Solitary giant neurofibroma of the mental nerve: a trauma-related lesion?

Neurofibroma is a benign neoplasm derived from peripheral nerves whose etiology is still unclear. It may present as a solitary lesion or be associated with other diseases such as neurofibromatosis type I and II syndrome. This paper aims to report an extremely rare case of a solitary giant neurofibro...

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Bibliographic Details
Published in:	The Journal of craniofacial surgery Vol. 24; no. 3; pp. e247 - e251
Main Authors:	da Rosa, Marina R P, Ribeiro, André Luis Ribeiro, de Menezes, Sílvio A F, Pinheiro, João J V, Alves-Junior, Sérgio M
Format:	Journal Article
Language:	English
Published:	United States 01-05-2013
Subjects:	Adolescent Cell Nucleus - pathology Chin - injuries Chin - innervation Connective Tissue - pathology Cranial Nerve Neoplasms - diagnosis Cranial Nerve Neoplasms - etiology Cytoplasm - pathology Dentistry Facial Injuries - complications Female Follow-Up Studies Humans Mandibular Nerve - pathology Neurofibroma - diagnosis Neurofibroma - etiology S100 Proteins - analysis Soft Tissue Injuries - complications Vimentin - analysis
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Summary:	Neurofibroma is a benign neoplasm derived from peripheral nerves whose etiology is still unclear. It may present as a solitary lesion or be associated with other diseases such as neurofibromatosis type I and II syndrome. This paper aims to report an extremely rare case of a solitary giant neurofibroma of the mental nerve whose etiology was related to a local trauma. A 14-year-old female patient presented an extensive left facial mass with a size of 7 × 5 × 4 cm, located between the teeth 33 and 37 in the mandible region. It has begun to grow 3 months after a local trauma. Imaging studies were suggestive of a soft-tissue lesion, with minimal bone changes and maintaining the integrity of the mandibular canal and mental foramen. Histopathological tests showed spindle cells with undulated and hyperchromatic nuclei, and sparse cytoplasm in a stroma composed of dense fibrous connective tissue. Immunohistochemistry revealed positive expression for the proteins S-100 and vimentin, confirming the diagnosis of neurofibroma. The patient underwent surgical removal of the lesion by intraoral approach and evolved with an excellent cosmetic result and no signs of recurrence after 2 years of follow up. We report a rare case of solitary giant neurofibroma whose etiology was related to a local trauma. To our knowledge, this is the first report of a mental nerve neurofibroma. Although the etiology remains unclear, we suggest the investigation of local trauma as a possible etiologic factor for solitary neurofibromas of the jaw.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1049-2275 1536-3732
DOI:	10.1097/SCS.0b013e3182869f03