Outbreaks of Vesicular stomatitis Alagoas virus in horses and cattle in northeastern Brazil

The current article describes outbreaks of vesicular stomatitis (VS) in horses and cattle in Paraiba and Rio Grande do Norte states, northeastern Brazil, between June and August 2013. The reported cases affected 15–20 horses and 6 cattle distributed over 6 small farms in 4 municipalities, but additi...

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Bibliographic Details
Published in:	Journal of veterinary diagnostic investigation Vol. 26; no. 6; pp. 788 - 794
Main Authors:	Cargnelutti, Juliana F., Olinda, Roberio G., Maia, Lisanka A., de Aguiar, Gildeni M. N., Neto, Eldinê G. M., Simões, Sara V. D., de Lima, Tatiane G., Dantas, Antônio F. M., Weiblen, Rudi, Flores, Eduardo F., Riet-Correa, Franklin
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-11-2014
Subjects:	Animals Brazil - epidemiology Cattle Cattle Diseases - diagnosis Cattle Diseases - epidemiology Cattle Diseases - virology Disease Outbreaks - veterinary Female Horse Diseases - diagnosis Horse Diseases - epidemiology Horse Diseases - virology Horses Male Molecular Sequence Data Phosphoproteins - genetics Phosphoproteins - metabolism Phylogeny Reverse Transcriptase Polymerase Chain Reaction - veterinary Sequence Analysis, DNA - veterinary Vesicular Stomatitis - diagnosis Vesicular Stomatitis - epidemiology Vesicular Stomatitis - virology Vesicular stomatitis Indiana virus - classification Vesicular stomatitis Indiana virus - genetics Vesicular stomatitis Indiana virus - isolation & purification Vesiculovirus - classification Vesiculovirus - genetics Vesiculovirus - isolation & purification Viral Proteins - genetics Viral Proteins - metabolism vesicular disease Alagoas Indiana-3
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Summary:	The current article describes outbreaks of vesicular stomatitis (VS) in horses and cattle in Paraiba and Rio Grande do Norte states, northeastern Brazil, between June and August 2013. The reported cases affected 15–20 horses and 6 cattle distributed over 6 small farms in 4 municipalities, but additional data indicated the involvement of a large number of animals on several farms. The disease was characterized by blisters; eruptive lesions in coronary bands, lips, mouth, and muzzle; salivation; claudication and loss of condition. Swollen lower limbs and lips, and ulcerated and erosive areas in the lips and muzzle were observed in some horses. A necrotizing vesiculopustular dermatitis and stomatitis was observed histologically. Vesicular stomatitis virus was isolated from the vesicular fluid of a horse lesion and shown to be serologically related to the VS Indiana serogroup (VSIV) by virus neutralization. Convalescent sera of affected horses and cattle, and from healthy contacts, harbored high levels of neutralizing antibodies against the isolated virus (named VSIV-3 2013SaoBento/ParaibaE). Genomic sequences of VSIV subtype 3 (Vesicular stomatitis Alagoas virus) were amplified by reverse transcription polymerase chain reaction out of clinical specimens from a cow and a horse from different farms. Nucleotide sequencing and phylogenetic analysis of the phosphoprotein gene indicated that the 2 isolates were derived from the same virus and clustered them in VSIV-3, along with VS viruses identified in southeastern and northeastern Brazil in the last decades. Thus, the present report demonstrates the circulation of VSIV-3 in northeastern Brazil and urges for more effective diagnosis and surveillance.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1040-6387 1943-4936
DOI:	10.1177/1040638714553428