Search Results - "de Melo Rodrigues Avila, Veridiana"
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Antimicrobial effect of bothropstoxin-i in broilers
Published in Semina. Ciências agrárias : revista cultural e científica da Universidade Estadual de Londrina (01-01-2021)“…Bacterial resistance is a sanitary issue explained by indiscriminate use of nonprescription drugs, and antimicrobial use in food production for growth…”
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2
Inhibition of Triple-Negative Breast Cancer Cell Aggressiveness by Cathepsin D Blockage: Role of Annexin A1
Published in International journal of molecular sciences (16-03-2019)“…Triple-negative breast cancers (TNBCs) are more aggressive than other breast cancer (BC) subtypes and lack effective therapeutic options. Unraveling marker…”
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3
In vitro and in vivo antitumor effect of trachylobane-360, a diterpene from Xylopia langsdorffiana
Published in Molecules (Basel, Switzerland) (10-08-2012)“…Trachylobane-360 (ent-7α-acetoxytrachyloban-18-oic acid) was isolated from Xylopia langsdorffiana. Studies have shown that it has weak cytotoxic activity…”
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4
Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle
Published in Chembiochem : a European journal of chemical biology (16-09-2019)“…Class 1 myosins (Myo1s) were the first unconventional myosins identified and humans have eight known Myo1 isoforms. The Myo1 family is involved in the…”
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5
BjussuLAAO-II, an l-amino acid oxidase from Bothrops jararacussu snake venom, impairs Toxoplasma gondii infection in human trophoblast cells and villous explants from the third trimester of pregnancy
Published in Microbes and infection (01-07-2023)“…One-third of the world's population is estimated to be affected by toxoplasmosis. Pregnancy-related Toxoplasma gondii infection can cause vertical…”
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6
A 20-hydroxyecdysone-enriched fraction from Pfaffia glomerata (Spreng.) pedersen roots alleviates stress, anxiety, and depression in mice
Published in Journal of ethnopharmacology (01-03-2021)“…Pfaffia glomerata roots are widely used in Brazil to treat various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a…”
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7
Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the cellular invasion process in vitro
Published in Cellular signalling (01-09-2023)“…Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to promote their malignant phenotype. In this framework, we hypothesized…”
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8
PLA2-MjTX-II from Bothrops moojeni snake venom exhibits antimetastatic and antiangiogenic effects on human lung cancer cells
Published in Toxicon (Oxford) (28-05-2024)“…Phospholipases A2 (PLA2s) from snake venom possess antitumor and antiangiogenic properties. In this study, we evaluated the antimetastatic and antiangiogenic…”
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9
Bothrops snake venom L-amino acid oxidases impair biofilm formation of clinically relevant bacteria
Published in Toxicon (Oxford) (01-02-2024)“…The present work addressed the abilities of two L-amino acid oxidases isolated from Bothrops moojeni (BmooLAAO-I) and Bothrops jararacussu (BjussuLAAO-II)…”
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10
Biochemical characterization and assessment of leishmanicidal effects of a new L-amino acid oxidase from Crotalus durissus collilineatus snake venom (CollinLA AO-I)
Published in Toxicon (Oxford) (01-07-2023)“…This study reports the isolation of CollinLAAO-I, a new L-amino acid oxidase from Crotalus durissus collilineatus snake venom, its biochemical characterization…”
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11
Stephalagine, an aporphinic alkaloid with therapeutic effects in acute gout arthritis in mice
Published in Journal of ethnopharmacology (15-07-2022)“…Gout is an inflammatory disease characterized by the accumulation of monosodium urate crystals (MSU) in the joints, leading to severe pain and inflammation…”
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12
Angiotensin type 2 receptor antagonism as a new target to manage gout
Published in Inflammopharmacology (01-12-2022)“…Background There is a growing search for therapeutic targets in the treatment of gout. The present study aimed to evaluate the analgesic and anti-inflammatory…”
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13
Stephalagine, an aporphine alkaloid from Annona crassiflora fruit peel, induces antinociceptive effects by TRPA1 and TRPV1 channels modulation in mice
Published in Bioorganic chemistry (01-03-2020)“…[Display omitted] •A. crassiflora fruit peel extracts reduced formalin-induced nociception.•Stephalagine from A. crassiflora fruit peel reduced nociception and…”
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14
Protective effects of a polyphenol-enriched fraction of the fruit peel of Annona crassiflora Mart. on acute and persistent inflammatory pain
Published in Inflammopharmacology (01-06-2020)“…Different parts of Annona crassiflora Mart., a native species from Brazilian savanna, were traditionally used for the treatment of a wide variety of ailments…”
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15
Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy
Published in Scientific reports (21-03-2017)“…Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan Trypanosoma cruzi ; it…”
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16
Galectin-3: A Friend but Not a Foe during Trypanosoma cruzi Experimental Infection
Published in Frontiers in cellular and infection microbiology (03-11-2017)“…interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins…”
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17
Analysis in vivo of antitumor activity, Cytotoxicity and Interaction between plasmid DNA and the cis-dichlorotetraammineruthenium(III) chloride
Published in Chemico-biological interactions (25-04-2007)“…Several metallic compounds recognized as potent antitumor agents, have been developed and tested in vivo and in vitro. In this work, we evaluated the toxic,…”
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18
Phospholipase A2 Drives Tumorigenesis and Cancer Aggressiveness through Its Interaction with Annexin A1
Published in Cells (Basel, Switzerland) (11-06-2021)“…Phospholipids are suggested to drive tumorigenesis through their essential role in inflammation. Phospholipase A2 (PLA2) is a phospholipid metabolizing enzyme…”
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19
Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death
Published in Biomedicine & pharmacotherapy (01-04-2019)“…[Display omitted] •The copper(II) complex (CBP-01) showed low cytotoxicity (IC50 = 26.4 μM) to murine myoblast (C2C12), a non-tumorigenic cell line.•CBP-01…”
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20
A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA2-Asp-49 from Bothrops jararacussu Venom
Published in Biomolecules (Basel, Switzerland) (04-02-2022)“…Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living organisms, with a broad spectrum of pharmacological activities and…”
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