Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil

Prevalence and clinical implications of low-risk human papillomavirus among patients with recurrent respiratory papillomatosis in Rio de Janeiro, Brazil

The aim of this study was to investigate the presence of human papillomavirus (HPV) in biopsy specimens from juvenile and adult patients with histopathological diagnosis of recurrent respiratory papillomatosis (RRP) treated in two public hospitals in Rio de Janeiro, Brazil. We performed the detectio...

Full description

Saved in:
Bibliographic Details
Published in:Auris, nasus, larynx Vol. 46; no. 4; pp. 570 - 575
Main Authors: Figueiredo, Marcelo Cardoso, Justino, Mariana Chantre, Delmonico, Lucas, Silvestre, Rafaele Tavares, de Castro, Thiago Luz, dos Santos Moreira, Aline, Macedo, Jacyara Maria Brito, da Costa Carvalho, Maria da Glória, Scherrer, Luciano, de Medeiros Lima, Daniel José Matos, Alves, Gilda, Ornellas, Maria Helena
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-08-2019
Subjects:
Adolescent
Adult
Brazil - epidemiology
Clinical outcomes
Female
Genotype
Genotyping
Human papillomavirus
Human papillomavirus 11 - genetics
Human papillomavirus 16 - genetics
Human papillomavirus 18 - genetics
Human papillomavirus 6 - genetics
Humans
Laryngeal Diseases - epidemiology
Laryngeal Diseases - virology
Lung Diseases - epidemiology
Lung Diseases - virology
Male
Papillomavirus Infections - epidemiology
Papillomavirus Infections - virology
Polymerase Chain Reaction
Prevalence
Recurrent respiratory papillomatosis
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Retrospective Studies
Risk
RRP severity
Tracheal Diseases - epidemiology
Tracheal Diseases - virology
Brazil
Human papillomavirus
Recurrent respiratory papillomatosis
RRP severity
Genotyping
Clinical outcomes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to investigate the presence of human papillomavirus (HPV) in biopsy specimens from juvenile and adult patients with histopathological diagnosis of recurrent respiratory papillomatosis (RRP) treated in two public hospitals in Rio de Janeiro, Brazil. We performed the detection and genotyping of HPV by PCR technique for the types 6, 11, 16, and 18 in biopsy specimens from 41 RRP patients. The juvenile onset RRP (JoRRP) corresponded to 61% and the adult onset RRP (AoRRP) corresponded to 39% of the study group. Prevalence of males was observed in both the adult (81.3%) and the juvenile (56%) groups. Lesions in the larynx were more frequent in the glottis (46%). Genotyping analysis only revealed patients with HPV-6 (34.1%), HPV-11(17.1%), and co-infection HPV-6 and -11 (48.8%). RRP severity was significantly associated with the JoRRP (p<0.001), with extralaryngeal disease and more surgeries. However, no significant association between RRP severity and HPV types was found. One co-infected patient in the JoRRP died due to the evolution of the disease with lung involvement. These results show the strong association of HPV-6 and/or HPV-11 types with RRP and could complement the diagnosis, prognosis, and therapies for these patients. In addition, the HPV vaccination should be encouraged to prevent the disease.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2018.11.014