukemia in children and adolescents by Millot, Frédéric, Guilhot, Joëlle, Suttorp, Meinolf, Güneş, Adalet Meral, Sedlacek, Petr, De Bont, Eveline, Li, Chi Kong, Kalwak, Krzysztof, Lausen, Birgitte, Culic, Srdjana, Dworzak, Michael, Kaiserova, Emilia, De Moerloose, Barbara, Roula, Farah, Biondi, Andrea, Baruchel, André

“…The EUTOS Long-Term Survival score was tested in 350 children with chronic myeloid leukemia in first chronic phase treated with imatinib and registered in the…”
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Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia by Karlsson, Lene, Cheuk, Daniel, De Moerloose, Barbara, Hasle, Henrik, Jahnukainen, Kirsi, Juul‐Dam, Kristian Løvvik, Kaspers, Gertjan, Kovalova, Zanna, Lausen, Birgitte, Nyström, Ulrika Norén, Palle, Josefine, Pronk, Cornelis Jan, Saks, Kadri, Tierens, Anne, Zeller, Bernward, Abrahamsson, Jonas

“…Summary A significant proportion of events in paediatric acute myeloid leukaemia (AML) are caused by resistant disease (RD). We investigated clinical and…”
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Deciphering molecular heterogeneity in pediatric AML using a cancer vs. normal transcriptomic approach by Depreter, Barbara, De Moerloose, Barbara, Vandepoele, Karl, Uyttebroeck, Anne, Van Damme, An, Terras, Eva, Denys, Barbara, Dedeken, Laurence, Dresse, Marie-Françoise, Van der Werff Ten Bosch, Jutte, Hofmans, Mattias, Philippé, Jan, Lammens, Tim

“…Background Still 30–40% of pediatric acute myeloid leukemia (pedAML) patients relapse. Delineation of the transcriptomic profile of leukemic subpopulations…”
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THE CLINICAL SPECTRUM AND BIOLOGICAL FINDINGS IN RAS-ASSOCIATED JUVENILE MYELOMONOCYTIC LEUKEMIA AND RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER by Verhulst, Hanne, Camp, Laurens Van, Hofmans, Mattias, Moerloose, Barbara De

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Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study by Inaba, Hiroto, Zhou, Yinmei, Abla, Oussama, Adachi, Souichi, Auvrignon, Anne, Beverloo, H. Berna, de Bont, Eveline, Chang, Tai-Tsung, Creutzig, Ursula, Dworzak, Michael, Elitzur, Sarah, Fynn, Alcira, Forestier, Erik, Hasle, Henrik, Liang, Der-Cherng, Lee, Vincent, Locatelli, Franco, Masetti, Riccardo, De Moerloose, Barbara, Reinhardt, Dirk, Rodriguez, Laura, Van Roy, Nadine, Shen, Shuhong, Taga, Takashi, Tomizawa, Daisuke, Yeoh, Allen E.J., Zimmermann, Martin, Raimondi, Susana C.

“…Comprehensive clinical studies of patients with acute megakaryoblastic leukemia (AMKL) are lacking. We performed an international retrospective study on 490…”
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