Search Results - "de Lima, Denis Pires"

Carbonyl Compounds′ Journey to Amide Bond Formation by Narendar Reddy, Thatikonda, Beatriz, Adilson, Jayathirtha Rao, Vaidya, de Lima, Dênis Pires

“…The formation of amide bonds is one of the most stimulating emerging areas in organic and medicinal chemistry. Amides are recognized as central building blocks…”
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Recent Advances in the Functionalization of Hydrocarbons: Synthesis of Amides and its Derivatives by Reddy, Thatikonda Narendar, de Lima, Dênis Pires

“…The functionalization of hydrocarbons represents an attractive approach for the synthesis of amides. The amide bond is one of the most fascinating functional…”
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Insights of Cannabinoid CBD: The Pharmacological Potential and Heterologous Expression by Pinto, Ingrid Batista, Mantovani, Cynthia, de Borba, Danrley Ramires dos Santos, Salina, Gabriela Beatriz, de Lima, Denis Pires, Beatriz, Adilson

“…In this review, a thorough approach was taken to the therapeutic potential of CBD and the possibilities of heterologous expression for its synthesis…”
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Thiopyrimidine derivatives induce cytotoxicity, cell cycle arrest and oxidative stress in breast cancer 3D-spheroids by Gomes, Giovana Bicudo, Zubieta, Claudia Stutz, Weber, Simone Schneider, de Lima, Dênis Pires, Reddy, Thatikonda Narendar, Guerrero, Ana Tereza Gomes, de Fatima Cepa Matos, Maria, Parisotto, Eduardo Benedetti, Perdomo, Renata Trentin

“…3D-cultured breast cancer cells had shown relative drug resistance as compared to 2D-cultured cells, and it has been suggested as a new in vitro cell-based…”
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Assessment of acute toxicity and cytotoxicity of fluorescent markers produced by cardanol and glycerol, which are industrial waste, to different biological models by Pelizaro, Bruno Ivo, Braga, Felipe Camargo, Crispim, Bruno do Amaral, de Barros, Luiz Guilherme Maiolino Lacerda, Pessatto, Lucas Roberto, Oliveira, Edwin José Torres, Vani, Juliana Miron, de Souza, Antonio Pancrácio, Grisolia, Alexeia Barufatti, Antoniolli-Silva, Andréia Conceição Milan Brochado, de Lima, Dênis Pires, dos Santos Jaques, Jeandre Augusto, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…The amphyphylic triazoanilines recently synthesized 1-(4-(3-aminophenyl)-1H-1,2,3- triazole-1-yl)-3-(3-pentadecylphenoxy)propan-2-ol (1) and…”
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Cardanol: toxicogenetic assessment and its effects when combined with cyclophosphamide by Schneider, Beatriz Ursinos Catelan, Meza, Alisson, Beatriz, Adilson, Pesarini, João Renato, Carvalho, Pamela Castilho de, Mauro, Mariana de Oliveira, Karaziack, Caroline Bilhar, Cunha-Laura, Andréa Luiza, Monreal, Antônio Carlos Duenhas, Matuo, Renata, Lima, Dênis Pires de, Oliveira, Rodrigo Juliano

“…Cardanol is an effective antioxidant and is a compound with antimutagenic and antitumoral activity. Here, we evaluated the genotoxic and mutagenic potential of…”
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Assessment of the toxicogenic effects and cell death potential of the ester (Z)-methyl 4-((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino)-4-oxobut-2-anoate in combination with cisplatin, cyclophosphamide and doxorubicin by Juliano Oliveira, Rodrigo, Pereira, Fabrícia Paniago Ajala Nery, Silveira, Ingridhy Ostaciana Maia Freitas da, Lima, Ricardo Vieira de, Berno, Claudia Rodrigues, Pesarini, João Renato, Antoniolli-Silva, Andréia Conceição Milan Brochado, Monreal, Antônio Carlos Duenhas, Adilson, Beatriz, Lima, Dênis Pires de, Gomes, Roberto da Silva

“…Despite rapid advances in both the early detection and treatment of cancer, the mortality from this disease remains high, which justifies the development of…”
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In vivo chemotherapeutic insight of a novel isocoumarin (3-hexyl-5,7-dimethoxy-isochromen-1-one): Genotoxicity, cell death induction, leukometry and phagocytic evaluation by Araújo, Flávio Henrique Souza de, Figueiredo, Débora Rojas de, Auharek, Sarah Alves, Pesarini, João Renato, Meza, Alisson, Gomes, Roberto da Silva, Monreal, Antônio Carlos Duenhas, Antoniolli-Silva, Andréia Conceição Milan Brochado, Lima, Dênis Pires de, Kassuya, Candida Aparecida Leite, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of…”
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3-Heptylidene-4,6-Dimethoxy-3H-Isobenzofuran-1-One Is Genotoxic, Increases the Frequency of Cell Death, and Potentiates the Effects of Cyclophosphamide and Cisplatin by das Neves, Silvia Cordeiro, de Araújo, Flavio Henrique, Correa, Willian Ayala, Martins, Allana Cristina Faustino, Coelho, Henrique Rodrigues Scherer, Vilela, Marcelo Luiz Brandão, do Nascimento, Valter Aragão, Kassuya, Candida Aparecida Leite, de Lima, Dênis Pires, Beatriz, Adilson, Oliveira, Rodrigo Juliano, Gomes, Roberto da Silva

“…3-heptylidene-4,6-dimethoxy-3H-isobenzofuran-1-one (Phthalide 1) is the precursor of three resorcinol lipids that have been described as potential…”
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The mixture of cashew nut shell liquid and castor oil results in an efficient larvicide against Aedes aegypti that does not alter embryo-fetal development, reproductive performance or DNA integrity by Vani, Juliana Miron, Monreal, Maria Tereza Ferreira Duenhas, Auharek, Sarah Alves, Cunha-Laura, Andréa Luiza, de Arruda, Eduardo José, Lima, Alessandra Ramos, da Silva, Cicera Maria, Antoniolli-Silva, Andréia Conceição Milan Brochado, de Lima, Dênis Pires, Beatriz, Adilson, Oliveira, Rodrigo Juliano

“…Dengue fever, chikungunya fever and Zika virus are epidemics in Brazil that are transmitted by mosquitoes, such as Aedes aegypti or Aedes albopictus. The…”
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Antileishmanial Activity, Toxicity and Mechanism of Action of Complexes of Sodium Usnate with Lanthanide Ions: Eu(III), Sm(III), Gd(III), Nd(III), La(III) and Tb(III) by da Silva, Fernanda, Rizk, Yasmin Silva, das Neves, Amarith Rodrigues, Lourenço, Estela Mariana Guimarães, Ferreira, Alda Maria Teixeira, Monteiro, Melquisedeque Mateus, de Lima, Dênis Pires, Perdomo, Renata Trentin, Bonfá, Iluska Senna, Toffoli-Kadri, Mônica Cristina, Duarte, Adriana Pereira, Nunes, Daniel Mendes, Martines, Marco Antonio Utrera, Piranda, Eliane Mattos, de Arruda, Carla Cardozo Pinto

“…Leishmaniases are neglected diseases with limited therapeutic options. Diffuse cutaneous leishmaniasis can occur in Brazil due to . This study details the…”
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Effects of 3‐Heptyl‐3,4,6‐trimethoxy‐3H‐isobenzofuran‐1‐one alone or/in association with cyclophosphamide on testicular function by Oliveira, Rodrigo Juliano, Cunha‐Laura, Andréa Luiza, Gonçalves, Caroline Amélia, Monreal, Antônio Carlos Duenhas, Costa, Deiler Sampaio, Meza, Alisson, Lima, Dênis Pires, Beatriz, Adilson, Amaral, Ernani Aloysio, Auharek, Sarah Alves

“…Chemotherapy for cancer treatment may result in a temporary or long‐term gonadal damage resulting in subfertility or infertility. Cyclophosphamide (CY) is a…”
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Chemical modifications of a natural xanthone and antimicrobial activity against multidrug resistant Staphylococcus aureus and cytotoxicity against human tumor cell lines by Micheletti, Ana Camila, Honda, Neli Kika, Lima, Dênis Pires de, Beatriz, Adilson, Sant'ana, Maria Rita, Carvalho, Nadia Cristina Pereira, Matos, Maria de Fatima Cepa, Queiróz, Lyara Meira Marinho, Bogo, Danielle, Zorzatto, José Roberto

“…A series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone…”
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Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione by Ito, Felicia Megumi, Petroni, Jacqueline Marques, de Lima, Dênis Pires, Beatriz, Adilson, Marques, Maria Rita, de Moraes, Manoel Odorico, Costa-Lotufo, Letícia Veras, Montenegro, Raquel Carvalho, Magalhães, Hemerson Iury Ferreira, Pessoa, Cláudia do O

“…Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of…”
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A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage by Oliveira, Rodrigo Juliano, Navarro, Stephanie Dynczuki, de Lima, Dênis Pires, Meza, Alisson, Pesarini, João Renato, da Silva Gomes, Roberto, Karaziack, Caroline Bilhar, de Oliveira Mauro, Mariana, Cunha-Laura, Andréa Luiza, Monreal, Antônio Carlos Duenhas, Romão, Wanderson, Júnior, Valdemar Lacerda, Beatriz, Adilson

“…A large number of studies are attempting to identify alternative products from natural sources or synthesized compounds that effectively interact with cancer…”
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Impact of Iron Mining Activity on the Endophytic Fungal Community of Aspilia grazielae by Weirich, Carlos Eduardo, Marques, Maria Rita, de Castro, Alinne Pereira, Assumpção Benitez, Beatriz, Roque, Fabio de Oliveira, Marchetti, Clarice Rossato, Rodrigues, Amanda Dal'Ongaro, de Lima, Dênis Pires, Dos Santos, Edson Dos Anjos

“…(J. U. Santos) is an endemic plant species in Morro do Urucum in the Pantanal wetland (Brazil). is used for the restoration of areas impacted by iron mining…”
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Flavonoid Derivatives as New Potent Inhibitors of Cysteine Proteases: An Important Step toward the Design of New Compounds for the Treatment of Leishmaniasis by Lourenço, Estela Mariana Guimarães, Di Iório, Juliana Fortes, da Silva, Fernanda, Fialho, Felipe Leonardo Bley, Monteiro, Melquisedeque Mateus, Beatriz, Adilson, Perdomo, Renata Trentin, Barbosa, Euzébio Guimarães, Oses, Jean Pierre, de Arruda, Carla Cardozo Pinto, de Souza Júdice, Wagner Alves, Rafique, Jamal, de Lima, Dênis Pires

“…Leishmaniasis is a neglected tropical disease, affecting more than 350 million people globally. However, there is currently no vaccine available against human…”
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SYNTHESIS AND BIOLOGICAL EVALUATION OF BIARYL ANALOGS OF ANTITUBULIN COMPOUNDS by Tozatti, Camila Santos Suniga, Khodyuk, Rejane Gonçalves Diniz, da Silva, Adriano Olimpio, Dos Santos, Edson Dos Anjos, de Lima, Marcos Serrou do Amaral E Dênis Pires, Hamel, Ernest

“…This paper reports the synthesis of methanones and esters bearing different substitution patterns as spacer groups between aromatic rings. This series of…”
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A Straightforward Method for Synthesizing Bioactive Resorcinolic Lipid Analogues by dos Santos, Denilson Silva, Meza, Alisson, Gomes, Roberto da Silva, de Lima, Denis Pires, Beatriz, Adilson

“…Resorcinolic lipids, a class of bioactive amphiphilic molecules found widely in nature, hold potential for a variety of biological and industrial applications…”
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Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A by Santos, Edson dos Anjos dos, Beatriz, Adilson, Lima, Dênis Pires de, Marques, Maria Rita, Leite, Carla Braga

“…Inspired by the structure and biological activities of resorcinolic lipids and, particularly cytosporone A- a potent inhibitor of plantule germination and…”
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