Blackberry extract prevents lipopolysaccharide-induced depressive-like behavior in female mice: implications for redox status, inflammation, and brain enzymes

This study evaluated the effects of extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that extract protected against depressive-like behavior induced by LPS. Moreover, the adminis...

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Bibliographic Details
Published in:	Nutritional neuroscience p. 1
Main Authors:	Custódio, Solange Vega, Piccoli, Raphaela Cassol, Goularte, Kelen Cristiane Machado, Simões, William Sanabria, de Mello, Julia Eisenhardt, de Souza, Anita Avila, de Mattos Almeida, Isabella Pompeu, Barschak, Alethéa Gatto, Tavares, Rejane Giacomelli, Stefanello, Francieli Moro, de Aguiar, Mayara Sandrielly Soares, Spanevello, Roselia Maria
Format:	Journal Article
Language:	English
Published:	England 11-06-2024
Subjects:	cerebral cortex Rubus sp antioxidant depression female mice
Online Access:	Get full text
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Summary:	This study evaluated the effects of extract on behavioral and neurochemical parameters in female mice submitted to experimental model of depression induced by lipopolysaccharide (LPS). The results indicated that extract protected against depressive-like behavior induced by LPS. Moreover, the administration of extract was effective in preventing the increase in reactive species and nitrites levels, as well as the decrease in catalase activity induced by LPS in the cerebral cortex. In the serum, the extract was effective in preventing the decrease in catalase activity induced by LPS. Treatment with extract attenuated the increase in acetylcholinesterase activity induced by LPS in the cerebral cortex. Finally, blackberry extract also downregulated IL-1β levels in cerebral cortex. In conclusion, our findings demonstrated that treatment with exerted antidepressant, antioxidant, anticholinesterase and anti-inflammatory effects in a model of depressive - like behavior induced by LPS in female mice. This highlights . as a potential therapeutic agent for individuals with major depressive disorder.
ISSN:	1476-8305
DOI:	10.1080/1028415X.2024.2363570