Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velo...

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Published in:	Hypertension (Dallas, Tex. 1979) Vol. 61; no. 6; pp. 1322 - 1327
Main Authors:	Corden, Ben, Keenan, Niall G, de Marvao, Antonio S.M, Dawes, Timothy J.W, DeCesare, Alain, Diamond, Tamara, Durighel, Giuliana, Hughes, Alun D, Cook, Stuart A, O’Regan, Declan P
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD American Heart Association, Inc 01-06-2013 Lippincott Williams & Wilkins
Subjects:	Adipose Tissue Adiposity - physiology Adolescent Adult Age Factors Aged Aging - physiology Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Arterial hypertension. Arterial hypotension Arterial Pressure - physiology Biological and medical sciences Blood and lymphatic vessels Blood Flow Velocity Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Disease Progression Female Follow-Up Studies Humans Imaging, Three-Dimensional Incidence Magnetic Resonance Imaging, Cine Male Medical sciences Metabolic diseases Middle Aged Obesity Obesity - complications Obesity - epidemiology Obesity - physiopathology Prognosis Prospective Studies Risk Factors United Kingdom - epidemiology Vascular Stiffness - physiology Young Adult Hypertension Obesity Senescence Middle age MRI Ageing Nutrition disorder Cardiovascular disease Nuclear magnetic resonance imaging Fat mass Artery Reduction Association aortic stiffness Blood vessel Medical imagery Aorta Arterial pressure Blood pressure Stiffness Hemodynamics Circulatory system aging Nutritional status blood pressure obesity
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Summary:	Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velocity in the thoracic aorta, an indicator of central arterial stiffness, was measured in 221 volunteers (range, 18–72 years; mean, 40.3±13 years) who had no history of cardiovascular disease using cardiovascular MRI. In univariate analyses, age (r=0.78; P<0.001) and blood pressure (r=0.41; P<0.001) showed a strong positive association with pulse wave velocity. In multivariate analysis, after adjustment for age, sex, and mean arterial blood pressure, elevated body fat% was associated with reduced aortic stiffness until the age of 50 years, thereafter adiposity had an increasingly positive association with aortic stiffness (β=0.16; P<0.001). Body fat% was positively associated with cardiac output when age, sex, height, and absolute lean mass were adjusted for (β=0.23; P=0.002). These findings suggest that the cardiovascular system of young adults may be capable of adapting to the state of obesity and that an adverse association between body fat and aortic stiffness is only apparent in later life.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.113.01177