Effect of Euterpe oleracea Mart. Seeds Extract on Chronic Ischemic Renal Injury in Renovascular Hypertensive Rats

Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of açaí (ASE) fruits in two-kidney, one-c...

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Bibliographic Details
Published in:	Journal of medicinal food Vol. 20; no. 10; p. 1002
Main Authors:	da Costa, Cristiane Aguiar, Ognibene, Dayane Teixeira, Cordeiro, Viviane Silva Cristino, de Bem, Graziele Freitas, Santos, Izabelle Barcellos, Soares, Ricardo Andrade, de Melo Cunha, Letícia L, Carvalho, Lenize C R M, de Moura, Roberto Soares, Resende, Angela Castro
Format:	Journal Article
Language:	English
Published:	United States 01-10-2017
Subjects:	Animals Antihypertensive Agents - administration & dosage Blood Pressure - drug effects Catalase - metabolism Euterpe - chemistry Humans Hypertension, Renovascular - drug therapy Hypertension, Renovascular - metabolism Hypertension, Renovascular - physiopathology Kidney - blood supply Kidney - injuries Kidney - metabolism Kidney - physiopathology Male Oxidative Stress - drug effects Plant Extracts - administration & dosage Rats Rats, Wistar Seeds - chemistry Superoxide Dismutase - metabolism açaí hypertension oxidative stress 2K1C rats renal injury
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Summary:	Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of açaí (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200 mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status. The increase in systolic blood pressure of the 2K1C group was accompanied by a decrease in left kidney volume and number of glomeruli, as well as an increase in glomerular volume and collagen deposition. ASE prevented the alterations of these parameters, except the reduced kidney volume. Serum levels of urea and creatinine and urinary protein excretion were increased in the 2K1C group and treatment with ASE improved all these functional parameters. The increased oxidative damage in the 2K1C group, assessed by lipid and protein oxidation, was prevented by ASE. The nitrite content and both expression and activity of antioxidant enzymes (superoxide dismutase-1, catalase, and glutathione peroxidase) were lower in the 2K1C group and restored by ASE. ASE substantially reduced renal injury and prevented renal dysfunction in 2K1C rats probably through its antihypertensive and antioxidant effects, providing a natural resource for treatment and prevention of renovascular hypertension-related abnormalities.
ISSN:	1557-7600
DOI:	10.1089/jmf.2017.0011