Search Results - "de Mello, Natalia Prudente"
-
1
Systematic mapping of mitochondrial calcium uniporter channel (MCUC)-mediated calcium signaling networks
Published in The EMBO journal (11-09-2024)“…The mitochondrial calcium uniporter channel (MCUC) mediates mitochondrial calcium entry, regulating energy metabolism and cell death. Although several MCUC…”
Get full text
Journal Article -
2
Inverse sex-based expression profiles of PTEN and Klotho in mice
Published in Scientific reports (19-11-2020)“…Sex differences are considered predictive factors in the development of several neurological diseases, which are also known to coincide with impaired…”
Get full text
Journal Article -
3
Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Published in Biomedicines (15-11-2022)“…Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na /K -ATPase signaling and that can activate tumor…”
Get full text
Journal Article -
4
Insulin and Autophagy in Neurodegeneration
Published in Frontiers in neuroscience (22-05-2019)“…Crosstalk in the pathophysiological processes underpinning metabolic diseases and neurodegenerative disorders have been the subject of extensive investigation,…”
Get full text
Journal Article -
5
Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice
Published in Nature protocols (01-07-2023)“…Mitochondria are key bioenergetic organelles involved in many biosynthetic and signaling pathways. However, their differential contribution to specific…”
Get full text
Journal Article -
6
Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity
Published in Life science alliance (01-08-2024)“…Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue…”
Get full text
Journal Article -
7
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
Published in Nature metabolism (01-08-2023)“…Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common…”
Get full text
Journal Article