Search Results - "de Miranda, Noel F"

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4 by van den Bulk, Jitske, Verdegaal, Els M E, Ruano, Dina, Ijsselsteijn, Marieke E, Visser, Marten, van der Breggen, Ruud, Duhen, Thomas, van der Ploeg, Manon, de Vries, Natasja L, Oosting, Jan, Peeters, Koen C M J, Weinberg, Andrew D, Farina-Sarasqueta, Arantza, van der Burg, Sjoerd H, de Miranda, Noel F C C

“…The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch…”
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PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors by Beyrend, Guillaume, van der Gracht, Esmé, Yilmaz, Ayse, van Duikeren, Suzanne, Camps, Marcel, Höllt, Thomas, Vilanova, Anna, van Unen, Vincent, Koning, Frits, de Miranda, Noel F C C, Arens, Ramon, Ossendorp, Ferry

“…The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of…”
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Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients by Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E, de Miranda, Noel F C C, Lelieveldt, Boudewijn P F, Dijkstra, Jouke, van Roon-Mom, Willeke M C, Höllt, Thomas, van der Weerd, Louise

“…Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown…”
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Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors by Duhen, Thomas, Duhen, Rebekka, Montler, Ryan, Moses, Jake, Moudgil, Tarsem, de Miranda, Noel F., Goodall, Cheri P., Blair, Tiffany C., Fox, Bernard A., McDermott, Jason E., Chang, Shu-Ching, Grunkemeier, Gary, Leidner, Rom, Bell, Richard Bryan, Weinberg, Andrew D.

“…Identifying tumor antigen-specific T cells from cancer patients has important implications for immunotherapy diagnostics and therapeutics. Here, we show that…”
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Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation by Guo, Nannan, Li, Na, Jia, Li, Jiang, Qinyue, Schreurs, Mette, van Unen, Vincent, de Sousa Lopes, Susana M. Chuva, Vloemans, Alexandra A., Eggermont, Jeroen, Lelieveldt, Boudewijn, Staal, Frank J. T., de Miranda, Noel F. C. C., Pascutti, M. Fernanda, Koning, Frits

“…The intestine represents the largest immune compartment in the human body, yet its development and organisation during human foetal development is largely…”
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Germline variant affecting p53β isoforms predisposes to familial cancer by Schubert, Stephanie A., Ruano, Dina, Joruiz, Sebastien M., Stroosma, Jordy, Glavak, Nikolina, Montali, Anna, Pinto, Lia M., Rodríguez-Girondo, Mar, Barge-Schaapveld, Daniela Q. C. M., Nielsen, Maartje, van Nesselrooij, Bernadette P. M., Mensenkamp, Arjen R., van Leerdam, Monique E., Sharp, Thomas H., Morreau, Hans, Bourdon, Jean-Christophe, de Miranda, Noel F. C. C., van Wezel, Tom

“…Germline and somatic TP53 variants play a crucial role during tumorigenesis. However, genetic variations that solely affect the alternatively spliced p53…”
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The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis by Meijer, Debora M., Ruano, Dina, Briaire‐de Bruijn, Inge H., Wijers‐Koster, Pauline M., Sande, Michiel A. J., Gelderblom, Hans, Cleton‐Jansen, Anne‐Marie, Miranda, Noel F. C. C., Kuijjer, Marieke L., Bovée, Judith V. M. G.

“…ABSTRACT Osteosarcoma is a primary bone tumor that exhibits a complex genomic landscape characterized by gross chromosomal abnormalities. Osteosarcoma patients…”
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The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer by Trimaglio, Giulia, Sneperger, Tamara, Raymond, Benjamin B. A., Gilles, Nelly, Näser, Emmanuelle, Locard-Paulet, Marie, Ijsselsteijn, Marieke E., Brouwer, Thomas P., Ecalard, Romain, Roelands, Jessica, Matsumoto, Naoki, Colom, André, Habch, Myriam, de Miranda, Noel F. C. C., Vergnolle, Nathalie, Devaud, Christel, Neyrolles, Olivier, Rombouts, Yoann

“…Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the…”
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Advancing cancer immunotherapy: a vision for the field by de Miranda, Noel F C C, Trajanoski, Zlatko

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Advancing multiplexed imaging for enhanced tissue complexity analysis by Ijsselsteijn, Marieke E., de Miranda, Noel F. C. C.

“…Multiplexed spatial immunophenotyping has advanced our understanding of tissues in the context of homeostasis and disease. Two studies now provide additional…”
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Memory CD4+ T cells are generated in the human fetal intestine by Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P. F., Koning, Frits

“…The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO + T cells reside in the fetal intestine. Here we combined functional assays…”
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Integration of mass cytometry and mass spectrometry imaging for spatially resolved single-cell metabolic profiling by Nunes, Joana B., Ijsselsteijn, Marieke E., Abdelaal, Tamim, Ursem, Rick, van der Ploeg, Manon, Giera, Martin, Everts, Bart, Mahfouz, Ahmed, Heijs, Bram, de Miranda, Noel F. C. C.

“…The integration of spatial omics technologies can provide important insights into the biology of tissues. Here we combined mass spectrometry imaging-based…”
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Mass Cytometric Analysis of Early-Stage Mycosis Fungoides by Guo, Nannan, Jia, Li, Out-Luiting, Coby, Miranda, Noel F C C de, Willemze, Rein, Koning, Frits, Vermeer, Maarten, Quint, Koen

“…Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. Early-stage disease is characterized by superficial infiltrates of small- to…”
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Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial by Verschoor, Yara L., van de Haar, Joris, van den Berg, José G., van Sandick, Johanna W., Kodach, Liudmila L., van Dieren, Jolanda M., Balduzzi, Sara, Grootscholten, Cecile, IJsselsteijn, Marieke E., Veenhof, Alexander A. F. A., Hartemink, Koen J., Vollebergh, Marieke A., Jurdi, Adham, Sharma, Shruti, Spickard, Erik, Owers, Emilia C., Bartels-Rutten, Annemarieke, den Hartog, Peggy, de Miranda, Noel F. C. C., van Leerdam, Monique E., Haanen, John B. A. G., Schumacher, Ton N., Voest, Emile E., Chalabi, Myriam

“…Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite recent advancements, most patients die of their disease. Although…”
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Germline NPAT inactivating variants as cause of hereditary colorectal cancer by Terradas, Mariona, Schubert, Stephanie A, Viana-Errasti, Julen, Ruano, Dina, Aiza, Gemma, Nielsen, Maartje, Marciel, Paula, Tops, Carli M, Parra, Genís, Morreau, Hans, Torrents, David, van Leerdam, Monique E, Capellá, Gabriel, de Miranda, Noel F C C, Valle, Laura, van Wezel, Tom

“…Two independent exome sequencing initiatives aimed to identify new genes involved in the predisposition to nonpolyposis colorectal cancer led to the…”
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Author Correction: Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial by Verschoor, Yara L., van de Haar, Joris, van den Berg, José G., van Sandick, Johanna W., Kodach, Liudmila L., van Dieren, Jolanda M., Balduzzi, Sara, Grootscholten, Cecile, IJsselsteijn, Marieke E., Veenhof, Alexander A. F. A., Hartemink, Koen J., Vollebergh, Marieke A., Jurdi, Adham, Sharma, Shruti, Spickard, Erik, Owers, Emilia C., Bartels-Rutten, Annemarieke, den Hartog, Peggy, de Miranda, Noel F. C. C., van Leerdam, Monique E., Haanen, John B. A. G., Schumacher, Ton N., Voest, Emile E., Chalabi, Myriam

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Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model by Kumar, Sumit, Schoonderwoerd, Mark J A, Kroonen, Jessie S, de Graaf, Ilona J, Sluijter, Marjolein, Ruano, Dina, González-Prieto, Román, Verlaan-de Vries, Matty, Rip, Jasper, Arens, Ramon, de Miranda, Noel F C C, Hawinkels, Lukas J A C, van Hall, Thorbald, Vertegaal, Alfred C O

“…Pancreatic ductal adenocarcinoma (PDAC) has the characteristics of high-density desmoplastic stroma, a distinctive immunosuppressive microenvironment and is…”
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High-dimensional cytometric analysis of colorectal cancer reveals novel mediators of antitumour immunity by de Vries, Natasja L, van Unen, Vincent, Ijsselsteijn, Marieke E, Abdelaal, Tamim, van der Breggen, Ruud, Farina Sarasqueta, Arantza, Mahfouz, Ahmed, Peeters, Koen C M J, Höllt, Thomas, Lelieveldt, Boudewijn P F, Koning, Frits, de Miranda, Noel F C C

“…A comprehensive understanding of anticancer immune responses is paramount for the optimal application and development of cancer immunotherapies. We unravelled…”
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Immunotherapy for pancreatic cancer: chasing the light at the end of the tunnel by Brouwer, Thomas P., Vahrmeijer, Alexander L., de Miranda, Noel F. C. C.

“…Background Checkpoint blockade immunotherapy has had a significant impact on the survival of a subset of patients with advanced cancers. It has been…”
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Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis by Roelands, Jessica, van der Ploeg, Manon, Ijsselsteijn, Marieke E, Dang, Hao, Boonstra, Jurjen J, Hardwick, James C H, Hawinkels, Lukas J A C, Morreau, Hans, de Miranda, Noel F C C

“…Biological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early detection…”
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